VivoSeq
Cardiovascular

Abdominal Aortic Aneurysm

25

Pipeline Programs↗

6

Active Trials↗

19

Companies Involved↗

Abdominal Aortic Aneurysm is an emerging landscape with 25 programs across 19 companies. The most active players are Amgen, AstraZeneca, Institut de Recherches Internationales Servier. 11 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

6/100

Mech. Concentration

11/100

Completion Rate

73/100

Attrition Rate

16/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Amgen logo

Amgen

1 program

Phase 1AstraZeneca logo

AstraZeneca

1 program

Phase 2Institut de Recherches Internationales Servier logo

Institut de Recherches Internationales Servier

1 program

Phase 2EMD Serono logo

EMD Serono

1 program

Phase 2A

Amring

1 program

Phase 3Merck & Co. logo

Merck & Co.

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

90%

Small molecule

28 of 31 classified programs — the dominant modality here.

10%ALL OTHERSMonoclonal antibody26%Cell therapy13%

Small molecule leads; the ring shows all 31 classified programs, each share of the total. Modality classified for 100% of 31 pipeline programs.

Analysis

Trial Status

25

clinical trials

Completed11 · 44%
Unknown status4 · 16%
Terminated4 · 16%
Recruiting4 · 16%
Not yet recruiting1 · 4%
Active, not recruiting1 · 4%

Clinical Trials

Trial Activity

25 trials

Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair
Recruiting·UUniversity of Crete·Phase 4·NCT04894864·40 enrolled
Abdominal Aortic Aneurysm Stabilization With Truncal Cells: Controlled Clinical Trial With Historical Cohorts
Recruiting·IInstituto de Investigación Hospital Universitario La Paz·Phase 2·NCT06488898·8 enrolled
Endurant Stent Graft System vs Excluder Endoprothesis: A Global, Prospective, Randomized Clinical Trial in Sac Regression
Recruiting·—·Preclinical·NCT05378347·600 enrolled
A Prospective Multi-centre Observational Real-world Post-market European & Asian Registry With Low-profile Minos™ Abdominal Aortic Stent Graft
Recruiting·SShanghai MicroPort Endovascular MedTech（Group）Co., Ltd·N/A·NCT07674173·200 enrolled
GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis Post-Approval Study
Active, not recruiting·WW.L.Gore & Associates·Preclinical·NCT06578741·310 enrolled
Cardiovascular Rehabilitation After Infrarenal Aortic Aneurysm Repair-REHAB-AAA, a Randomised Controlled Pilot Study
Not yet recruiting·MMedical University Innsbruck·Preclinical·NCT07690046·40 enrolled
Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial)
Completed·YYonsei University·Phase 4·NCT01904981·19 enrolled
Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial
Completed·UUniversity of Maryland, Baltimore·Phase 2·NCT01756833·261 enrolled
Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms
Completed·SSaskatchewan Health Authority - Regina Area·Phase 3·NCT02125890·9 enrolled
Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery
Completed·SSykehuset i Vestfold HF·Phase 4·NCT00538421·193 enrolled
Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair
Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2/3·NCT01225094·606 enrolled
Restrictive Versus Standard Fluid Regime in Elective Minilaparotomy Abdominal Aortic Aneurysm Repair
Completed·UUniversity Clinical Center Tuzla·Phase 1·NCT01939652·60 enrolled
Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms
Completed·PPalo Alto Veterans Institute for Research·Phase 4·NCT01683084·22 enrolled
The Efficacy of Ticagrelor on Abdominal Aortic Aneurysm (AAA) Expansion
Completed·UUppsala University·Phase 2·NCT02070653·145 enrolled
Statin Use in Abdominal Aortic Aneurysm Repair
Completed·UUniversity of Hull·Phase 4·NCT01062802·40 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)