VivoSeq
Gastroenterology

Acute Diarrhea

15

Pipeline Programs↗

1

Active Trials↗

4

Companies Involved↗

Acute Diarrhea is an emerging landscape with 15 programs across 4 companies. The most active players are Johnson & Johnson, Pfizer, Sanofi. 5 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

42/100

Pipeline Velocity

6/100

Mech. Concentration

33/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Johnson & Johnson logo

Johnson & Johnson

2 programs

Phase 3Pfizer logo

Pfizer

1 program

Phase 3Sanofi logo

Sanofi

2 programs

ApprovedS

Salix

1 program

Approved

Pipeline

Programs by Phase

Analysis

Trial Status

17

clinical trials

Completed15 · 88%
Unknown status1 · 6%
Recruiting1 · 6%

Clinical Trials

Trial Activity

17 trials

Rifaximin 200 mg Plus Oral Rehydration vs Oral Rehydration Alone in Children With Acute Diarrhea
Recruiting·BBausch Health Americas, Inc.·Phase 4·NCT07285785·54 enrolled
Use of Probiotic Yogurt in the Treatment of Acute Diarrhea in Children
Completed·CCentro Pediatrico Albina de Patino·Phase 4·NCT01564290·54 enrolled
Oral Administration of Tannins and Flavonoids in Children With Acute Diarrhea
Completed·FFederico II University·Phase 4·NCT03356327·60 enrolled
Controlled Study to Evaluate the Efficacy and Safety of Racecadotril in Infants, Children and Adolescents With Acute Diarrhea
Completed·AAbbott·Phase 3·NCT03463512·124 enrolled
Zinc-ORS in Severe and Complicated Acute Diarrhea
Completed·Centre For International Health·Phase 2/3·NCT00370968·352 enrolled
Study to Evaluate the Efficacy and Safety of Racecadotril in Children Aged 3 to 60 Months Suffering From Acute Diarrhea
Completed·AAbbott·Phase 3·NCT03473561·31 enrolled
Use of Nitazoxanide and Probiotics in Acute Diarrhea Secondary to Rotavirus
Completed·CCentro Pediatrico Albina de Patino·N/A·NCT00683982·75 enrolled
Zinc Plus Saccharomyces Boulardii Versus Zinc Alone in the Treatment of Acute Diarrhea
Completed·—·N/A·NCT07168304·276 enrolled
Safety, Efficacy and Cost-effectiveness of Racecadotril in Children With Acute Diarrhea in Mexico
Completed·National Institute of Pediatrics, Mexico·Phase 3·NCT01153854·454 enrolled
Oral Zinc for the Treatment of Acute Diarrhea in US Children
Completed·—·N/A·NCT01198587·71 enrolled
Evaluation Of Bacillus Clausii In Treatment Of Acute Diarrhea In Latin American Children
Completed·Sanofi logoSanofi·Phase 4·NCT02169817·629 enrolled
Efficacy of Use of Zinc in the Treatment of Acute Diarrhea in Infants
Completed·CCentro Pediatrico Albina de Patino·Phase 4·NCT01571856·52 enrolled
Impact of Home Zinc Treatment for Acute Diarrhea in Children
Completed·Centers for Disease Control and Prevention·Phase 3·NCT00530829·3,000 enrolled
Sulfasalazine in Preventing Acute Diarrhea in Patients With Cancer Who Are Undergoing Pelvic Radiation Therapy
Completed·Alliance for Clinical Trials in Oncology·Phase 3·NCT01198145·87 enrolled
Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and Flatulence
Completed·Johnson & Johnson logoJohnson & Johnson·Phase 3·NCT02340481·217 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)