VivoSeq
Neurology

AIDS Dementia

8

Pipeline Programs↗

0

Active Trials↗

6

Companies Involved↗

AIDS dementia is an early-stage landscape with 8 programs across 6 companies. The most active players are Centaur Pharmaceuticals, Bristol-Myers Squibb, AbbVie. 2 therapies are approved with 3 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

33/100

Pipeline Velocity

0/100

Mech. Concentration

67/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

C

Centaur Pharmaceuticals

1 program

Phase 2Bristol-Myers Squibb logo

Bristol-Myers Squibb

1 program

Phase 2AbbVie logo

AbbVie

1 program

Phase 2K

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

1 program

Phase 3A

Azurity Pharmaceuticals

1 program

ApprovedGSK logo

GSK

2 programs

Approved

Pipeline

Programs by Phase

Analysis

Trial Status

6

clinical trials

Completed5 · 83%
Unknown status1 · 17%

Clinical Trials

Trial Activity

6 trials

A Phase III, Randomized, Double-Blind, Multicentre Study to Evaluate the Safety and Efficacy of 1592U89 in Patients With AIDS Dementia Complex
Completed·GSK logoGSK·Phase 3·NCT00002163
An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts
Completed·National Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000709·50 enrolled
Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex
Completed·National Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000657·80 enrolled
A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)
Completed·National Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000867·120 enrolled
A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex
Completed·Bristol-Myers Squibb logoBristol-Myers Squibb·Phase 3·NCT00002246·20 enrolled
Safety and Effectiveness of Giving CPI-1189 to HIV-Infected Patients With AIDS Dementia
Unknown status·CCentaur Pharmaceuticals·Phase 2·NCT00002414·60 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)