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Psychiatry/Alcohol Use Disorder (AUD)

Alcohol Use Disorder (AUD)

7

Pipeline Programs↗

23

Active Trials↗

9

Companies Involved↗

Alcohol Use Disorder (AUD) is an early-stage landscape with 7 programs across 9 companies.

Intelligence

Pipeline Metrics

Competitive Density

44/100

Pipeline Velocity

39/100

Mech. Concentration

20/100

Completion Rate

100/100

Attrition Rate

0/100

Pipeline

Programs by Phase

Preclinical1

Cannabidiol

Jazz Pharmaceuticals

Phase 1

No programs

Phase 26

Zonisamide

Azurity Pharmaceuticals

Tirzepatide

Eli Lilly

Pregnenolone

VA Office of Research and Development

Oleoylethanolamide

Medical University of South Carolina

Psilocybin

COMPASS Pathways

Phase 3

No programs

Approved

No programs

Analysis

Modality Breakdown

83%

Small molecule

5 of 6 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 6 classified programs, each share of the total. Modality classified for 86% of 7 pipeline programs.

Analysis

Trial Status

31

clinical trials

Recruiting12 · 39%

Completed8 · 26%

Not yet recruiting7 · 23%

Active, not recruiting3 · 10%

Enrolling by invitation1 · 3%

Clinical Trials

Trial Activity

31 trials

Guanfacine for Alcohol Use Disorder (AUD)

Recruiting·IIndiana University·Phase 2·NCT06629259·200 enrolled

Imaging Mitochondrial Complex-I With [F-18]BCPP-EF Positron Emission Tomography (PET) in Alcohol Use Disorder (AUD)

Recruiting·—·Phase 1·NCT07825818·100 enrolled

Exercise Training Decreases Alcohol Consumption and Tissue Injury by an FGF21-dependent Mechanism

Recruiting·TThe Cleveland Clinic·Preclinical·NCT07824089·30 enrolled

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

Recruiting·YYale University·Phase 1·NCT06070649·63 enrolled

Sensory and Physiological Responses to Beverage Stimuli: A Randomized Crossover Study

Recruiting·UUniversity of Texas Southwestern Medical Center·Preclinical·NCT07788716·20 enrolled

Effects of a Body-Focused Mindfulness Intervention Added to Standard Inpatient Alcohol Use Disorder Treatment on Emotion Regulation, Interoceptive Awareness, and Alcohol Craving: A Randomized Controlled Trial

Recruiting·MMedical University of Warsaw·Preclinical·NCT07706660·240 enrolled

Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms

Recruiting·National Institute on Alcohol Abuse and Alcoholism (NIAAA)·Preclinical·NCT06484075·180 enrolled

Remote Treatment With Incentives for Sobriety (TRIS): A Randomized Controlled Trial of a Contingency Management App for Alcohol Use Disorder

Recruiting·UUniversity of Sao Paulo General Hospital·Preclinical·NCT07735585·130 enrolled

Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD), a Phase 1b Study

Recruiting·National Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 1·NCT07559500·176 enrolled

Tirzepatide for the Treatment of Alcohol Use Disorder: A Pilot Randomized Controlled Trial

Recruiting·BBrigham and Women's Hospital·Phase 2·NCT06727331·20 enrolled

Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking

Recruiting·WWashington State University·Phase 2·NCT05181891·205 enrolled

A Double-masked, Randomized, Phase II Study to Compare the Effectiveness of 20mg Oral Suvorexant (SUV) Versus Placebo (1:1) in Participants With Co-occurring Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD)

Recruiting·PPharmacotherapies for Alcohol and Substance Use Disorders Alliance·Phase 2·NCT06679062·76 enrolled

A Focus on Alpha-1 Blockade as a Novel Pharmacological Treatment for AUD

Active, not recruiting·BBrown University·Phase 2·NCT04135846·184 enrolled

PsiloStudy: A Phase 2 Single-site, Double-blind, Placebo-controlled, Randomized Clinical Trial With an Open-label Extension Phase to Examine the Safety, Subjective Experiences, Acute Effects, and Suitability of Psilocybin Combined With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD)

Active, not recruiting·—·Phase 2·NCT06853912·40 enrolled

Zonisamide for the Treatment of Alcohol Use Disorder in the Addiction Neuroclinical Assessment Framework

Active, not recruiting·WWashington State University·Phase 2·NCT05134857·205 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)