VivoSeq
3

Pipeline Programs

24

Active Trials

29

Companies Involved

ALS is an early-stage landscape with 3 programs across 29 companies. The most active players are Roche, Biogen, Novartis. 2 therapies are approved.

Pipeline Metrics

Competitive Density

41/100

Pipeline Velocity

19/100

Mech. Concentration

33/100

Completion Rate

84/100

Attrition Rate

11/100

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Programs by Phase

Preclinical
No programs
Phase 1
No programs
Phase 3
No programs

Modality Breakdown

67%

RNA therapy

2 of 3 classified programs — the dominant modality here.

33%ALL OTHERSSmall molecule133%

RNA therapy leads; the ring shows all 3 classified programs, each share of the total. Modality classified for 100% of 3 pipeline programs.

Trial Status

155

clinical trials

Completed91 · 59%
Unknown status18 · 12%
Terminated15 · 10%
Recruiting12 · 8%
Active, not recruiting8 · 5%
Not yet recruiting4 · 3%
Other7 · 5%

Trial Activity

155 trials

RAPA-501 Therapy for ALS
Recruiting·RRapa Therapeutics LLC·Phase 2/3·NCT04220190·41 enrolled
iGlarLixi CGM Study in Chinese T2D Individuals After OADs
Recruiting·Sanofi logoSanofi·Phase 4·NCT06671587·678 enrolled
Dosing of LT4 in Older Individuals
Recruiting·UUniversity of Pennsylvania·Phase 4·NCT06073665·228 enrolled
Targeted Naltrexone to Support Individuals Participating in Dry January
Recruiting··Phase 2·NCT07132177·20 enrolled
A Study of Ranolazine in ALS
Recruiting··Phase 2·NCT06527222·72 enrolled
ATLAS-2: Tofersen in Pre-Symptomatic SOD1-ALS
Recruiting·Biogen logoBiogen·Phase 3·NCT04856995·150 enrolled
A Study Evaluating the Safety and Tolerability of QRL-201 in ALS
Active, not recruiting·QQurAlis Corporation·Phase 1·NCT05633459·64 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)