VivoSeq
Neurology

Alzheimer Disease, Early Onset

3

Pipeline Programs↗

3

Active Trials↗

2

Companies Involved↗

Alzheimer Disease, Early Onset is an early-stage landscape with 3 programs across 2 companies. The most active players are Denali Therapeutics Inc., Eli Lilly.

Intelligence

Pipeline Metrics

Competitive Density

25/100

Pipeline Velocity

11/100

Mech. Concentration

N/A

Completion Rate

N/A

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

D

Denali Therapeutics Inc.

1 program

Phase 1Eli Lilly logo

Eli Lilly

1 program

Phase 1

Pipeline

Programs by Phase

Preclinical
No programs
Phase 13

DNL628

Denali Therapeutics Inc.

THN391

Therini Bio, Inc.

PMN310

ProMis Neurosciences, Inc

Phase 2
No programs
Phase 3
No programs
Approved
No programs

Analysis

Trial Status

3

clinical trials

Active, not recruiting2 · 67%
Recruiting1 · 33%

Clinical Trials

Trial Activity

A Phase 1b, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of PMN310 in Patients With Early Alzheimer's Disease
Active, not recruiting·PProMis Neurosciences, Inc·Phase 1·NCT06750432·144 enrolled
A Double-blind, Randomized, Placebo-controlled, Phase 1b Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of THN391 in Early Alzheimer's Disease Subjects
Active, not recruiting·TTherini Bio, Inc.·Phase 1·NCT06814730·19 enrolled
A Phase 1b, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's Disease
Recruiting·DDenali Therapeutics Inc.·Phase 1·NCT07328451·68 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)