VivoSeq
Musculoskeletal

Ankle Fracture

14

Pipeline Programs↗

5

Active Trials↗

9

Companies Involved↗

Ankle Fracture is an emerging landscape with 14 programs across 9 companies. The most active players are Almaject, Alnylam Pharmaceuticals, Hikma Pharmaceuticals LLC. 7 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

43/100

Pipeline Velocity

0/100

Mech. Concentration

30/100

Completion Rate

75/100

Attrition Rate

16/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

A

Almaject

1 program

Phase 1Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

1 program

ApprovedH

Hikma Pharmaceuticals LLC

1 program

ApprovedF

Fresenius Kabi Oncology Ltd.

1 program

ApprovedP

Protega

1 program

ApprovedP

Purdue Pharma LP

1 program

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

96%

Small molecule

26 of 27 classified programs — the dominant modality here.

4%ALL OTHERSPeptide14%

Small molecule leads; the ring shows all 27 classified programs, each share of the total. Modality classified for 100% of 27 pipeline programs.

Analysis

Trial Status

19

clinical trials

Completed9 · 47%
Recruiting3 · 16%
Unknown status2 · 11%
Withdrawn2 · 11%
Active, not recruiting1 · 5%
Terminated1 · 5%
Other1 · 5%

Clinical Trials

Trial Activity

19 trials

Randomized Controlled Trial for Ankle Fracture Pain Control
Recruiting·LLahey Clinic·Phase 4·NCT03696199·70 enrolled
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Recruiting·—·Phase 4·NCT06949826·100 enrolled
The Efficacy and Safety of Venostan in Promoting Postoperative Swelling Reduction in Patients With Ankle Fractures
Recruiting·—·N/A·NCT06872034·290 enrolled
Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures
Active, not recruiting·UUniversity of Utah·Phase 1·NCT05019638·200 enrolled
Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT
Not yet recruiting·UUniversity of Calgary·Phase 1/2·NCT06303284·80 enrolled
Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery
Completed·UUniversity College Cork·Phase 4·NCT06864312·120 enrolled
The D-KAF (Dalteparin in Knee-to-Ankle Fracture) Trial
Completed·SSunnybrook Health Sciences Centre·Phase 4·NCT00187408·700 enrolled
Anesthesia for Pain After Ankle Fracture Surgery
Completed·UUniversity of Cincinnati·Phase 4·NCT02950558·14 enrolled
NSAIDS Versus Opioids in Acute SER II Ankle Fractures
Completed·UUniversity of California, Davis·Phase 1·NCT02373254·1 enrolled
Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures
Completed·UUniversity of Iowa·Phase 4·NCT02967172·100 enrolled
Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients
Completed·IInstituto Mexicano del Seguro Social·Phase 3·NCT02949674·93 enrolled
Postoperative Aspirin and Ankle Fracture Healing
Completed·UUniversity of Alabama at Birmingham·Phase 1·NCT03765619·500 enrolled
Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
Completed·JJamaica Hospital Medical Center·Phase 3·NCT02480621·84 enrolled
The Therapeutic Effect of Dau-Di-Wu-Gong in Patient With Ankle Fracture
Completed·—·Phase 1/2·NCT03805347·45 enrolled
Intra Articular Ankle Fractures
Terminated·—·N/A·NCT05465382·41 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)