VivoSeq
Psychiatry

Anorexia

14

Pipeline Programs↗

3

Active Trials↗

12

Companies Involved↗

Anorexia is an emerging landscape with 14 programs across 12 companies. The most active players are Pfizer, Helsinn Therapeutics (U.S.), Inc, Ohr Pharmaceutical Inc.. 2 therapies are approved with 3 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

42/100

Pipeline Velocity

6/100

Mech. Concentration

22/100

Completion Rate

90/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Pfizer logo

Pfizer

1 program

Phase 1H

Helsinn Therapeutics (U.S.), Inc

1 program

Phase 2O

Ohr Pharmaceutical Inc.

1 program

Phase 2COMPASS Pathways logo

COMPASS Pathways

1 program

Phase 2K

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

1 program

Phase 2P

Par Pharmaceutical, Inc.

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

88%

Small molecule

14 of 16 classified programs — the dominant modality here.

13%ALL OTHERSMonoclonal antibody16%Protein / enzyme16%

Small molecule leads; the ring shows all 16 classified programs, each share of the total. Modality classified for 100% of 17 pipeline programs.

Analysis

Trial Status

16

clinical trials

Completed9 · 56%
Unknown status3 · 19%
Recruiting3 · 19%
Terminated1 · 6%

Clinical Trials

Trial Activity

16 trials

Study of Psilocybin for Anorexia in Young Adults
Recruiting·MMarissa Raymond-Flesch, MD, MPH·Phase 2·NCT06399263·40 enrolled
Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial
Recruiting·RRoswell Park Cancer Institute·Phase 2·NCT06995508·66 enrolled
Olanzapine for Cancer Related Anorexia-cachexia Syndrome
Recruiting·MMahidol University·Phase 3·NCT06517199·138 enrolled
Etanercept in Treating Cancer-Related Cachexia and Anorexia in Patients With Advanced Cancer
Completed·MMayo Clinic·Phase 3·NCT00046904
Effect of Sipjeondaebo-tang for Cancer Related Anorexia in Cancer Patients
Completed·KKyunghee University Medical Center·N/A·NCT02468141·32 enrolled
Olanzapine Anorexia Cachexia
Completed·—·Phase 3·NCT05243251·164 enrolled
Comparison Between Mirtazapine and Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.
Completed·UUniversity of Sao Paulo·Phase 2·NCT03283488·52 enrolled
Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia
Completed·Pfizer logoPfizer·Phase 1·NCT04803305·18 enrolled
Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia
Completed·HHelsinn Therapeutics (U.S.), Inc·Phase 2·NCT00378131·51 enrolled
A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexia
Completed·Bristol-Myers Squibb logoBristol-Myers Squibb·Phase 3·NCT00002067
Mirtazapine for Treatment of Cancer Associated Anorexia-cachexia
Completed·—·Phase 2/3·NCT03254173·120 enrolled
Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia.
Completed·HHelsinn Therapeutics (U.S.), Inc·Phase 2·NCT00267358
Treatment of Cancer-associated Anorexia Using Megestrol Acetate Concentrated Suspension
Terminated·PPar Pharmaceutical, Inc.·Phase 3·NCT00637806·4 enrolled
Open Label Study With OHR/AVR118 in Advanced Cancer Patients With Anorexia-Cachexia
Unknown status·OOhr Pharmaceutical Inc.·Phase 2·NCT01206335·20 enrolled
Mirtazapine Versus Megestrol Acetate in Treatment of Anorexia-cachexia in Advanced Cancer Patients.
Unknown status·—·Phase 2·NCT05380479·80 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)