VivoSeq
Cardiovascular

Aortic Valve Stenosis

3

Pipeline Programs↗

10

Active Trials↗

4

Companies Involved↗

Aortic Valve Stenosis is an early-stage landscape with 3 programs across 4 companies. The most active players are Daewoong Pharmaceutical Co. LTD., Sanofi, Eli Lilly. 1 therapy is approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

33/100

Pipeline Velocity

11/100

Mech. Concentration

N/A

Completion Rate

75/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Daewoong Pharmaceutical Co. LTD. logo

Daewoong Pharmaceutical Co. LTD.

1 program

ApprovedSanofi logo

Sanofi

1 program

PreclinicalEli Lilly logo

Eli Lilly

1 program

PreclinicalE

EmStop Inc

0 programs

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

15

clinical trials

Recruiting8 · 53%
Completed3 · 20%
Active, not recruiting2 · 13%
Unknown status1 · 7%
Terminated1 · 7%

Clinical Trials

Trial Activity

15 trials

Effect of PCSK9 Inhibitors on Calcific Aortic Valve Stenosis
Recruiting·—·Phase 3·NCT04968509·160 enrolled
Effect of Colchicine on the Progression of Aortic Valve Stenosis - a Pilot Study
Recruiting·OOttawa Heart Institute Research Corporation·Phase 2/3·NCT05253794·24 enrolled
Spanish Prospective Registry of Hydra THV for Transcatheter Aortic Valve Implantation
Recruiting·FFundación EPIC·N/A·NCT07566624·100 enrolled
A Phase 2b/3, Randomized, Double-Blinded, Placebo Controlled Study ChecKing the Efficacy and Safety of ATAciguat to Slow the Progression of VaLvular DYsfunction in Participants With Moderate Calcific Aortic Valve STenosis
Recruiting·KKardigan, Inc.·Preclinical·NCT07001800·1,276 enrolled
In-vitro Benchmarking of Currently Available Heart Valve Prostheses for Surgical and Percutaneous Treatment of Aortic Stenosis With Small Annulus, Followed by In-vivo Validation
Recruiting·IIRCCS Policlinico S. Donato·Preclinical·NCT06859255·200 enrolled
A Randomized, Double-Blind, Placebo-controlled Trial to Evaluate Efficacy and Safety of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, Enavogliflozin Compared to Placebo on Reducing Major Cardiovascular Events or Worsening Heart Failure in Patients With Severe Aortic Stenosis Who Underwent Transcatheter Aortic Valve Replacement (TAVR) and With Heart Failure With Preserved Ejection Fraction (HFpEF)
Recruiting·DDuk-Woo Park, MD·Approved·NCT05672836·1,040 enrolled
Controlled Arterial Protection to Ultimately Remove Embolic Material
Recruiting·EEmStop Inc·Preclinical·NCT07276711·663 enrolled
Prospective, Multi-centre Clinical Investigation Evaluating the Outcomes of Patients Treated by Redo Transcatheter Aortic Valve Implantation for Bioprosthetic Valve Failure of a Transcatheter Aortic Valve
Recruiting·TThe Leeds Teaching Hospitals NHS Trust·N/A·NCT06557798·550 enrolled
IcoSApent ethyL to Slow Down Aortic VAlve Stenosis proGrEssion
Active, not recruiting·—·Phase 2·NCT06466278·110 enrolled
Effects of Post-Dilatation on THV Expansion, Hemodynamics, Durability, and Outcomes in Balloon-Expandable TAVI Prostheses
Active, not recruiting·MMedical University of Vienna·Preclinical·NCT07477002·146 enrolled
Platelet Function And Aggregometry In Patients With Aortic Valve Stenosis
Completed·UUniversity of Rochester·Phase 4·NCT00156520·40 enrolled
Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis
Completed·—·Phase 1·NCT02049203·44 enrolled
Myocardial Efficiency of the Left Ventricle in Asymptomatic Patients With Aortic Valve Stenosis - a Prognostic Marker and a Target for Intervention?
Completed·—·Phase 2·NCT02076711·40 enrolled
Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI)
Terminated·UUniversity Hospital, Bordeaux·Phase 3·NCT02817789·50 enrolled
Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention
Unknown status·UUniversity of Aarhus·Phase 2/3·NCT05241431·106 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)