VivoSeq
Musculoskeletal

Bone Density

16

Pipeline Programs↗

2

Active Trials↗

10

Companies Involved↗

Bone Density is an emerging landscape with 16 programs across 10 companies. The most active players are Rohto Pharmaceutical Co., Ltd., Vitae Pharmaceuticals Inc., an Allergan affiliate, Pfizer. 1 therapy is approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

43/100

Pipeline Velocity

6/100

Mech. Concentration

22/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

R

Rohto Pharmaceutical Co., Ltd.

1 program

Phase 2V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2Pfizer logo

Pfizer

1 program

Phase 2Amgen logo

Amgen

3 programs

Phase 2AstraZeneca logo

AstraZeneca

1 program

Phase 3Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

2 programs

Preclinical

Pipeline

Programs by Phase

Analysis

Modality Breakdown

89%

Small molecule

16 of 18 classified programs — the dominant modality here.

11%ALL OTHERSMonoclonal antibody16%Cell therapy16%

Small molecule leads; the ring shows all 18 classified programs, each share of the total. Modality classified for 100% of 18 pipeline programs.

Analysis

Trial Status

13

clinical trials

Completed10 · 77%
Not yet recruiting2 · 15%
Unknown status1 · 8%

Clinical Trials

Trial Activity

13 trials

Effectiveness of Topical Application of Melatonin On Bone Density and Implant Stability In Immediate Implantation
Not yet recruiting·UUniversity of Baghdad·Phase 1·NCT07003243·25 enrolled
Romosozumab Effects on Bone Density, Muscle Mass, and Spine Surgery Outcomes
Not yet recruiting·—·Phase 2·NCT06973109·36 enrolled
ATAC - Bone Density Sub-Protocol
Completed·AstraZeneca logoAstraZeneca·Phase 3·NCT00784940·308 enrolled
Risedronate in Postmenopausal Women With Low Bone Density
Completed·Sanofi logoSanofi·Phase 2·NCT00351091·150 enrolled
Effects of Tibilone on Bone Density, Menopause Symptoms and Breast Density in Women After Prophylactic Oophorectomy
Completed·—·Phase 2·NCT00165204·50 enrolled
The Relationship Between Vitamin D, Fingernail Thickness and Bone Density
Completed·NNational Center for Research Resources (NCRR)·Phase 1·NCT00006196
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment
Completed·MMin-Sheng General Hospital·N/A·NCT04637360·40 enrolled
Salivary Bmp-2 Levels & Radiographic Measurement Of Bone Density at Extracted Tooth
Completed·PPostgraduate Medical Institute, Lahore·Phase 4·NCT05369091·24 enrolled
Kaempferol Gel , Alkaline Phosphatase Activity , Bone Density Around Dental Implants
Completed·—·N/A·NCT07156799·30 enrolled
Effects of Vitamin D Supplementation on Strength, Bone Density, and Injury Risk in Collegiate Athletes
Completed·VVirginia Polytechnic Institute and State University·Phase 1·NCT03151174·68 enrolled
Coral Calcium's Effect on Bone Density in Postmenopausal Women With and Without Ibandronate
Completed·—·Phase 2·NCT04321837·60 enrolled
Fractal Analysis of Mandibular Trabecular Bone Changes in Complete Denture Patients Restored With Pre-polymerized Milled PMMA Compared With Light-cured 3D-printed Teeth: a Split-mouth Randomized Clinical Trial
Completed·BBadr University·N/A·NCT06320704·16 enrolled
Evaluation of Clinical and Bone Density Improvement After Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord on Osteoporosis Patients
Unknown status·—·Phase 2·NCT04501354·5 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)