VivoSeq
Other

Bradycardia

9

Pipeline Programs↗

3

Active Trials↗

8

Companies Involved↗

Bradycardia is an early-stage landscape with 9 programs across 8 companies. The most active players are Cardix Therapeutics LLC, Pfizer's Upjohn has merged with Mylan to form Viatris Inc., Fresenius Kabi Oncology Ltd.. 3 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

37/100

Pipeline Velocity

6/100

Mech. Concentration

20/100

Completion Rate

89/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

C

Cardix Therapeutics LLC

1 program

Phase 2P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

Phase 3F

Fresenius Kabi Oncology Ltd.

1 program

ApprovedAmgen logo

Amgen

1 program

PreclinicalM

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

PreclinicalGSK logo

GSK

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

14

clinical trials

Completed8 · 57%
Recruiting3 · 21%
Unknown status2 · 14%
Terminated1 · 7%

Clinical Trials

Trial Activity

14 trials

Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements
Recruiting·UUniversity of Hamburg-Eppendorf·N/A·NCT06922097·186 enrolled
Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up (SEPTA PMCF)
Recruiting·BBoston Scientific Corporation·N/A·NCT07209852·140 enrolled
Prospective Non-Randomized Comparison of Point-by-Point Cryoablation Using Freezor™ Xtra Versus Radiofrequency Ablation Using TactiFlex™ SE of Parasympathetic Ganglia (Cardioneuroablation) in Patients With Vagally-Mediated Bradyarrhythmias
Recruiting·TTomsk National Research Medical Center of the Russian Academy of Sciences·Preclinical·NCT07671898·60 enrolled
Bradycardia Following Intraoperative Administration of Dexmedetomidine
Completed·—·N/A·NCT01917097·921 enrolled
DTaP and Apnea/Bradycardia in Preterm Infants
Completed·AAmerican SIDS Institute·N/A·NCT00482781·191 enrolled
Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Geriatric Patients Undergoing Total Knee Replacement Under Spinal Anesthesia
Completed·YYonsei University·N/A·NCT03322098·54 enrolled
Determination of Remifentanil's ED50 for Rapid Sequence Intubation Avoiding Bradycardia and Hypotension in Adults
Completed·—·Phase 3·NCT03065309·15 enrolled
Atropine or Ephedrine Pretreatment for Preventing Bradycardia in Elderly Patients
Completed·—·Phase 4·NCT03984526·102 enrolled
Effect of Morning vs. Evening Vaccination on Hypoxia and Bradycardia of Preterm Infants: a Randomised Controled Trial
Completed·UUniversity Hospital Tuebingen·Phase 3·NCT02640703·16 enrolled
An Exploratory Safety and Efficacy Clinical Study of CARDIX-101 for the Treatment of Chronic Bradycardia
Completed·CCardix Therapeutics LLC·Phase 1/2·NCT05117346·20 enrolled
Pressure-Volume (PV) Measurements for Evaluating Cardiac Parameters Using BackBeat Medical's Cardiac Neuromodulation Therapy (CNT) Pacing Signals in Different Physiological Pacing Sites: An Acute Study
Completed·BBackBeat Medical Inc·Preclinical·NCT05345925·5 enrolled
Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Terminated·YYonsei University·N/A·NCT03322150·2 enrolled
Shensongyangxin Capsule in the Treatment of Sinus Bradycardia With Premature Ventricular Contractions
Unknown status·—·Phase 4·NCT01750775·330 enrolled
Comparison of Intrathecal Versus Epidural Fentanyl on Fetal Bradycardia in Labor Combined Spinal Epidural Analgesia
Unknown status·—·Phase 4·NCT03623256·558 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)