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Oncology/Cervical Intraepithelial Neoplasia

Cervical Intraepithelial Neoplasia

4

Pipeline Programs↗

13

Active Trials↗

15

Companies Involved↗

Cervical Intraepithelial Neoplasia is an early-stage landscape with 4 programs across 15 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

37/100

Pipeline Velocity

22/100

Mech. Concentration

50/100

Completion Rate

71/100

Attrition Rate

18/100

Pipeline

Programs by Phase

Preclinical1

Pbi-4 Vaccine

Chang Gung Memorial Hospital

Phase 11

Fenofibrate

Jagotec

Phase 21

Pembrolizumab

Merck & Co.

Phase 31

Gardasil-9

Beijing Health Guard Biotechnology, Inc

Approved

No programs

Analysis

Modality Breakdown

2programs

Small molecule150%

Monoclonal antibody150%

Modality classified for 75% of 4 pipeline programs.

Analysis

Trial Status

49

clinical trials

Completed22 · 45%

Not yet recruiting6 · 12%

Recruiting5 · 10%

Terminated5 · 10%

Unknown status5 · 10%

Withdrawn4 · 8%

Other2 · 4%

Clinical Trials

Trial Activity

49 trials

Window of Opportunity Trial of Fenofibrate in Patients With High-grade Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma

Recruiting·LLindsay Ferguson, MD·Phase 1·NCT06191133·24 enrolled

A Randomized, Triple-blind, Placebo-controlled, Parallel Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV

Recruiting·PPapillex Inc.·Preclinical·NCT06979180·60 enrolled

Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia

Recruiting·JJonsson Comprehensive Cancer Center·Phase 2·NCT04712851·25 enrolled

Predicting Response In Cervical Intraepithelial Neoplasia to Topical Imiquimod Treatment

Recruiting·—·N/A·NCT05405270·410 enrolled

Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)

Recruiting·FFrantz Viral Therapeutics, LLC·Phase 2·NCT04098744·78 enrolled

A Randomized, Double-Blind, Placebo-Controlled Phase II Trial of pBI-4 Plasmid Administered Via Intramuscular TriGrid™ Electroporation Delivery System for Treatment of Women With HPV16-Positive Grade 1 Cervical Intraepithelial Neoplasia or Persistent HPV16 Infection

Not yet recruiting·CChang Gung Memorial Hospital·Preclinical·NCT07809997·94 enrolled

Evaluation of Low-thermal Argon Plasma Devitalization (LtAPD) for the Treatment of Cervical Intraepithelial Neoplasia (CIN) Grade 2 Versus Standard of Active Surveillance

Not yet recruiting·UUniversity Hospital Tuebingen·Preclinical·NCT07730645·264 enrolled

Visual Inspection With Acetic Acid of The Cervix Versus Colposcopy in Screening and Detection of Cervical Intraepithelial Neoplasia

Not yet recruiting·SSohag University·N/A·NCT07692919·200 enrolled

A Prospective, Open-label, Randomized, Controlled, Non-inferiority Phase II Study Comparing HAL-PDT With Deferred Surgery Versus Immediate Surgery in Subjects With High-grade Squamous Intraepithelial Lesions (HSIL)

Not yet recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT07669363·230 enrolled

Impact on Disease Relapse of HPV Vaccination in Women Treated With LEEP for Cervical Intraepithelial Neoplasia. HOPE9

Not yet recruiting·—·Phase 3·NCT03848039·1,220 enrolled

A Study in Subjects With Human Papillomavirus 16 or 18 Associated Cervical Intraepithelial Neoplasia Grade 2 or 3

Not yet recruiting·RRinuaGene Biotechnology Co., Ltd.·Phase 1/2·NCT06273553·39 enrolled

Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Enrolling by invitation·National Cancer Institute (NCI)·N/A·NCT04266093·1,000 enrolled

Evaluation of Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias 3 Months After Treatment: a Multicenter, Single-blind, Randomized Controlled Trial

Enrolling by invitation·FFirst Hospital of China Medical University·Preclinical·NCT07059819·400 enrolled

Incidence of Cervical Cancer in HPV-positive Women With Low-grade Cytological Abnormalities

Completed·GGynaecologisch Oncologisch Centrum Zuid·N/A·NCT07259616·46,079 enrolled

Comparison of Cervical Intraepithelial Neoplasia 2/3 Treatment Outcomes With a Portable LMIC-adapted Thermal Ablation Device vs. Gas-based Cryotherapy

Completed·TThe Cleveland Clinic·Preclinical·NCT03429582·1,154 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)