Chronic Periodontitis

48

Pipeline Programs↗

3

Active Trials↗

13

Companies Involved↗

Chronic Periodontitis is a moderately active landscape with 48 programs across 13 companies. The most active players are CD Pharma India Pvt. Ltd., Next Gen Pharma India Pvt. Ltd., EMD Serono. 12 therapies are approved with 12 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

59/100

Pipeline Velocity

0/100

Mech. Concentration

29/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

CD Pharma India Pvt. Ltd.

1 program

Next Gen Pharma India Pvt. Ltd.

1 program

EMD Serono

1 program

AstraZeneca

1 program

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

1 program

Dexcel Pharma Technologies Ltd.

2 programs

Pipeline

Programs by Phase

Preclinical8

Zinc Sulfate

Fakultas Kedokteran Universitas Indonesia

Flagyl

Par Pharmaceutical, Inc.

Chlorhexidine Mouth Rinse

University of Washington

Garcinia Mangostana

Meenakshi Ammal Dental College and Hospital

Receive of Coq10

Islamic Azad University, Sanandaj

Phase 11

Salvadora Persica Root

King Saud University

Phase 215

Azithromycin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Atorvastatin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Metronidazole

DePuy Orthopaedics

Flurbiprofen

Pharmacia and Upjohn

Platelet Rich Fibrin

Government Dental College and Research Institute, Bangalore

Phase 312

Metformin

EMD Serono

Doxycycline

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Rosuvastatin

AstraZeneca

Alendronate

Organon and Co

Indocyanine Green

CHX Technologies Inc.

Approved12

Alendronate Sodium

Mylan Pharmaceuticals Inc

Simvastatin

Organon and Co

Metformin Hydrochloride

Boehringer Ingelheim

Moxifloxacin

Bayer

Montelukast

Organon and Co

Analysis

Trial Status

77

clinical trials

Completed64 · 83%

Unknown status10 · 13%

Active, not recruiting1 · 1%

Recruiting1 · 1%

Enrolling by invitation1 · 1%

Clinical Trials

Trial Activity

77 trials

Human Dental Pulp Mesenchymal Stem Cells for the Treatment of Chronic Periodontitis Patients

Recruiting·PPeking University Third Hospital·Phase 2·NCT05924373·204 enrolled

Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis

Active, not recruiting·—·Phase 4·NCT06856369·120 enrolled

Non-surgical Treatment of Chronic Periodontitis With an Adjunctive Vitamin E and Coenzyme Q10 Supplementation

Enrolling by invitation·IIslamic Azad University, Sanandaj·N/A·NCT06373848·120 enrolled

Melatonin as an Adjunctive Therapy for Chronic Periodontitis.

Completed·MMansoura University·Phase 4·NCT03368430·74 enrolled

Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2/3·NCT02516111·120 enrolled

Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2/3·NCT03204071·90 enrolled

Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis

Completed·FFacultad Nacional de Salud Publica·Phase 4·NCT00805558·76 enrolled

1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2·NCT02168543·46 enrolled

The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis

Completed·TTanta University·Phase 1·NCT04697199·12 enrolled

Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase

Completed·UUniversity of Medicine and Pharmacy at Ho Chi Minh City·Phase 4·NCT04675385·28 enrolled

Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients.

Completed·—·Phase 4·NCT06041178·60 enrolled

Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers

Completed·NNext Gen Pharma India Pvt. Ltd.·Phase 3·NCT02329353·60 enrolled

Comparison of Rosuvastatin With Atorvastatin in Chronic Periodontitis

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2/3·NCT02600520·45 enrolled

Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis

Completed·—·Phase 4·NCT03419429·40 enrolled

Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects

Completed·TTatyasaheb Kore Dental College·Phase 4·NCT02886676·70 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)