Chronic Total Occlusion

Pipeline Programs↗

Active Trials↗

Companies Involved↗

Chronic Total Occlusion is an early-stage landscape with 0 programs across 0 companies.

Intelligence

Pipeline Metrics

Competitive Density

10/100

Pipeline Velocity

0/100

Mech. Concentration

N/A

Completion Rate

50/100

Attrition Rate

33/100

Pipeline

Programs by Phase

No pipeline programs currently tracked for this disease.

Analysis

Trial Status

clinical trials

Completed4 · 33%

Withdrawn2 · 17%

Terminated2 · 17%

Unknown status2 · 17%

Recruiting2 · 17%

Clinical Trials

Trial Activity

12 trials

REvascularization Versus Optimal Medical Therapy on Left Ventricular ISchemia Reduction: Exploring the Associations Between Ischemia, Functional Outcome and Collaterals in the Treatment of Chronic Total Occlusion Patients

Recruiting·AAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)·Preclinical·NCT03756870·48 enrolled

Evaluation of Effectiveness and Safety of Antegrade and Retrograde Approach of Percutaneous Coronary Intervention for Chronic Total Occlusions; Systemic Chronic Total Occlusion Revascularization Korea Research-Chronic Total Occlusion (STRIKE-CTO) Study

Recruiting·SSeung-Whan Lee, M.D., Ph.D.·N/A·NCT03667196·4,000 enrolled

TIcaGrEloR and ABSORB Bioresorbable Vascular Scaffold Implantation for Recovery of Vascular Function After Successful Chronic Total Occlusion Recanalization

Completed·HHospital Clinic of Barcelona·Phase 4·NCT02211066·59 enrolled

Randomized Comparison of Optimal Medical Therapy and Percutaneous Recanalization for Chronic Total Occlusion (COMET-CTO)

Completed·CClinical Centre of Serbia·Phase 4·NCT02964975·100 enrolled

The Effect of Nicorandil on Left Ventricular Myocardial Strain in Patients With Coronary Chronic Total Occlusion

Completed·PPeking University Third Hospital·Phase 4·NCT05087797·61 enrolled

Impact of PREVENTIVE Substrate Ablation of Coronary Chronic Total Occlusion on Implantable cardioVerTer-Defibrillator Interventions

Completed·UUniversity Medical Centre Ljubljana·N/A·NCT03421834·60 enrolled

Drug-Eluting Stent Implantation Versus Optimal Medical Treatment in Patients With Chronic Total Occlusion (DECISION-CTO)

Terminated·—·Phase 4·NCT01078051·840 enrolled

Chronic Total Occlusion Registry

Terminated·—·N/A·NCT04041921·4,006 enrolled

Efficacy of Ranolazine in Patients With Chronic Total Occlusions of Coronary Arteries

Withdrawn·—·Phase 4·NCT02423265

Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO)

Withdrawn·BBoston Scientific Corporation·N/A·NCT04059536

Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions

Unknown status·—·N/A·NCT04744571·200 enrolled

Effect of Evolocumab on Chronic Total Occlusions (EVOLO-CTO)

Unknown status·—·Phase 4·NCT05623995·200 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)