VivoSeq
Ophthalmology

Corneal Ulcer

11

Pipeline Programs↗

1

Active Trials↗

5

Companies Involved↗

Corneal Ulcer is an emerging landscape with 11 programs across 5 companies. The most active players are AbbVie, Prism Pharmaceuticals, Eli Lilly. 2 therapies are approved with 3 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

38/100

Pipeline Velocity

0/100

Mech. Concentration

50/100

Completion Rate

82/100

Attrition Rate

17/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

AbbVie logo

AbbVie

2 programs

Phase 2P

Prism Pharmaceuticals

1 program

Phase 2Eli Lilly logo

Eli Lilly

1 program

ApprovedM

Melinta Therapeutics, Inc.

1 program

ApprovedE

Ensysce Biosciences

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

12

clinical trials

Completed9 · 75%
Terminated2 · 17%
Not yet recruiting1 · 8%

Clinical Trials

Trial Activity

12 trials

Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcers
Not yet recruiting·—·Phase 4·NCT06331910·14 enrolled
Role of Amniotic Membrane Extract Eye Drops as an Adjunctive Therapy in Resistant Corneal Ulcers
Completed·TTanta University·N/A·NCT06909149·40 enrolled
Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers
Completed·AbbVie logoAbbVie·Phase 2·NCT00651586·129 enrolled
Cross-linking for Corneal Ulcers Treatment Trial
Completed·UUniversity of California, San Francisco·Phase 3·NCT02570321·147 enrolled
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
Completed·UUniversity of California, San Francisco·Phase 3·NCT02731638·70 enrolled
Platelet Rich Plasma as a Treatment For Resistant Corneal Ulcers
Completed·—·Phase 4·NCT05515731·14 enrolled
The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal Ulcer
Completed·MMinia University·N/A·NCT05924893·50 enrolled
Steroids for Corneal Ulcers Trial
Completed·—·Phase 4·NCT00324168·500 enrolled
Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer
Completed·UUniversity of California, San Francisco·Phase 1/2·NCT00557362·120 enrolled
A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
Completed·LLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center·Phase 2·NCT00386958·172 enrolled
A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers.
Terminated·CCornea Consultants Of Nashville·Phase 2·NCT01928693·2 enrolled
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine
Terminated·UUniversity of California, Los Angeles·Phase 3·NCT00516399·78 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)