VivoSeq
Other

Endophthalmitis

7

Pipeline Programs↗

2

Active Trials↗

2

Companies Involved↗

Endophthalmitis is an early-stage landscape with 7 programs across 2 companies. The most active players are Bayer, Milestone Pharmaceuticals Inc.. 2 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

33/100

Pipeline Velocity

6/100

Mech. Concentration

50/100

Completion Rate

88/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Bayer logo

Bayer

2 programs

ApprovedM

Milestone Pharmaceuticals Inc.

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

14

clinical trials

Completed7 · 50%
Unknown status4 · 29%
Not yet recruiting2 · 14%
Terminated1 · 7%

Clinical Trials

Trial Activity

14 trials

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery
Not yet recruiting·—·Phase 2/3·NCT03244072·60,000 enrolled
Evaluation and Risk Factors of Post-traumatic Endophthalmitis
Not yet recruiting·—·N/A·NCT06673784·41 enrolled
Endophthalmitis Vitrectomy Study (EVS)
Completed·National Eye Institute (NEI)·Phase 3·NCT00000130
Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis
Completed·UUniversidade Federal de Pernambuco·Phase 2·NCT02595359·1,000 enrolled
Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery
Completed·—·N/A·NCT00136344·35,000 enrolled
Evaluation of Macular Changes After Intracameral Moxifloxacin for Prevention of Endophthalmitis
Completed·UUniversidade Federal de Pernambuco·Phase 4·NCT03363295·120 enrolled
To Compare the Safety and Efficacy of Intracameral Levofloxacin and Intracameral Cefazolin in Reducing Rates of Endophthalmitis Following Cataract Surgery.
Completed·TTan Tock Seng Hospital·Phase 1·NCT06710977·50 enrolled
Prophylaxis of Acute Post-Traumatic Bacterial Endophthalmitis
Completed·SShahid Beheshti University of Medical Sciences·Phase 4·NCT00398658
Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis
Completed·FFederal University of São Paulo·N/A·NCT04192994·25 enrolled
Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis.
Terminated·UUniversity of Campinas, Brazil·Phase 3·NCT02770729·3,640 enrolled
Safety and Efficacy of Topical Moxifloxacin for Prevention of Post-Traumatic Endophthalmitis: Randomized Controlled Clinical Trial
Unknown status·UUniversity of Campinas, Brazil·Phase 2·NCT05162625·100 enrolled
Targeted PCR and Acute Endophthalmitis
Unknown status·UUniversity Hospital, Grenoble·N/A·NCT02850653·150 enrolled
Use Of Intracameral Moxifloxacin For Prophylaxis Of Open Globe Endophthalmitis
Unknown status·FFederal University of São Paulo·Phase 4·NCT05079854·100 enrolled
Endophthalmitis After Intravitreous Anti-VEGF Injections in Patients Receiving vs. Not Receiving Topical Antibiotics
Unknown status·—·N/A·NCT02810587·5,000 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)