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Cardiovascular/Hypertensive

Hypertensive

9

Pipeline Programs↗

18

Active Trials↗

18

Companies Involved↗

Hypertensive is an early-stage landscape with 9 programs across 18 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

44/100

Pipeline Velocity

30/100

Mech. Concentration

N/A

Completion Rate

87/100

Attrition Rate

10/100

Pipeline

Programs by Phase

Preclinical8

Hydrochlorothiazide (HCTZ) or Olmesartan

The Louis & Rachel Rudin Foundation

Antihypertensive Medication

University of Alberta

Standard Medical Therapy

Post Graduate Institute of Medical Education and Research, Chandigarh

Beta Blocker

Weill Medical College of Cornell University

Calcium Channel Blocker

Minia University

Phase 1

No programs

Phase 2

No programs

Phase 31

Hemodynamics-Based Individualized Antihypertensive Therapy

The Third Xiangya Hospital of Central South University

Approved

No programs

Analysis

Trial Status

181

clinical trials

Completed119 · 66%

Unknown status26 · 14%

Terminated10 · 6%

Recruiting9 · 5%

Withdrawn8 · 4%

Not yet recruiting7 · 4%

Other2 · 1%

Clinical Trials

Trial Activity

181 trials

Comparative Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

Recruiting·OOhio State University·Approved·NCT06468202·10,742 enrolled

AtorvaStatin Postpartum and Reduction of Cardiovascular risK (SPARK): A Randomized Placebo-controlled Trial of Atorvastatin Postpartum for Reduction of Cardiovascular Risk

Recruiting·OOhio State University·Approved·NCT06632379·76 enrolled

MH-Rx Study: Comprehensive and Multi-Level Medication Therapy Management and Non-Medical Health Related Needs Targeted Intervention Model for Maternal Health Outcomes. (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure)

Recruiting·Texas Southern University·Preclinical·NCT07842341·158 enrolled

Effectiveness, Safety, and Cost-effectiveness of Salt Substitution in High-risk Pregnant Women for the Prevention of Hypertensive Disorders of Pregnancy

Recruiting·PPeking University·Preclinical·NCT07294807·3,200 enrolled

Cardiometabolic Risk in Pregnancy and Postpartum

Recruiting·—·Preclinical·NCT07420465·200 enrolled

Morning Versus Bedtime Dosing of Antihypertensive Medication

Recruiting·—·Phase 4·NCT05089448·300 enrolled

Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk

Recruiting·—·N/A·NCT07099677·186 enrolled

Eculizumab in Hypertensive Emergency-associated Hemolytic Uremic Syndrome

Recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT05726916·66 enrolled

Effect of Sacubitril/Valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: A Real World Study

Recruiting·—·N/A·NCT05498675·180 enrolled

HEART at Home: Improving Postpartum Cardiovascular Outcomes Through Implementation of a Hybrid Home-Based and Remote Blood Pressure Management Model for Hypertensive Disorders of Pregnancy

Active, not recruiting·WWashington University School of Medicine·N/A·NCT07833904·10 enrolled

Use of a Cloud-connected Remote Blood Pressure Monitoring Program During the Postpartum Period for Hypertensive Women

Active, not recruiting·UUniversity of South Carolina·N/A·NCT06096701·421 enrolled

Postpartum Remote Monitoring and Integration of Mobile Health With Engagement From Community Health Workers for Regulating Elevated Blood Pressure

Not yet recruiting·UUniversity of Nebraska·Preclinical·NCT07606027·404 enrolled

Ophthalmic Artery Doppler in the Puerperium and Maternal Outcomes After Hypertensive Disorders of Pregnancy: a Prospective Cohort Study

Not yet recruiting·UUniversity of Roma La Sapienza·N/A·NCT07841795·366 enrolled

The Effect of Roy Adaptation Model-Based Prenatal Education on Perceived Stress and Quality of Life in Hypertensive Pregnant Women

Not yet recruiting·IIstanbul University - Cerrahpasa·Preclinical·NCT07820306·54 enrolled

Standardized Antihypertensive Treatment Protocol

Not yet recruiting·SShanghai Jiao Tong University School of Medicine·N/A·NCT06790927·400 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)