VivoSeq
Other

Infantile Spasms

19

Pipeline Programs↗

1

Active Trials↗

17

Companies Involved↗

Infantile Spasms is an emerging landscape with 19 programs across 17 companies. The most active players are Roche, UCB, Immedica Pharma AB. 8 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

45/100

Pipeline Velocity

0/100

Mech. Concentration

29/100

Completion Rate

53/100

Attrition Rate

35/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Roche logo

Roche

1 program

Phase 1UCB logo

UCB

1 program

Phase 2I

Immedica Pharma AB

1 program

Phase 2K

Kenvue Brands

1 program

Phase 2AbbVie logo

AbbVie

1 program

Phase 2Novartis logo

Novartis

1 program

Phase 2

Pipeline

Programs by Phase

Analysis

Trial Status

20

clinical trials

Completed9 · 45%
Terminated4 · 20%
Withdrawn3 · 15%
Unknown status2 · 10%
Recruiting1 · 5%
Suspended1 · 5%

Clinical Trials

Trial Activity

20 trials

A Study to Prevent Infantile Spasms Relapse
Recruiting·UUniversity of California, Los Angeles·Phase 2·NCT06819670·40 enrolled
Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms (GWPCARE7)
Completed·Jazz Pharmaceuticals logoJazz Pharmaceuticals·Phase 3·NCT02953548·9 enrolled
Phase 3 Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms: Open-label Extension Phase (GWPCARE7)
Completed·Jazz Pharmaceuticals logoJazz Pharmaceuticals·Phase 3·NCT02954887·9 enrolled
Acceptability Study of a New Paediatric Form of Vigabatrin in Infants and Children With Infantile Spasms or Pharmacoresistant Partial Epilepsy
Completed·OOrphelia Pharma·N/A·NCT02220114·38 enrolled
A Randomized, Controlled Trial of Ganaxolone in Patients With Infantile Spasms
Completed·MMarinus Pharmaceuticals·Phase 2·NCT00441896·57 enrolled
Prednisolone in Infantile Spasms- High Dose Versus Usual Dose
Completed·LLady Hardinge Medical College·Phase 3·NCT01575639·63 enrolled
Evaluation of Neuroinflammation in Children With Infantile Spasms
Completed·WWayne State University·Phase 4·NCT02092883·8 enrolled
Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment
Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00004758·30 enrolled
Addition of Pyridoxine to Prednisolone in Infantile Spasms
Completed·LLady Hardinge Medical College·Phase 3·NCT01828437·62 enrolled
Tricaprilin Infantile Spasms Pilot Study
Completed·CCerecin·Phase 1·NCT04727970·8 enrolled
A Novel Approach to Infantile Spasms
Suspended·UUniversity of Colorado, Denver·Phase 3·NCT03347526·394 enrolled
A Phase 2 Study of Radiprodil in Subjects With Drug-resistant Infantile Spasms (IS)
Terminated·UCB logoUCB·Phase 2·NCT02829827·3 enrolled
A Study to Assess Cannabidiol Oral Solution With Vigabatrin as Initial Therapy in Participants With Infantile Spasms
Terminated·RRadius Pharmaceuticals, Inc.·Phase 3·NCT03421496·2 enrolled
A Study of Orally Administered JBPOS0101 in Refractory Infantile Spasms Patients
Terminated·BBio-Pharm Solutions Co., Ltd.·Phase 2·NCT03976076·16 enrolled
Cannabidiol Oral Solution for Treatment of Refractory Infantile Spasms
Terminated·IINSYS Therapeutics Inc·Phase 2·NCT02551731·9 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)