VivoSeq
Oncology

Intraepithelial Neoplasia

11

Pipeline Programs↗

5

Active Trials↗

5

Companies Involved↗

Intraepithelial Neoplasia is an emerging landscape with 11 programs across 5 companies. The most active players are Pfizer, AstraZeneca, Kyowa Kirin Co., Ltd.. 4 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

40/100

Pipeline Velocity

6/100

Mech. Concentration

17/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Pfizer logo

Pfizer

1 program

Phase 2AstraZeneca logo

AstraZeneca

1 program

Phase 3Kyowa Kirin Co., Ltd. logo

Kyowa Kirin Co., Ltd.

1 program

Phase 3G

Gynecologic Oncology Group

1 program

ApprovedMerck & Co. logo

Merck & Co.

3 programs

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

93%

Small molecule

13 of 14 classified programs — the dominant modality here.

7%ALL OTHERSMonoclonal antibody17%

Small molecule leads; the ring shows all 14 classified programs, each share of the total. Modality classified for 100% of 15 pipeline programs.

Analysis

Trial Status

15

clinical trials

Completed10 · 67%
Recruiting4 · 27%
Active, not recruiting1 · 7%

Clinical Trials

Trial Activity

15 trials

A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia
Recruiting·UUniversity of Florida·Phase 2·NCT07107334·20 enrolled
NWRD09 for HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer
Recruiting·NNewish Technology (Beijing) Co., Ltd.·N/A·NCT07092007·18 enrolled
NWRD09 for HPV-16 Positive and HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer Patients.
Recruiting·NNewish Technology (Beijing) Co., Ltd.·N/A·NCT06741150·18 enrolled
Fuzheng Nizeng Formula for Chronic Atrophic Gastritis With Low-grade Intraepithelial Neoplasia, a Multicenter Randomized Controlled Trial
Recruiting·PPeking University First Hospital·N/A·NCT06324825·144 enrolled
Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia - Long Term Follow-up
Active, not recruiting·—·Phase 3·NCT01357772·500 enrolled
A Pilot Study of Lycopene Supplementation in Prostatic Intraepithelial Neoplasia
Completed·UUniversity of Pittsburgh·Phase 1·NCT00178113·80 enrolled
Exemestane in Treating Patients With Complex Atypical Hyperplasia of the Endometrium/Endometrial Intraepithelial Neoplasia or Low Grade Endometrial Cancer
Completed·National Cancer Institute (NCI)·Phase 2·NCT03300557·40 enrolled
Intra-Anally Administered Artesunate in Patients With High-Grade Anal Intraepithelial Neoplasia (AIN 2/3)
Completed·JJohns Hopkins University·Phase 1·NCT03100045·18 enrolled
Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)
Completed·GGTx·Phase 3·NCT00106691·1,589 enrolled
Topical Interferon Alfa 2b and Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia
Completed·CCoordinación de Investigación en Salud, Mexico·Phase 4·NCT02199327·18 enrolled
Study of Polyphenon E in Men With High-grade Prostatic Intraepithelial Neoplasia
Completed·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT00596011·97 enrolled
HPV (Human Papilloma Virus) Vaccination After Treatment of Anal Intraepithelial Neoplasia (AIN)
Completed·—·Phase 4·NCT02087384·126 enrolled
Clinical Trial for Evaluating the Efficacy and Safety of Electrocoagulation vs Topic Sinecatechins vs Topic Cidofovir Within the Treatment to High-grade Anal Intraepithelial Neoplasia in HIV Homosexual Males
Completed·HHospital Universitari Vall d'Hebron Research Institute·Phase 3·NCT04055142·108 enrolled
A Prospective, With One Site, Open-label Not Controled Trial, for the Observation of Treatment With CIDOFOVIR 1%, 3 Nights Per Week, During 4 Weeks, of Anal Intraepithelial Neoplasia, High Level, in HIV+ Patients
Completed·FFundacion SEIMC-GESIDA·N/A·NCT01946009·20 enrolled
Pembrolizumab in Treating Patients With High Risk Oral Intraepithelial Neoplasia
Completed·MM.D. Anderson Cancer Center·Phase 2·NCT02882282·15 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)