VivoSeq
Other

Irritability

19

Pipeline Programs↗

5

Active Trials↗

14

Companies Involved↗

Irritability is an emerging landscape with 19 programs across 14 companies. The most active players are Viatris Specialty LLC, Boehringer Ingelheim, Daewoong Pharmaceutical Co. LTD.. 8 therapies are approved with 4 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

47/100

Pipeline Velocity

11/100

Mech. Concentration

8/100

Completion Rate

75/100

Attrition Rate

17/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

V

Viatris Specialty LLC

1 program

Phase 2Boehringer Ingelheim logo

Boehringer Ingelheim

1 program

Phase 2Daewoong Pharmaceutical Co. LTD. logo

Daewoong Pharmaceutical Co. LTD.

1 program

Phase 2Novo Nordisk logo

Novo Nordisk

1 program

Phase 2A

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

1 program

Phase 2Bristol-Myers Squibb logo

Bristol-Myers Squibb

2 programs

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

96%

Small molecule

22 of 23 classified programs — the dominant modality here.

4%ALL OTHERSProtein / enzyme14%

Small molecule leads; the ring shows all 23 classified programs, each share of the total. Modality classified for 100% of 23 pipeline programs.

Analysis

Trial Status

18

clinical trials

Completed9 · 50%
Recruiting3 · 17%
Terminated3 · 17%
Unknown status1 · 6%
Not yet recruiting1 · 6%
Active, not recruiting1 · 6%

Clinical Trials

Trial Activity

18 trials

Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants
Recruiting·MMilton S. Hershey Medical Center·Phase 4·NCT06871488·136 enrolled
RESist Against Irritability Superiority Trial
Recruiting·UUniversity Hospital, Montpellier·N/A·NCT05528926·270 enrolled
Psychological Treatments for Youth With Severe Irritability
Recruiting·National Institute of Mental Health (NIMH)·N/A·NCT02531893·200 enrolled
Targeting Fronto-Striatal Neural Circuitry Using Repetitive Transcranial Magnetic Stimulation to Reduce Irritability
Active, not recruiting·YYale University·Preclinical·NCT07678060·20 enrolled
Psychotherapy for Irritability in Youth: Comparing Active Treatment to Non-Active Psychoeducation Supportive Psychotherapy
Not yet recruiting·National Institute of Mental Health (NIMH)·N/A·NCT07640802·300 enrolled
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
Completed·UUniversity of Texas Southwestern Medical Center·Phase 2·NCT05046184·165 enrolled
Phase IV Long-term Maintenance Study of Aripiprazole in the Treatment of Irritability Associated With Autistic Disorder
Completed·Bristol-Myers Squibb logoBristol-Myers Squibb·Phase 4·NCT01227668·215 enrolled
Assessing Neuropsychiatric Symptoms Including Depression, Anxiety, Irritability, and Suicidal Thoughts or Behavior in Subjects Quitting Smoking on Varenicline Tartrate or Placebo
Completed·Pfizer logoPfizer·Phase 4·NCT00749944·110 enrolled
Irritability in Children With ADHD and Emotion Dysregulation
Completed·TTri-Service General Hospital·Phase 4·NCT05974241·36 enrolled
Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability
Completed·WWake Forest University Health Sciences·N/A·NCT00627250·76 enrolled
Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease
Completed·TThe University of Texas Health Science Center, Houston·Phase 3·NCT03854019·20 enrolled
Estrogen Variability and Irritability During the Menopause Transition
Completed·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT05388656·40 enrolled
Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT04051320·23 enrolled
A Study to Evaluate the Efficacy and Safety of Risperidone (R064766) in Children and Adolescents With Irritability Associated With Autistic Disorder
Completed·Johnson & Johnson logoJohnson & Johnson·Phase 3·NCT01624675·39 enrolled
Neurophysiological Markers of Pediatric Irritability and Its Response to Intervention
Terminated·MMilton S. Hershey Medical Center·Phase 4·NCT03279952·11 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)