VivoSeq
Neurology

Lower Limb Spasticity

6

Pipeline Programs↗

0

Active Trials↗

6

Companies Involved↗

Lower limb spasticity is an early-stage landscape with 6 programs across 6 companies. The most active players are GSK, Supernus Pharmaceuticals, Inc., Merz Pharmaceuticals GmbH. 1 therapy is approved with 3 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

29/100

Pipeline Velocity

0/100

Mech. Concentration

100/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

GSK logo

GSK

1 program

Phase 3Supernus Pharmaceuticals, Inc. logo

Supernus Pharmaceuticals, Inc.

1 program

Phase 3M

Merz Pharmaceuticals GmbH

1 program

Phase 3R

Revance Therapeutics, Inc.

1 program

PreclinicalIpsen logo

Ipsen

0 programs

PreclinicalAbbVie logo

AbbVie

0 programs

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

13

clinical trials

Completed11 · 85%
Unknown status2 · 15%

Clinical Trials

Trial Activity

13 trials

Dysport® Adult Lower Limb Spasticity Follow-on Study
Completed·Ipsen logoIpsen·Phase 3·NCT01251367·352 enrolled
BOTOX® Treatment in Pediatric Lower Limb Spasticity
Completed·AbbVie logoAbbVie·Phase 3·NCT01603628·384 enrolled
Dysport® Adult Lower Limb Spasticity Study
Completed·Ipsen logoIpsen·Phase 3·NCT01249404·388 enrolled
BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity
Completed·AbbVie logoAbbVie·Phase 3·NCT01575054·468 enrolled
Dysport® Pediatric Lower Limb Spasticity Study
Completed·Ipsen logoIpsen·Phase 3·NCT01249417·241 enrolled
Effectiveness and Safety of Dysport® (abobotulinumtoxinA) in Paediatric Lower Limb Spasticity
Completed·Ipsen logoIpsen·N/A·NCT03017729·242 enrolled
BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity
Completed·AbbVie logoAbbVie·Phase 3·NCT01603641·370 enrolled
RELIEF Study: Lower Limb Pain Relief After Injection Cycles in Adults Suffering From Lower Limb Spasticity Following Stroke
Completed·Ipsen logoIpsen·N/A·NCT02020980·186 enrolled
Dysport® Pediatric Lower Limb Spasticity Follow-on Study
Completed·Ipsen logoIpsen·Phase 3·NCT01251380·216 enrolled
Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity
Completed·GSK logoGSK·Phase 3·NCT00460655·120 enrolled
Safety of Xeomin for Lower Limb Spasticity in Multiple Sclerosis Patients
Completed·MMultiple Sclerosis Center of Northeastern New York·Phase 4·NCT01968902·27 enrolled
INcobotulinumtoxina in ChIldren Upper and Lower Limb sPasticITy (INCIPIT)
Unknown status·UUniversita di Verona·Phase 2·NCT05340439·30 enrolled
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity
Unknown status·Supernus Pharmaceuticals, Inc. logoSupernus Pharmaceuticals, Inc.·Phase 2/3·NCT04099667·272 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)