VivoSeq
Gastroenterology

Lumbar Disc Herniation

7

Pipeline Programs↗

4

Active Trials↗

3

Companies Involved↗

Lumbar Disc Herniation is an early-stage landscape with 7 programs across 3 companies. The most active players are Sanofi, Stayble Therapeutics, Intrinsic Therapeutics. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

34/100

Pipeline Velocity

15/100

Mech. Concentration

100/100

Completion Rate

92/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Sanofi logo

Sanofi

1 program

Phase 1S

Stayble Therapeutics

0 programs

PreclinicalI

Intrinsic Therapeutics

0 programs

Preclinical

Pipeline

Programs by Phase

Analysis

Modality Breakdown

88%

Small molecule

7 of 8 classified programs — the dominant modality here.

13%ALL OTHERSProtein / enzyme113%

Small molecule leads; the ring shows all 8 classified programs, each share of the total. Modality classified for 82% of 11 pipeline programs.

Analysis

Trial Status

17

clinical trials

Completed12 · 71%
Recruiting2 · 12%
Not yet recruiting2 · 12%
Withdrawn1 · 6%

Clinical Trials

Trial Activity

17 trials

Immune Response During the Conservative and Minimal Invasive Treatment of Pain Caused by Lumbar Disc Herniation
Recruiting·JJosip Juraj Strossmayer University of Osijek·N/A·NCT06545812·128 enrolled
Comparison of the Effectiveness of High-Intensity Laser Therapy and Transforaminal Epidural Steroid Injection in Patients With Chronic Axial and Radicular Low Back Pain Due to Lumbar Disc Herniation: A Prospective Randomized Controlled Trial
Recruiting·AAnkara City Hospital Bilkent·Preclinical·NCT07688915·24 enrolled
Return to Activity After Surgery for Lumbar Disc Herniation: An Exploratory, Post-Market, Prospective, Randomized, Controlled Trial of an Annular Closure Device
Not yet recruiting·IIntrinsic Therapeutics·Approved·NCT07667348·120 enrolled
Effect of Intraoperative Magnesium Infusion on Postoperative Emergence Agitation in Patients Undergoing Lumbar Microdiscectomy
Not yet recruiting·OOndokuz Mayıs University·N/A·NCT07139847·70 enrolled
"Platelet-Rich Plasma" Epidural Injection an Emerging Strategy in Lumbar Disc Herniation
Completed·QQueen Savang Vadhana Memorial Hospital, Thailand·N/A·NCT05234840·30 enrolled
A Study of SI-6603 in Patients With Lumbar Disc Herniation
Completed·SSeikagaku Corporation·Phase 3·NCT02421601·1,011 enrolled
A Study of SI-6603 in Patients With Lumbar Disc Herniation
Completed·SSeikagaku Corporation·Phase 3·NCT01941563·385 enrolled
STA363 in the Treatment of Lumbar Disc Herniation
Completed·SStayble Therapeutics·Phase 1·NCT06022263·25 enrolled
Clinical Trial to Assess Safety of SI-6603 in Patients With Lumbar Disc Herniation
Completed·SSeikagaku Corporation·Phase 2·NCT01282606·18 enrolled
SI-6603 Versus Placebo in Patients With Lumbar Disc Herniation
Completed·SSeikagaku Corporation·Phase 2/3·NCT00634946·195 enrolled
Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation
Completed·JJaseng Medical Foundation·N/A·NCT02384928·60 enrolled
Strengthening Exercise and Activities of Daily Living Instructions for Patients With Lumbar Disc Herniation
Completed·—·N/A·NCT05021718·70 enrolled
SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)
Completed·SSeikagaku Corporation·Phase 3·NCT03607838·352 enrolled
A Study to Evaluate Safety and Exploratory Efficacy of KTP-001 in Subjects With Lumbar Disc Herniation
Completed·TTeijin America, Inc.·Phase 1/2·NCT01978912·24 enrolled
The Effect of Mindfulness-based Psychoeducation on Mindfulness, Automatic Thoughts, and Pain Beliefs in Patients With Lumbar Disc Herniation
Completed·GGiresun University·Preclinical·NCT07683884·68 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)