VivoSeq
Other

Lymphatic Malformation

13

Pipeline Programs↗

7

Active Trials↗

10

Companies Involved↗

Lymphatic Malformation is an emerging landscape with 13 programs across 10 companies. The most active players are Avalo Therapeutics, Inc., Palvella Therapeutics, Inc., Novartis. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

43/100

Pipeline Velocity

6/100

Mech. Concentration

25/100

Completion Rate

70/100

Attrition Rate

18/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

A

Avalo Therapeutics, Inc.

1 program

Phase 1P

Palvella Therapeutics, Inc.

1 program

Phase 2Novartis logo

Novartis

1 program

Phase 2P

Protara Therapeutics

1 program

Phase 2M

Maastricht Radiation Oncology

1 program

Phase 2P

Prism Pharmaceuticals

1 program

Phase 2

Pipeline

Programs by Phase

Analysis

Trial Status

17

clinical trials

Completed7 · 41%
Recruiting6 · 35%
Terminated2 · 12%
Not yet recruiting1 · 6%
Withdrawn1 · 6%

Clinical Trials

Trial Activity

17 trials

Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients
Recruiting·WWest China Hospital·Phase 2·NCT06437158·200 enrolled
Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations
Recruiting·WWest China Hospital·Phase 2/3·NCT06673290·150 enrolled
Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age
Recruiting·PProtara Therapeutics·Phase 2·NCT05871970·38 enrolled
SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations
Recruiting·PPalvella Therapeutics, Inc.·Phase 3·NCT06239480·40 enrolled
Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
Recruiting·UUniversity Hospital, Lille·Phase 2·NCT03243019·28 enrolled
A Two-stage Double-blind, Randomized, Placebo-controlled Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.
Recruiting·Novartis logoNovartis·Preclinical·NCT05948943·232 enrolled
Injection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic Malformations
Not yet recruiting·—·Phase 2·NCT07320001·92 enrolled
Sildenafil for the Treatment of Lymphatic Malformations
Completed·SStanford University·Phase 2·NCT02335242·22 enrolled
OK432 (Picibanil) in the Treatment of Lymphatic Malformations
Completed·RRichard JH Smith·Phase 2·NCT03427619·275 enrolled
Study Evaluating the Safety and Efficacy of PTX-022 (QTORIN Sirolimus) in the Treatment of Microcystic Lymphatic Malformations
Completed·PPalvella Therapeutics, Inc.·Phase 2·NCT05050149·12 enrolled
Topical Sirolimus in Cutaneous Lymphatic Malformations
Completed·UUniversity Hospital, Tours·Phase 2·NCT03972592·55 enrolled
TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN
Completed·UUniversity Hospital, Tours·Phase 2·NCT04128722·12 enrolled
Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations
Completed·UUniversity of Iowa·Phase 2/3·NCT00010452·150 enrolled
A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations
Completed·SStanford University·Phase 1/2·NCT01290484·7 enrolled
Selenium in the Treatment of Complicated Lymphatic Malformations
Terminated·MMedical College of Wisconsin·Phase 1·NCT01212965·5 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)