VivoSeq
Psychiatry

Major Depressive Episode

12

Pipeline Programs↗

4

Active Trials↗

9

Companies Involved↗

Major Depressive Episode is an emerging landscape with 12 programs across 9 companies. The most active players are Sumitomo Pharma America, Inc., Biogen, Otsuka. 1 therapy is approved with 5 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

41/100

Pipeline Velocity

6/100

Mech. Concentration

17/100

Completion Rate

70/100

Attrition Rate

19/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Sumitomo Pharma America, Inc. logo

Sumitomo Pharma America, Inc.

1 program

Phase 2Biogen logo

Biogen

1 program

Phase 2Otsuka logo

Otsuka

1 program

Phase 3Astellas logo

Astellas

1 program

Phase 3UCB logo

UCB

1 program

Phase 3Takeda logo

Takeda

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Trial Status

16

clinical trials

Completed7 · 44%
Recruiting3 · 19%
Unknown status2 · 13%
Terminated2 · 13%
Withdrawn1 · 6%
Active, not recruiting1 · 6%

Clinical Trials

Trial Activity

16 trials

Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode
Recruiting·—·Phase 3·NCT03646058·180 enrolled
Evaluation of the Efficacy, Safety, and Tolerability of Lacosamide in Major Depressive Episodes of Bipolar Disorder Types I and II.
Recruiting·UUniversity of Sao Paulo·Phase 3·NCT07412132·40 enrolled
Belief Update: The Effects of Depression and Antidepressants in Older People
Recruiting·Hospital Center Guillaume Régnier·Preclinical·NCT07681492·62 enrolled
RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode
Active, not recruiting·MMapreg·Phase 2·NCT03870776·110 enrolled
A Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depressive Episode
Completed·Otsuka logoOtsuka·Phase 3·NCT00094432·650 enrolled
Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis
Completed·PPamlab, Inc.·N/A·NCT01001559·242 enrolled
Efficacy of Vortioxetine (Lu AA21004) in the Prevention of Relapse of Major Depressive Episodes
Completed·Lundbeck logoLundbeck·Phase 3·NCT00596817·639 enrolled
A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression
Completed·Sumitomo Pharma America, Inc. logoSumitomo Pharma America, Inc.·Phase 2·NCT03543410·344 enrolled
Study to Evaluate the Effects of Switching Different Strength Forms of FK949E in Bipolar Disorder Patients With Major Depressive Episodes
Completed·Astellas logoAstellas·Phase 3·NCT02362412·22 enrolled
A Study to Evaluate SAGE-217 in Participants With Bipolar I/II Disorder With a Current Major Depressive Episode
Completed·Biogen logoBiogen·Phase 2·NCT03692910·35 enrolled
A Study to Evaluate the Efficacy of FK949E in Bipolar Disorder Patients With Major Depressive Episodes
Completed·Astellas logoAstellas·Phase 2/3·NCT01725308·431 enrolled
A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder.
Terminated·Sumitomo Pharma America, Inc. logoSumitomo Pharma America, Inc.·Phase 3·NCT05169710·83 enrolled
A Clinical Trial to Determine the Long-term Safety and Tolerability of an Investigational Drug in People With Major Depressive Episode Associated With Bipolar I Disorder (Bipolar I Depression).
Terminated·Sumitomo Pharma America, Inc. logoSumitomo Pharma America, Inc.·Phase 3·NCT05227209·64 enrolled
A Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depressive Episode
Withdrawn·Otsuka logoOtsuka·Phase 3·NCT00338273
Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Treatment for Major Depressive Episode
Unknown status·JJiangsu Province Nanjing Brain Hospital·N/A·NCT05498441·120 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)