VivoSeq
Other

Male Infertility

16

Pipeline Programs↗

4

Active Trials↗

10

Companies Involved↗

Male Infertility is an emerging landscape with 16 programs across 10 companies. The most active players are Hyundai Pharmaceutical Co., LTD., EMD Serono, Amgen. 4 therapies are approved with 5 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

44/100

Pipeline Velocity

11/100

Mech. Concentration

22/100

Completion Rate

78/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

H

Hyundai Pharmaceutical Co., LTD.

1 program

Phase 2EMD Serono logo

EMD Serono

1 program

Phase 2Amgen logo

Amgen

1 program

Phase 2M

Milestone Pharmaceuticals Inc.

1 program

Phase 2Ferring logo

Ferring

1 program

Phase 3Eli Lilly logo

Eli Lilly

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

91%

Small molecule

20 of 22 classified programs — the dominant modality here.

9%ALL OTHERSMonoclonal antibody15%Cell therapy15%

Small molecule leads; the ring shows all 22 classified programs, each share of the total. Modality classified for 100% of 22 pipeline programs.

Analysis

Trial Status

16

clinical trials

Completed7 · 44%
Unknown status3 · 19%
Not yet recruiting2 · 13%
Withdrawn1 · 6%
Active, not recruiting1 · 6%
Terminated1 · 6%
Other1 · 6%

Clinical Trials

Trial Activity

16 trials

Assessing the Correlation Between Phospholipase C Zeta (PLCZeta) Measurements and Semen Parameters
Recruiting·FFakih IVF Fertility Center·N/A·NCT07684339·200 enrolled
FITMI - First In Treating Male Infertility
Active, not recruiting·—·Phase 2·NCT05212337·180 enrolled
Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm
Not yet recruiting·UUniversity of Nebraska·Phase 2·NCT07481370·100 enrolled
Level of DNA-fragmentation Before and After Antioxidant-based Therapies in Male Infertility: An Observational Study on Factors Influencing the Treatment Effects
Not yet recruiting·—·N/A·NCT06050031·78 enrolled
Effects of Korean Red Ginseng on Male Infertility
Completed·PPusan National University Hospital·Phase 4·NCT02202382·80 enrolled
Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial
Completed·—·Phase 2/3·NCT01304927·307 enrolled
Menevit Study: Menevit Anti-Oxidant Therapy for the Treatment of Male Infertility
Completed·RRepromed·Phase 3·NCT00100269·60 enrolled
Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
Completed·PPusan National University Hospital·Phase 4·NCT02204826·80 enrolled
Denosumab and Male Infertility: a RCT
Completed·—·Phase 2·NCT03030196·95 enrolled
Impact of Folates in the Care of the Male Infertility
Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT01407432·162 enrolled
Male Infertility Related With Post Infection Inflammatory Syndrome
Completed·AAssistance Publique - Hôpitaux de Paris·N/A·NCT01407484·200 enrolled
Aromatase Inhibitors in the Treatment of Male Infertility
Terminated·UUniversity of Utah·Phase 3·NCT00440180·20 enrolled
Androxal in Male Infertility
Withdrawn·—·Phase 2/3·NCT02160704
Oxidative Stress In Semen And Male Infertility
Unknown status·HHamad Medical Corporation·Phase 4·NCT03464656·100 enrolled
Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
Unknown status·EEuropean Hospital·Phase 1·NCT02575924·24 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)