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Other/Metformin

Metformin

10

Pipeline Programs↗

32

Active Trials↗

45

Companies Involved↗

Metformin is an early-stage landscape with 10 programs across 45 companies. The most active players are Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.. 4 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

49/100

Pipeline Velocity

39/100

Mech. Concentration

100/100

Completion Rate

90/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

1 program

Pipeline

Programs by Phase

Preclinical4

Broad-Spectrum Sunscreen (SPF ≥30)

Jinnah Postgraduate Medical Centre

Orlistat Vs Metformin

Sheffield Teaching Hospitals NHS Foundation Trust

Metformin /ml

Ranbaxy Laboratories Limited

Henagliflozin

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Phase 1

No programs

Phase 22

Metformin Pill

Fudan University

Ketofin and Metformin Alone

Assiut University

Phase 34

HDM1005 1

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

Vildagliptin

Novartis

Myoinositol

Sohag University

Metformin Glucophage M90

Medical University of Vienna

Approved

No programs

Analysis

Trial Status

378

clinical trials

Completed273 · 72%

Unknown status41 · 11%

Terminated19 · 5%

Recruiting14 · 4%

Not yet recruiting13 · 3%

Withdrawn12 · 3%

Other6 · 2%

Clinical Trials

Trial Activity

378 trials

A Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or Metformin

Recruiting·HHangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.·Phase 2·NCT07109700·216 enrolled

Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy

Recruiting·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 2·NCT06826092·110 enrolled

Precision Dosing of Metformin in Youth With T2D

Recruiting·UUniversity of California, San Francisco·Phase 1·NCT06120881·20 enrolled

Limiting AAA With Metformin (LIMIT) Trial

Recruiting·SStanford University·Phase 2·NCT04500756·314 enrolled

Metformin and Muscle Recovery

Recruiting·UUniversity of Utah·Phase 1·NCT06185179·50 enrolled

Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour

Recruiting·—·Phase 3·NCT05230758·140 enrolled

Effect of Continuing Versus Holding Metformin During Hospitalizations.

Recruiting·UUniversity of Illinois at Chicago·Phase 4·NCT06296836·300 enrolled

Clinical Study Evaluating Vildagliptin Versus Vildagliptin/Metformin on NAFLD With DM

Recruiting·—·Phase 3·NCT03925701·120 enrolled

Fish Oil, Metformin and Heart Health in PCOS

Recruiting·UUniversity of Alberta·Phase 1·NCT06424860·146 enrolled

AMPK-activation by Metformin in FSGS: AMP-FSGS

Recruiting·YYale University·Phase 1/2·NCT06090227·30 enrolled

Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity

Recruiting·UUniversity of Virginia·Phase 4·NCT06638671·20 enrolled

GDM: Insulin with or Without Metformin?

Recruiting·UUniversity of Virginia·Phase 4·NCT06781775·130 enrolled

Oral Metformin for Treating Melasma in Latin American Women

Recruiting·UUniversity of Puerto Rico·Phase 1/2·NCT06845540·30 enrolled

Efficacy of Vildagliptin Versus Metformin in Poly Cystic Ovary Syndrome

Recruiting·OOctober 6 University·Phase 2/3·NCT06142656·60 enrolled

Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans

Active, not recruiting·MMassachusetts General Hospital·Phase 1·NCT01762046·1,033 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)