VivoSeq
Other

Muscle Cramp

24

Pipeline Programs↗

1

Active Trials↗

16

Companies Involved↗

Muscle Cramp is an emerging landscape with 24 programs across 16 companies. The most active players are Vitae Pharmaceuticals Inc., an Allergan affiliate, Revance Therapeutics, Inc., Otsuka. 13 therapies are approved with 8 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

48/100

Pipeline Velocity

0/100

Mech. Concentration

16/100

Completion Rate

83/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 3R

Revance Therapeutics, Inc.

1 program

Phase 3Otsuka logo

Otsuka

1 program

Phase 3P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

Phase 3T

Tonix Pharmaceuticals, Inc.

1 program

Phase 3K

Kenvue Brands

2 programs

Approved

Pipeline

Programs by Phase

Analysis

Trial Status

12

clinical trials

Unknown status5 · 42%
Completed5 · 42%
Recruiting1 · 8%
Terminated1 · 8%

Clinical Trials

Trial Activity

12 trials

Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Recruiting·—·Phase 3·NCT02423395·100 enrolled
A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis
Completed·SSeoul National University Boramae Hospital·Phase 3·NCT01271660·60 enrolled
Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis
Completed·VVanderbilt University Medical Center·Phase 4·NCT03176966·31 enrolled
Treatment of Muscle Cramps in Patients With Liver Cirrhosis
Completed·MMayo Clinic·Phase 1·NCT01495403·3 enrolled
Mexiletine for the Treatment of Muscle Cramps in ALS
Completed·—·Phase 4·NCT01811355·23 enrolled
Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis
Completed·MMahidol University·Phase 4·NCT05724485·48 enrolled
Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients
Terminated·MMansoura University·N/A·NCT04509336·5 enrolled
Gabapentin in Treatment of Muscle Cramps in Patients With Liver Cirrhosis
Unknown status·TTanta University·Phase 3·NCT02642484·200 enrolled
Methocarbamol in Treatment of Muscle Cramps in Cirrhotic Patients
Unknown status·TTanta University·Phase 3·NCT02642874·200 enrolled
Cyclobenzaprine in Muscle Cramps With Liver Cirrhosis
Unknown status·TTanta University·Phase 3·NCT02642861·200 enrolled
Topical Magnesium and Muscle Cramps in Dialysis Patients.
Unknown status·SSir Charles Gairdner Hospital·Phase 2·NCT03082625·40 enrolled
Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis
Unknown status·TTanta University·N/A·NCT02221570·100 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)