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Metabolic & Endocrine/Obesity & Overweight

Metabolic & Endocrine

Obesity & Overweight

12

Pipeline Programs↗

89

Active Trials↗

24

Companies Involved↗

Obesity & Overweight is an emerging landscape with 12 programs across 24 companies. The most active players are Lumos Pharma.

Intelligence

Pipeline Metrics

Competitive Density

61/100

Pipeline Velocity

84/100

Mech. Concentration

33/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Lumos Pharma

1 program

Pipeline

Programs by Phase

Preclinical7

Liver-Expressed Antimicrobial Peptide 2

University Hospital, Gentofte, Copenhagen

Spermidine

Medical University of Graz

Incretin-Based Treatment

Johns Hopkins University

Anti-Obesity Medication (AOM) Treatment

Ali Aminian

GLP-1 Receptor Agonist Therapy

Gazi University

Phase 11

Dwrx5003

Daewoong Pharmaceutical Co. LTD.

Phase 24

LUM-201

Lumos Pharma

Semagludtide

Novo Nordisk

Enobosarm

Veru Inc.

Semaglutide

Novo Nordisk

Phase 3

No programs

Approved

No programs

Analysis

Modality Breakdown

78%

Small molecule

7 of 9 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 9 classified programs, each share of the total. Modality classified for 75% of 12 pipeline programs.

Analysis

Trial Status

112

clinical trials

Not yet recruiting43 · 38%

Recruiting36 · 32%

Completed23 · 21%

Active, not recruiting7 · 6%

Enrolling by invitation3 · 3%

Clinical Trials

Trial Activity

112 trials

The Effect of Daily Mixed Spice Consumption and Protein Supplementation on Muscle Mass and Function in Adults Using GLP-1 Agonists for Weight Management: A Pilot Study

Recruiting·UUniversity of California, Los Angeles·Preclinical·NCT07806838·75 enrolled

Comparison of Two-Year Weight-Loss Effectiveness of GLP-1 Receptor Agonists and Laparoscopic Sleeve Gastrectomy in the Treatment of Obesity: An Ambispective Propensity Score-Matched Cohort Study

Recruiting·YYuzuncu Yil University·N/A·NCT07901777·200 enrolled

Changes in Intestinal Permeability and Systemic Inflammation Following Fast Food Overfeeding.

Recruiting·UUniversity Hospital, Gentofte, Copenhagen·Preclinical·NCT07893743·20 enrolled

Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity (REAL-BODY)

Recruiting·Foundation for the National Institutes of Health·N/A·NCT07776678·300 enrolled

Interdisciplinary Approaches to Managing Excess Weight and Promoting Health in Older Adults: a Multimodal Intervention

Recruiting·UUniversidade Cesumar (UNICESUMAR)·Preclinical·NCT07820774·54 enrolled

A Randomised, Placebo-Controlled Trial to Evaluate the Effect of Ubiquinol on Fatigue and Muscle Strength in Healthy Adults Who Are Self-Administering GLP-1 Agonists ("Project Zest")

Recruiting·SStudySetGo·Preclinical·NCT07789106·90 enrolled

A Neuropsychobiological Approach to Optimize Patient Selection for GLP-1-based Pharmacotherapy for Weight Management Across the Binge Eating Spectrum

Recruiting·UUniversitaire Ziekenhuizen KU Leuven·Approved·NCT07870538·96 enrolled

Effect of Mazdutide on Coronary Plaque Progression in Patients With Coronary Atherosclerosis and Overweight or Obesity: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

Recruiting·CChina National Center for Cardiovascular Diseases·Approved·NCT07657676·116 enrolled

Long-term Iron Absorption and Loss in Overweight/Obese Thai Middle-aged Women

Recruiting·MMahidol University·N/A·NCT07855939·64 enrolled

Hydration Intervention to Address Dehydration Associated With Use of GLP-1 Based Medications

Recruiting·SState University of New York at Buffalo·Preclinical·NCT07641361·30 enrolled

Effect of a Concurrent Exercise Program on Muscle Quality, Body Composition, Functional Response, and Quality of Life in Individuals Undergoing Bariatric Surgery: Protocol for a Randomized Controlled Clinical Trial

Recruiting·UUniversidad Autónoma de Chile·Preclinical·NCT07423780·87 enrolled

OPTIMIZE GEN - Outcomes of Persistence and Treatment With tIrzepatide deterMined by Genetic, mIcrobiological & bEhavioral Factors in obEsity

Recruiting·JJan Kochanowski University·N/A·NCT07650149·200 enrolled

Feasibility and Acceptability of a Pediatric Referral to Summer Day Camps to Treat Obesity in Children From Low-Income Households

Recruiting·University of Central Florida·Preclinical·NCT07464015·80 enrolled

Relationship Between Collagen-Containing Supplement Use and Muscle Mass and Body Image Following Metabolic and Bariatric Surgery: A Prospective Observational Study

Recruiting·Mudanya University·N/A·NCT07809152·52 enrolled

Weight Management and Black American Women: Targeting Social Networks as a Strategy to Improve Outcomes (BRIDGE & Friends)

Recruiting·UUniversity of Illinois at Chicago·Preclinical·NCT07798557·532 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)