VivoSeq
Other

Open Fracture

1

Pipeline Programs↗

6

Active Trials↗

0

Companies Involved↗

Open Fracture is an early-stage landscape with 1 program across 0 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

24/100

Pipeline Velocity

11/100

Mech. Concentration

N/A

Completion Rate

43/100

Attrition Rate

31/100

Pipeline

Programs by Phase

Preclinical
No programs
Phase 1
No programs
Phase 2
No programs
Phase 31

Vancomycin (VAN) Treatment

University Hospital, Montpellier

Approved
No programs

Analysis

Trial Status

13

clinical trials

Terminated3 · 23%
Completed3 · 23%
Not yet recruiting3 · 23%
Recruiting2 · 15%
Active, not recruiting1 · 8%
Withdrawn1 · 8%

Clinical Trials

Trial Activity

13 trials

Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients
Recruiting·—·N/A·NCT06793644·10 enrolled
Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT
Recruiting·MMajor Extremity Trauma Research Consortium·Phase 3·NCT04678154·1,200 enrolled
Tobramycin Injection to Prevent Infection in Open Fractures
Active, not recruiting·MMassachusetts General Hospital·Phase 3·NCT04964947·600 enrolled
Volume Reduction for Open Fracture Irrigation
Not yet recruiting·IInova Health Care Services·Phase 4·NCT07437339·200 enrolled
Powdered Intrawound Vancomycin in Open Fractures Trial
Not yet recruiting·UUniversity of Manitoba·Phase 4·NCT06504992·350 enrolled
Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures
Not yet recruiting·AAtlantic Health System·Phase 3·NCT07659886·100 enrolled
Vancomycin and Tobramycin Powder Use in Acute Open Fractures
Completed·UUniversity of Utah·Phase 1·NCT05849090·10 enrolled
Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures
Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT03385304·1,638 enrolled
Acute Application of Antibiotic Powder in Open Fracture Wounds
Completed·UUniversity of Colorado, Denver·Phase 4·NCT04872400·20 enrolled
Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens
Terminated·MMercy Health Ohio·Phase 4·NCT03560232·17 enrolled
Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures
Terminated·UUniversity of Tennessee·Phase 4·NCT02400112·11 enrolled
Locally Applied Antibiotics for Infection Prophylaxis in Treatment of Open Fractures
Terminated·UUniversity of Virginia·Phase 3·NCT03705962·11 enrolled
Antibiotic Use & Open Fracture of the Lower Extremity
Withdrawn·MMethodist Health System·Phase 3·NCT05267977

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)