VivoSeq
Infectious Disease

Pyelonephritis

27

Pipeline Programs↗

1

Active Trials↗

15

Companies Involved↗

Pyelonephritis is an emerging landscape with 27 programs across 15 companies. The most active players are Paratek Pharmaceuticals Inc, MerLion Pharmaceuticals GmbH, Arbor Pharmaceuticals, Inc.. 13 therapies are approved with 5 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

0/100

Mech. Concentration

67/100

Completion Rate

75/100

Attrition Rate

18/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

P

Paratek Pharmaceuticals Inc

1 program

Phase 2M

MerLion Pharmaceuticals GmbH

1 program

Phase 2A

Arbor Pharmaceuticals, Inc.

1 program

Phase 2Bayer logo

Bayer

1 program

Phase 2Daiichi Sankyo logo

Daiichi Sankyo

1 program

Phase 2C

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

2 programs

Phase 2

Pipeline

Programs by Phase

Analysis

Trial Status

17

clinical trials

Completed9 · 53%
Unknown status4 · 24%
Terminated2 · 12%
Withdrawn1 · 6%
Recruiting1 · 6%

Clinical Trials

Trial Activity

17 trials

Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis
Recruiting·HHospital de Clinicas de Porto Alegre·Phase 4·NCT06527560·100 enrolled
Treatment's Duration of Acute Uncomplicated Pyelonephritis
Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT00873626·310 enrolled
Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women
Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT01390623·39 enrolled
Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis
Completed·MMerLion Pharmaceuticals GmbH·Phase 2·NCT01928433·225 enrolled
Treating Pyelonephritis an Urosepsis With Pivmecillinam
Completed·SSykehuset i Vestfold HF·Phase 4·NCT03282006·53 enrolled
Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old
Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT00136656·700 enrolled
Effect of Acetylcysteine in Pediatric Acute Pyelonephritis.
Completed·SShahid Beheshti University of Medical Sciences·Phase 2·NCT02080182·70 enrolled
Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis
Completed·—·Phase 4·NCT06127160·35 enrolled
Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis
Completed·—·Phase 4·NCT03179384·9 enrolled
IV or IV/PO Omadacycline vs. IV/PO Levofloxacin for the Treatment of Acute Pyelonephritis
Completed·PParatek Pharmaceuticals Inc·Phase 2·NCT03757234·201 enrolled
Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli
Terminated·AAssistance Publique - Hôpitaux de Paris·N/A·NCT01820793·9 enrolled
Short-term Antibiotic Therapy for Pyelonephritis in Childhood
Terminated·IIRCCS Burlo Garofolo·Phase 3·NCT00724256·36 enrolled
Antibiotic Prophylaxis in Children With Pyelonephritis
Withdrawn·UUniversity of Alberta·Phase 3·NCT00752375
Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli
Unknown status·MMahidol University·Phase 2·NCT02537847·96 enrolled
Efficacy of Corticosteroids in Reducing Renal Scarring in Acute Pyelonephritis in Children
Unknown status·HHamad Medical Corporation·Phase 3·NCT04654507·120 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)