VivoSeq
Respiratory

Severe Asthma

3

Pipeline Programs↗

3

Active Trials↗

2

Companies Involved↗

Severe Asthma is an early-stage landscape with 3 programs across 2 companies. The most active players are Oneness Biotech Co., Ltd., AstraZeneca. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

25/100

Pipeline Velocity

6/100

Mech. Concentration

100/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

O

Oneness Biotech Co., Ltd.

2 programs

Phase 2AstraZeneca logo

AstraZeneca

1 program

Phase 3

Pipeline

Programs by Phase

Preclinical
No programs
Phase 1
No programs
Phase 22

FB704A Placebo

Oneness Biotech Co., Ltd.

FB704A

Oneness Biotech Co., Ltd.

Phase 31

Tezepelumab

AstraZeneca

Approved
No programs

Analysis

Trial Status

5

clinical trials

Recruiting3 · 60%
Completed2 · 40%

Clinical Trials

Trial Activity

A Randomized, Placebo Controlled, Double Blind Phase IIa Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of Multiple Intravenous Doses of FB704A in Adults With Severe Asthma
Completed·OOneness Biotech Co., Ltd.·Phase 2·NCT05018299·21 enrolled
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease
Recruiting·UUniversity of Kansas Medical Center·N/A·NCT06985225·8 enrolled
The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab (the TezEx Study): a Retrospective and Prospective Observational Study
Completed·GGuy's and St Thomas' NHS Foundation Trust·N/A·NCT06666504·150 enrolled
TAPER: A Prospective, Interventional, Multicentre, Single-Arm, Phase 3b Study to Evaluate the Step-Down of Maintenance Therapy in Patients With Severe Asthma Treated With Tezepelumab
Recruiting·AstraZeneca logoAstraZeneca·Phase 3·NCT07363642·400 enrolled
An Observational Multicenter Cross-sectional Study of Patients With Uncontrolled Severe Asthma in the Population of the Russian Federation
Recruiting·AstraZeneca logoAstraZeneca·N/A·NCT06472310·5,000 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)