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Other/Smoking Cessation

Smoking Cessation

28

Pipeline Programs↗

62

Active Trials↗

21

Companies Involved↗

Smoking Cessation is an emerging landscape with 28 programs across 21 companies. 10 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

61/100

Pipeline Velocity

53/100

Mech. Concentration

25/100

Completion Rate

90/100

Attrition Rate

8/100

Pipeline

Programs by Phase

Preclinical16

Nicotine Replacement Patches

Mayo Clinic

Progesterone

Ferring

Psilocybin-Assisted Treatment

Johns Hopkins University

Sibutramine

Abbott

Champix

Jeil Pharmaceutical Co., Ltd.

Phase 11

Anti-Smoking Drug

M.D. Anderson Cancer Center

Phase 21

Tirzepatide

Eli Lilly

Phase 310

Nicotine Lozenge

Fertin Pharma A/S

Nicotine Replacement

GSK

Nicorette

University of Miami

Bupropion Hydrochloride

GSK

Nicotine Gum

Johnson & Johnson

Approved

No programs

Analysis

Modality Breakdown

96%

Small molecule

25 of 26 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 26 classified programs, each share of the total. Modality classified for 96% of 28 pipeline programs.

Analysis

Trial Status

370

clinical trials

Completed260 · 70%

Recruiting34 · 9%

Terminated19 · 5%

Unknown status19 · 5%

Active, not recruiting17 · 5%

Withdrawn10 · 3%

Other11 · 3%

Clinical Trials

Trial Activity

370 trials

Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students

Recruiting·PPoitiers University Hospital·N/A·NCT05589220·120 enrolled

The Effect of Cytisine Treatment for Smoking Cessation on Cardiovascular Function in Adult Smokers

Recruiting·UUniversity of Athens·N/A·NCT06885970·200 enrolled

Semaglutide for Post-Smoking Cessation Weight Management

Recruiting·TThe University of Texas Health Science Center, Houston·Phase 2·NCT06173778·197 enrolled

Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.

Recruiting·—·Phase 3·NCT06053567·360 enrolled

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

Recruiting·MM.D. Anderson Cancer Center·Phase 4·NCT04604509·2,010 enrolled

Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care

Recruiting·NNew York University·Phase 4·NCT06598397·500 enrolled

Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia

Recruiting·UUniversity of Virginia·N/A·NCT05660525·768 enrolled

tDCS Plus Varenicline for Smoking Cessation

Recruiting·CCentre for Addiction and Mental Health·Phase 4·NCT06798324·160 enrolled

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Recruiting·VVA Office of Research and Development·Phase 2·NCT05723588·50 enrolled

Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation

Recruiting·TThe University of Hong Kong·N/A·NCT06931054·270 enrolled

Integrating Financial Coaching and Smoking Cessation Coaching

Recruiting·NNYU Langone Health·Phase 3·NCT05154669·488 enrolled

Evaluating Smoking Cessation Interventions for PWH in South Africa

Recruiting·JJohns Hopkins University·Phase 2/3·NCT05413122·660 enrolled

Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates

Recruiting·—·Phase 4·NCT03495024·10 enrolled

Smoking Cessation and Menstrual Cycle Phase

Recruiting·CCentre for Addiction and Mental Health·Phase 4·NCT05515354·1,200 enrolled

Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation

Recruiting·OOttawa Heart Institute Research Corporation·Phase 4·NCT06832085·150 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)