VivoSeq
Infectious Disease

Syphilis

15

Pipeline Programs↗

6

Active Trials↗

2

Companies Involved↗

Syphilis is an emerging landscape with 15 programs across 2 companies. The most active players are Pfizer, Pfizer's Upjohn has merged with Mylan to form Viatris Inc.. 3 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

44/100

Pipeline Velocity

11/100

Mech. Concentration

40/100

Completion Rate

73/100

Attrition Rate

14/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Pfizer logo

Pfizer

3 programs

Phase 3P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

2 programs

Approved

Pipeline

Programs by Phase

Preclinical5

Ceftriaxone Sodium

Pfizer

Benzathine Penicillin G

National Taiwan University Hospital

Doxycycyline

Los Angeles LGBT Center

Penicillin G Potassium

National Institute of Allergy and Infectious Diseases (NIAID)

Regular Treatment for Syphilis

Ottawa Hospital Research Institute

Phase 1
No programs
Phase 21

Cefixime 400 Milligram

University of California, Los Angeles

Phase 36

Linezolid

Pfizer

Azithromycin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Amoxicillin

Global Antibiotics Research and Development Partnership

Penicillin-G-Benzathine

Pfizer

Benzathine Penicilllin G

Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia

Approved3

Doxycycline

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Ceftriaxone

Conrado Roberto Hoffmann Filho

Cefixime

Wyeth-Lederle Vaccines

Analysis

Trial Status

21

clinical trials

Completed8 · 38%
Unknown status4 · 19%
Terminated3 · 14%
Not yet recruiting2 · 10%
Recruiting2 · 10%
Active, not recruiting2 · 10%

Clinical Trials

Trial Activity

21 trials

Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline
Recruiting·NNational Taiwan University Hospital·N/A·NCT06069141·688 enrolled
PREnatal Syphilis Point-of-care ScreenING in an Urban Low-barrier Clinic: A Prospective Single Arm Feasibility Trial
Recruiting·MMcMaster University·Preclinical·NCT06829602·77 enrolled
Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis.
Active, not recruiting·—·Phase 3·NCT06877351·120 enrolled
Linezolid for Syphilis Pilot Study
Active, not recruiting·UUniversity of Southern California·Phase 2·NCT05548426·24 enrolled
Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis
Not yet recruiting·LLondon School of Hygiene and Tropical Medicine·Phase 2·NCT06921213·90 enrolled
Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates
Not yet recruiting·UUniversity of Alabama at Birmingham·Phase 4·NCT07457385·374 enrolled
Azithromycin/Bicillin Syphilis
Completed·National Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00031499·593 enrolled
Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex with Men (DaDHS)
Completed·BBritish Columbia Centre for Disease Control·Phase 4·NCT02864550·52 enrolled
Cefixime for Alternative Syphilis Treatment
Completed·UUniversity of California, Los Angeles·Phase 2·NCT03660488·58 enrolled
Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM
Completed·BBritish Columbia Centre for Disease Control·Phase 4·NCT02844634·52 enrolled
Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study
Completed·—·Phase 4·NCT02611765·64 enrolled
Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM
Completed·LLos Angeles LGBT Center·N/A·NCT02257658·30 enrolled
Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)
Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT04838717·200 enrolled
A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals
Completed·National Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000648·100 enrolled
Cefixime Versus Benzathine Penicillin G in Treatment of Early Syphilis
Terminated·—·Phase 4·NCT06907316·61 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)