VivoSeq
Other

Tetralogy of Fallot

5

Pipeline Programs↗

1

Active Trials↗

3

Companies Involved↗

Tetralogy of Fallot is an early-stage landscape with 5 programs across 3 companies. The most active players are Mylan Pharmaceuticals Inc, Otsuka, Eli Lilly. 1 therapy is approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

28/100

Pipeline Velocity

0/100

Mech. Concentration

50/100

Completion Rate

60/100

Attrition Rate

29/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Mylan Pharmaceuticals Inc logo

Mylan Pharmaceuticals Inc

1 program

Phase 1Otsuka logo

Otsuka

1 program

Phase 1Eli Lilly logo

Eli Lilly

1 program

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

88%

Small molecule

7 of 8 classified programs — the dominant modality here.

13%ALL OTHERSPeptide113%

Small molecule leads; the ring shows all 8 classified programs, each share of the total. Modality classified for 100% of 8 pipeline programs.

Analysis

Trial Status

7

clinical trials

Completed3 · 43%
Recruiting1 · 14%
Unknown status1 · 14%
Terminated1 · 14%
Withdrawn1 · 14%

Clinical Trials

Trial Activity

7 trials

Sodium-Glucose Cotransporter 2 Inhibitors for Repaired Tetralogy of Fallot Patients for Enhancement of Cardio-Pulmonary Status Trial
Recruiting·TThe University of Hong Kong·Phase 4·NCT06668389·106 enrolled
Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot
Completed·SShanghai Jiao Tong University School of Medicine·N/A·NCT01941576·120 enrolled
Effect of Parenteral Alpha-Tocopherol in the Definitive Surgery of Tetralogy of Fallot
Completed·—·Phase 1·NCT07194304·60 enrolled
The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of Fallot
Completed·NNational Cardiovascular Center Harapan Kita Hospital Indonesia·Phase 2/3·NCT05579964·66 enrolled
Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of Fallot
Terminated·CCompetence Network for Congenital Heart Defects·Phase 3·NCT00564993·53 enrolled
Exploring Asynchronism in Operated Fallot Tetralogy : A Comparative Study of Electrical and Mechanical Activation of the Right Ventricle by Three-Dimensional Analysis
Withdrawn·UUniversity Hospital, Bordeaux·Preclinical·NCT05485545
Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone System
Unknown status·—·Phase 2·NCT02010905·120 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)