LAM-001

Phase 2Small molecule

OOrphAI Therapeutics

LAM-001 is one of 13 small molecule programs targeting Bronchiolitis Obliterans. It is currently in Phase 2.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Bronchiolitis ObliteransRecruiting

Bronchiolitis ObliteransPhase 2

Recruiting

Competition

Competitive Landscape

14 competitors in Bronchiolitis Obliterans

#DrugCompanyPhaseTrials

Zithromax

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

5 2

Biaxin

Neoral

Singulair

2 5

Pulmicort

SSalix

Approved

—6

Velcade

SShilpa Grover, MD, MPH

Approved

—7

Foradil

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

—8

Esbriet

LLegacy Health System

Jakafi

2 10

Rayos

RRoxane Laboratories

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2029

Phase 2Recruiting

Pulmonary Hypertension Due to Lung Diseases

NCT05798923

Q2 2029

Phase 2Not yet recruiting

Pulmonary Hypertension

NCT07886554

Clinical

Trials by Indication[1]

Bronchiolitis Obliterans1 trial

LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.

Recruiting·SSteven Hays, MD·Phase 2·NCT06018766·30 enrolled

Pulmonary Hypertension1 trial

A Double Blind, Placebo-controlled Trial of LAM-001 for Treatment of Sarcoidosis Associated Pulmonary Hypertension (SAPH)

Not yet recruiting·IIRulya Therapeutics Inc.·Phase 2·NCT07886554·60 enrolled

Pulmonary Hypertension Due to Lung Diseases1 trial

A Phase 2, Randomized, Double-Blind, Multi-Dose, Placebo-Controlled Study to Evaluate the Efficacy and Safety of LAM-001 in Adults With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Recruiting·OOrphAI Therapeutics·Phase 2·NCT05798923·85 enrolled

Sources

References

[1]
ClinicalTrials.gov — 3 trial records for LAM-001. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — LAM-001 compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for LAM-001. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — OrphAI Therapeutics company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: OOrphAI Therapeutics

LAM-001

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2029

Q2 2029

Trials by Indication[1]

Bronchiolitis Obliterans1 trial

Pulmonary Hypertension1 trial

Pulmonary Hypertension Due to Lung Diseases1 trial

References

Drug Info

Quick Facts

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