Pneumococcal 13-valent conjugate vaccine

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Chronic Lymphocytic LeukemiaStage III Hepatocellular Carcinoma AJCC V8Meningococcal Disease

94 competitors in Chronic Lymphocytic Leukemia

#DrugCompanyPhaseTrials

1

Venclexta

AbbVie

Phase 3

512

Gazyva

Roche

Phase 3

593

Fludara

Sanofi

Phase 3

384

Calquence

AstraZeneca

Phase 3

275

Revlimid

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 3

406

Brukinsa

BBeOne Medicines

Phase 3

177

Keytruda

Merck & Co.

Phase 3

28

Adcetris

Pfizer

Phase 3

19

Beqalzi

BBeOne Medicines

Phase 3

810

Campath

GGenzyme, a Sanofi Company

Phase 2

31Show 42 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Immunogenicity5 trials

Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the US

Completed·Sanofi·Phase 3·NCT03537508·2,627 enrolled

Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers

Completed·Sanofi·Phase 3·NCT03691610·950 enrolled

A Study to Evaluate Immunogenicity and Safety of GlaxoSmithKline (GSK)'s Infanrix Hexa Vaccine (DTPa-HBV-IPV/Hib) Versus MCM Vaccine BV's Vaxelis Vaccine (DTaP5-HBV-IPV-Hib) in Healthy Infants and Toddlers

Completed·GSK·Phase 4·NCT04535037·500 enrolled

Show 2 more trials

Safety and Immunogenicity of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the Russian Federation and Mexico

Completed·Sanofi·Phase 3·NCT03630705·525 enrolled

Safety, Tolerability, and Immunogenicity of V114 in Healthy Japanese Infants (V114-028)

Completed·Merck & Co.·Phase 1·NCT03848065·133 enrolled

Chronic Lymphocytic Leukemia2 trials

Lenalidomide in Improving Immune Response to Vaccine Therapy in Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Monoclonal B Cell Lymphocytosis

Terminated·MMayo Clinic·Phase 2·NCT02309515·12 enrolled

Ibrutinib as an Immune Modulating Agent for Patients With Asymptomatic, High-risk CLL/SLL Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Active, not recruiting·JJennifer Woyach·Phase 2·NCT02518555·42 enrolled

Vaccine2 trials

Post-Marketing Study of the Safety of Prevenar (Pneumococcal Conjugate Vaccine, 7-valent)

Completed·Pfizer··NCT00683410·3,366 enrolled

A Study of a Quadrivalent Meningococcal Tetanus Protein Conjugate Vaccine in Infants and Toddlers

Completed·Sanofi·Phase 2·NCT01049035·580 enrolled

Pediatric2 trials

Safety of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers

Completed·Sanofi·Phase 3·NCT03673462·2,797 enrolled

Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants

Completed·Sanofi·Phase 2·NCT04398706·852 enrolled

Lymphoma1 trial

Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma

Completed·MMayo Clinic·Phase 1/2·NCT03035331·11 enrolled

7 more indications

Meningococcal Disease1 trial

Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants

Active, not recruiting·Sanofi·Phase 1/2·NCT06647407·750 enrolled

PREVENTION OF INVASIVE PNEUMOCOCCAL DISEASE1 trial

Study Evaluating Prevenar in the Prevention of Invasive Pneumococcal Disease (IPD) in the Paediatric Population in Spain.

Completed·Pfizer··NCT00227188·408 enrolled

Infants1 trial

NeisVac-C Single Prime Study in Infants

Completed·Pfizer·Phase 3·NCT01218451·956 enrolled

Rheumatoid Arthritis1 trial

An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Adults With Rheumatoid Arthritis

Completed·AbbVie·Phase 2·NCT02049138·493 enrolled

Phase II1 trial

A Phase IIb, Open-Label, Dose Ranging Study of 13-Valent Pneumococcal Conjugate Vaccine in Adults 55 Through 74 Years of Age Previously Vaccinated With 23-Valent Pneumococcal Polysaccharide Vaccine

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT01654263·884 enrolled

Influenza1 trial

Influenza Vaccination for Flu Prevention in Patients With Plasma Cell Disorders

Completed·EEmory University·Phase 4·NCT04080531·165 enrolled

Stage III Hepatocellular Carcinoma AJCC v81 trial

MC1641 Phase II Study Of Intratumoral Injection Of Autologous Dendritic Cells Combined With Immune Checkpoint Inhibition After High-Dose Conformal External Beam Radiotherapy In Patients With Unresectable Primary Liver Cancer

Recruiting·MMayo Clinic·Preclinical·NCT03942328·85 enrolled

Details

Drug Info

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