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Other/Acute-on-Chronic Liver Failure

Acute-on-Chronic Liver Failure

11

Pipeline Programs↗

10

Active Trials↗

8

Companies Involved↗

Acute-on-Chronic Liver Failure is an emerging landscape with 11 programs across 8 companies.

Intelligence

Pipeline Metrics

Competitive Density

42/100

Pipeline Velocity

22/100

Mech. Concentration

25/100

Completion Rate

60/100

Attrition Rate

21/100

Pipeline

Programs by Phase

Preclinical10

Carvedilol

Akero Therapeutics

G-CSF

Arog Pharmaceuticals, Inc.

Midodrine

Takeda

Entecavir

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Albumin

Laboratoire français de Fractionnement et de Biotechnologies

Phase 1

No programs

Phase 21

Huc-Msc_prolonged

Beijing 302 Hospital

Phase 3

No programs

Approved

No programs

Analysis

Trial Status

29

clinical trials

Completed9 · 31%

Not yet recruiting6 · 21%

Unknown status4 · 14%

Terminated4 · 14%

Recruiting4 · 14%

Withdrawn2 · 7%

Clinical Trials

Trial Activity

29 trials

Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure

Recruiting·—·Phase 1/2·NCT05985863·150 enrolled

Efficacy and Safety of Double Plasma Cytokine Adsorption System With Sequential Low-Dose Plasma Exchange in Treating Acute-on-Chronic Liver Failure and Sepsis: A Multi-center Randomized Controlled Study

Recruiting·TThird Affiliated Hospital, Sun Yat-Sen University·Preclinical·NCT06562803·192 enrolled

A Phase II Clinical Trial to Evaluate the Safety and Efficacy of Injectable AS1501 in the Treatment of Acute-on-chronic Liver Failure (ACLF)

Recruiting·SShenzhen Third People's Hospital·Phase 2·NCT06916585·96 enrolled

Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy: A Randomized Controlled Trial

Recruiting·IInstitute of Liver and Biliary Sciences, India·Preclinical·NCT06831565·790 enrolled

National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF)

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·Phase 1·NCT07131540·10 enrolled

Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure.

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT07422948·113 enrolled

To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months.

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06387160·480 enrolled

MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation

Not yet recruiting·TThird Affiliated Hospital, Sun Yat-Sen University·Phase 1·NCT06825572·30 enrolled

A Phase 1/2, First-in-Human Safety and Proof-of-Concept Study to Evaluate EGEN-5784 Porcine Liver (Drug Product) in Combination With the Metra® Extra-Corporeal Liver Cross-Circulation System in Participants With Acute-on-Chronic Liver Failure

Not yet recruiting·EeGenesis, INC·Preclinical·NCT07429838·20 enrolled

Evaluation of Novel Scores for Prediction of Outcomes in Patients With Acute-on-Chronic Liver Failure

Not yet recruiting·AAssiut University·N/A·NCT07734896·100 enrolled

Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02467348·80 enrolled

Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment

Completed·—·N/A·NCT03577938·516 enrolled

Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure

Completed·UUniversity of Leipzig·N/A·NCT02669680·176 enrolled

Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure

Completed·IInstitute of Liver and Biliary Sciences, India·Phase 3·NCT01383460·55 enrolled

Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04416282·70 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)