VivoSeq
Other

Acute-on-Chronic Liver Failure

16

Pipeline Programs↗

7

Active Trials↗

12

Companies Involved↗

Acute-on-Chronic Liver Failure is an emerging landscape with 16 programs across 12 companies. The most active players are Sclnow Biotechnology Co., Ltd., Rohto Pharmaceutical Co., Ltd., Beijing Baylx Biotech Co., Ltd.. 1 therapy is approved.

Intelligence

Pipeline Metrics

Competitive Density

45/100

Pipeline Velocity

11/100

Mech. Concentration

20/100

Completion Rate

57/100

Attrition Rate

24/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

S

Sclnow Biotechnology Co., Ltd.

1 program

Phase 1R

Rohto Pharmaceutical Co., Ltd.

1 program

Phase 2B

Beijing Baylx Biotech Co., Ltd.

1 program

Phase 2Grifols Therapeutics LLC logo

Grifols Therapeutics LLC

2 programs

Phase 3Gilead logo

Gilead

2 programs

PreclinicalAkero Therapeutics logo

Akero Therapeutics

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Modality Breakdown

74%

Small molecule

17 of 23 classified programs — the dominant modality here.

26%ALL OTHERSCell therapy626%

Small molecule leads; the ring shows all 23 classified programs, each share of the total. Modality classified for 100% of 28 pipeline programs.

Analysis

Trial Status

25

clinical trials

Completed8 · 32%
Not yet recruiting5 · 20%
Unknown status4 · 16%
Terminated4 · 16%
Withdrawn2 · 8%
Recruiting2 · 8%

Clinical Trials

Trial Activity

25 trials

Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure
Recruiting·—·Phase 1/2·NCT05985863·150 enrolled
Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy: A Randomized Controlled Trial
Recruiting·IInstitute of Liver and Biliary Sciences, India·Preclinical·NCT06831565·790 enrolled
Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients
Not yet recruiting·SShenzhen Third People's Hospital·Phase 2·NCT06916585·96 enrolled
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF)
Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·Phase 1·NCT07131540·10 enrolled
Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure.
Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT07422948·113 enrolled
To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months.
Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06387160·480 enrolled
MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation
Not yet recruiting·TThird Affiliated Hospital, Sun Yat-Sen University·Phase 1·NCT06825572·30 enrolled
Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.
Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02467348·80 enrolled
Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment
Completed·—·N/A·NCT03577938·516 enrolled
Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure
Completed·UUniversity of Leipzig·N/A·NCT02669680·176 enrolled
Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure
Completed·IInstitute of Liver and Biliary Sciences, India·Phase 3·NCT01383460·55 enrolled
Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04416282·70 enrolled
The Renal Safety of Tenofovir Alafenamide in HBV-related Acute-on-chronic Liver Failure: Real-World Study
Completed·XXiangya Hospital of Central South University·N/A·NCT05453448·272 enrolled
Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices
Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02583698·136 enrolled
Efficacy and Safety of Allogeneic Human Bone Marrow Mesenchymal Stem Cells for the Treatment of Patients With Acute-on-chronic Liver Failure
Completed·SSun Yat-sen University·Preclinical·NCT06740149·90 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)