G-CSF

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Breast CancerLymphomaMultiple MyelomaAcute Myeloid LeukemiaSafety and EfficacyLeukemiaSepsisNeuroblastomaNewly DiagnosedCirrhosisImmune ThrombocytopeniaMemoryTEDNeutropeniaT-Cell Acute Lymphoblastic LeukemiaEwing SarcomaSarcomaRelapsed/refractory AMLBone Marrow TransplantationFanconi AnemiaAcute-on-Chronic Liver FailureAcute Monocytic LeukemiaT-ALLStem CellsAutologous Stem Cell TransplantationMyelokathexis

706 competitors in Breast Cancer

#DrugCompanyPhaseTrials

1

G-CSF

AArog Pharmaceuticals, Inc.

Phase 3

52

Adenocard

Astellas

Preclinical

23

Methylthioninium Chloride

PProvepharm SAS

Preclinical

34

Rilvegostomig

AstraZeneca

Preclinical

15

Recombinant Human Endostatin

PPeking University Third Hospital

Preclinical

16

Tianeptine

Pfizer

Preclinical

17

Diuretic

RReprieve Cardiovascular, Inc

Preclinical

18

Naltrexone/bupropion

Novo Nordisk

Preclinical

19

4SCAR T Cells

SShenzhen Geno-Immune Medical Institute

Preclinical

110

Sertraline ODT

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1Show 21 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Lymphoma15 trials

Autologous Peripheral Stem Cell Transplant in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00345865·473 enrolled

Combination Chemotherapy With or Without Total-Body Irradiation Followed By Stem Cell Transplant in Treating Patients With Non-Hodgkin Lymphoma

Completed·—·Phase 2·NCT00559104·60 enrolled

Comparison Study of EAP and Disease-Specific Chemotherapy Regimens in Hematopoietic Stem Cell Mobilization for Lymphoma

Recruiting·—·Phase 3·NCT06520163·99 enrolled

Show 12 more trials

Intravenous AMD3100 for Collection of Autologous Peripheral Blood Stem Cells in Patients With Lymphoma

Completed·WWashington University School of Medicine·Phase 1/2·NCT00733824·61 enrolled

Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

Terminated·Pfizer·Phase 2·NCT03646123·255 enrolled

Chemotherapy Plus Ofatumumab Followed by G-CSF for Mobilization of Peripheral Blood Stem Cells in Patients With Non-Hodgkin's Lymphomas

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01329900·50 enrolled

Newly Diagnosed Mature B-ALL, Burkitt's Lymphoma and Other High-grade Lymphoma in Adults

Completed·NNicola Goekbuget·Phase 4·NCT00199082·650 enrolled

Auto Stem Cell Transplant for Lymphoma Patients

Recruiting·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT03125642·150 enrolled

Autologous and Allogenic Transplantation With Campath-1H for T-Cell Lymphoma

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT00505921·27 enrolled

Randomized Trial of G-CSF Alone Versus Intermediate-dose Ara-C Plus G-CSF Mobilization in Hodgkin's Lymphoma or Non-Hodgkin's Lymphoma

Unknown status·MMaria Sklodowska-Curie National Research Institute of Oncology·Phase 3·NCT02722733·90 enrolled

Chemotherapy With Low-Dose Radiation for Pediatric Hodgkin Lymphoma

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT00352027·81 enrolled

Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Lymphoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT02961816

Y Zevalin and BEAM in Autologous Stem Cell Transplantation (ASCT) for Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT01538472·40 enrolled

Efficacy of the HCVIDDOXIL Regimen in Patients With Newly Diagnosed Peripheral T-Cell Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00290433·55 enrolled

A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas

Completed·SSt. Jude Children's Research Hospital·Phase 1·NCT02130869·8 enrolled

Acute Myeloid Leukemia11 trials

Chemosensitization With Plerixafor Plus G-CSF in Acute Myeloid Leukemia

Completed·WWashington University School of Medicine·Phase 1/2·NCT00906945·39 enrolled

Biology and Treatment Strategy of AML in Its Subgroups: Multicenter Randomized Trial by the German Acute Myeloid Leukemia Cooperative Group (AMLCG)

Completed·UUniversity Hospital Muenster·Phase 3·NCT00266136·3,500 enrolled

Risk Adapted Treatment for Primary Acute Myeloid Leukemia (AML)

Completed·GGrupo Cooperativo de Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias·Phase 2·NCT01723657·862 enrolled

Show 8 more trials

Study of CLAG + Selinexor in Relapsed or Refractory Acute Myeloid Leukemia

Completed·WWashington University School of Medicine·Phase 1/2·NCT02416908·40 enrolled

Study of Crenolanib Combined With Chemotherapy in FLT3-mutated Acute Myeloid Leukemia Patients

Completed·AArog Pharmaceuticals, Inc.·Phase 1/2·NCT02400281·28 enrolled

Risk-adapted Therapy for Primary Acute Myeloid Leukemia

Completed·GGrupo Cooperativo de Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias·Phase 2·NCT04687098·1,034 enrolled

Lintuzumab-Ac225 in Combination with Cladribine + Cytarabine + Filgastrim + Mitoxantrone (CLAG-M) for Relapsed/Refractory Acute Myeloid Leukemia

Completed·MMedical College of Wisconsin·Phase 1·NCT03441048·26 enrolled

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

Active, not recruiting·SSt. Jude Children's Research Hospital·Phase 2·NCT03164057·206 enrolled

Cladribine in Combination With CAG in Patients With Refractory/Relapsed Acute Myeloid Leukemia

Unknown status·SSun Yat-sen University·Phase 2·NCT03181815·48 enrolled

ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia

Withdrawn·AAltor BioScience·Phase 1·NCT01478074

Safety and Efficacy of Human Myeloid Progenitor Cells (CLT-008) During Chemotherapy for Acute Myeloid Leukemia

Completed·CCellerant Therapeutics·Phase 2·NCT02282215·163 enrolled

Multiple Myeloma10 trials

Combination of G-CSF, Bortezomib, Cyclophosphamide and Dexamethasone in Patients With Multiple Myeloma

Unknown status·SSecond Affiliated Hospital of Soochow University·Phase 2·NCT02027220·60 enrolled

Comparison Study of EAP and CG Regimens for Mobilizing Hematopoietic Stem Cells in Multiple Myeloma Patients

Recruiting·—·Phase 3·NCT06520176·99 enrolled

Stem Cell Transplantation for Patients With Multiple Myeloma

Completed·UUniversity of Chicago·Phase 1·NCT01526096·30 enrolled

Show 7 more trials

Trial of Three Stem Cell Mobilization Regimens for Multiple Myeloma

Completed·WWeill Medical College of Cornell University·Phase 3·NCT01146834·47 enrolled

Lenalidomide and Dexamethasone With/Without Stem Cell Transplant in Patients With Multiple Myeloma

Completed·—·Phase 4·NCT01731886·60 enrolled

Phase I Study of Bortezomib With G-CSF for Stem Cell Mobilization in Patients With Multiple Myeloma

Completed·WWashington University School of Medicine·Phase 1·NCT02220608·10 enrolled

Randomized Trial of G-CSF Alone Versus Intermediate-dose Ara-C Plus G-CSF Mobilization in Multiple Myeloma Patients.

Completed·MMaria Sklodowska-Curie National Research Institute of Oncology·Phase 3·NCT01908621·90 enrolled

A Pharmacodynamic Study of the Apheresis Product of Multiple Myeloma Patients Undergoing Quad-induction Followed by Motixafortide + G-CSF Mobilization

Completed·WWashington University School of Medicine·Phase 1·NCT06547112·20 enrolled

A Randomized Trial to Compare Busulfan + Melphalan 140 mg/m2 With Melphalan 200 mg/m2 as Preparative Regimen for Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT01413178·205 enrolled

Ph2, Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

Completed·GGPCR Therapeutics, Inc.·Phase 2·NCT05561751·30 enrolled

Acute Lymphoblastic Leukemia9 trials

Disrupting the Bone Marrow Microenvironment With G-CSF in Acute Lymphoblastic Leukemia

Completed·WWashington University School of Medicine·Phase 1·NCT01331590·13 enrolled

German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003)

Completed·GGoethe University·Phase 4·NCT00198991·1,883 enrolled

Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab

Completed·JJohann Wolfgang Goethe University Hospital·Phase 4·NCT00199004·60 enrolled

Show 6 more trials

Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00003700·163 enrolled

German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99)

Completed·GGoethe University·Phase 4·NCT00199056·225 enrolled

Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00890656·90 enrolled

Modified Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) Program for Acute Lymphoblastic Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00671658·220 enrolled

Cladribine in Combination With GAP in Patients With Refractory/Relapsed Acute Lymphoblastic Leukemia

Unknown status·SSun Yat-sen University·Phase 2·NCT03318419·50 enrolled

Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01319981·31 enrolled

Leukemia8 trials

Fludarabine and Cyclophosphamide Followed by Peripheral Stem Cell Transplant in Treating Patients With Leukemia or Lymphoma

Completed·CCancer and Leukemia Group B·Phase 2·NCT00006252·47 enrolled

Treatment of Relapsed or Refractory Acute Myeloblastic Leukemia

Completed·PPETHEMA Foundation·Phase 1/2·NCT01435343·55 enrolled

Study of Hyper-CVAD Plus Imatinib Mesylate for Philadelphia-Positive Acute Lymphocytic Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00038610·54 enrolled

Show 5 more trials

Rituximab and Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) for Burkitt's and Burkitt's -Like Leukemia/Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00669877·56 enrolled

Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemia

Completed·CCellerant Therapeutics·Phase 1/2·NCT01297543·45 enrolled

RAD001 Study in Treatment of Relapsed or Refractory Acute Lymphocytic Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00968253·24 enrolled

Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies

Recruiting·UUniversity of Alabama at Birmingham·Phase 1·NCT07044544·20 enrolled

Granulocyte-colony Stimulating Factor (G-CSF) and Plerixafor Plus Sorafenib for Acute Myelogenous Leukemia (AML) With FLT3 Mutations

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT00943943·33 enrolled

105 more indications

Transplantation7 trials

Study of Unrelated Cord Blood Transplantation Using Tacrolimus and Sirolimus

Completed·MMassachusetts General Hospital·Phase 2·NCT00133367·32 enrolled

DCEP in Combination With Thalidomide as Salvage Therapy for Post Transplantation Relapse

Completed·UUniversity of Arkansas·Phase 2·NCT00083681·180 enrolled

Allogeneic Transplantation Using Timed Sequential Busulfan and Fludarabine Conditioning

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01572662·201 enrolled

Show 4 more trials

Busulfan Monotherapy as Conditioning for Autologous Hematopoietic Progenitor Cell Transplantation

Terminated·HH. Lee Moffitt Cancer Center and Research Institute·N/A·NCT00363467·3 enrolled

Induction With or Without Granulocyte Colony-Stimulating Factor in AML Transplantation in AML

Completed·TTurkish Leukemia Study Group·Phase 3·NCT00820976·260 enrolled

Mismatched Transplantation Using High-dose Post-transplant Cyclophosphamide

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01010217·176 enrolled

Allogeneic Transplantation From Related Haploidentical Donors

Completed·SStanford University·Phase 2·NCT00185692·16 enrolled

Breast Cancer5 trials

Phase III Comparison of Adjuvant Chemotherapy W/High-Dose Cyclophosphamide Plus Doxorubicin (AC) vs Sequential Doxorubicin Fol by Cyclophosphamide (A-C) in High Risk Breast Cancer Patients With 0-3 Positive Nodes (Intergroup, CALGB 9394)

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00590785·60 enrolled

A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00001384·35 enrolled

A Phase I/II Study of ABI-007 (Abraxane®, Nab®-Paclitaxel)and Vinorelbine in Patients With Stage IV (Metastatic) Breast Cancer

Terminated·Bristol-Myers Squibb·Phase 1/2·NCT00140140·16 enrolled

Show 2 more trials

Study of Sacituzumab Govitecan With Atropine to Improve Tolerability in Advanced TNBC and HR+/HER2- Breast Cancer

Not yet recruiting·MMedSIR·Phase 2·NCT07367178·30 enrolled

Adjuvant Therapy for High-Risk Breast Cancer With Wkly Adriamycin & Oral Cytoxan With G-CSF for 12 Wks; Wkly Taxol x 12

Completed·UUniversity of Washington·Phase 2·NCT00194753·80 enrolled

Neuroblastoma4 trials

131I-Metaiodobenzylguanidine (131I-MIBG) Therapy for Relapsed/Refractory Neuroblastoma

No longer available·UUniversity of Texas Southwestern Medical Center··NCT03649438

MIBG for Refractory Neuroblastoma and Pheochromocytoma

Completed·MMasonic Cancer Center, University of Minnesota·N/A·NCT01850888·15 enrolled

Intensive Chemo-Radiotherapy With Peripheral Blood Progenitor Cell Rescue for Children With Advanced Neuroblastoma and Sarcomas

Completed·—·Phase 2·NCT00165139·20 enrolled

Show 1 more trial

High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

Recruiting·SSt. Anna Kinderkrebsforschung·Phase 3·NCT01704716·3,300 enrolled

Cirrhosis4 trials

Effect of Single vs Repeated Cycles of a Combination of Granulocyte Colony Stimulating Factor and Darbepoetin vs Standard Medical Treatment on Immunometabolic Profile in Patient With Early Decompensated Cirrhosis.

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT07002827·60 enrolled

A Trial to Study the Influence of Growth Factors on Bone Marrow and Hepatic Regeneration in Patients With Decompensated Cirrhosis.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT01902511·60 enrolled

GCSF Therapy in Decompensated Cirrhosis - A Double Blinded RCT

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT03911037·70 enrolled

Show 1 more trial

G-CSF in Decompensated Cirrhosis: an Open Label Trial

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT03415698·100 enrolled

Myelodysplastic Syndrome4 trials

Thymoglobulin and Cyclosporine in Patients With Aplastic Anemia or Myelodysplastic Syndrome

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00806598·53 enrolled

Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) in Combination With Azacitidine for the Treatment of Myelodysplastic Syndrome (MDS)

Completed·WWashington University School of Medicine·Phase 1·NCT01065129·28 enrolled

Treatment of Myelodysplastic Syndrome (MDS) With Cytokine-Immunotherapy for Low-Risk MDS

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00520468·15 enrolled

Show 1 more trial

Alloreactive NK Cells for Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT00402558·15 enrolled

Hepatitis4 trials

Efficacy of G-CSF in the Management of Steroid Non-responsive Severe Alcoholic Hepatitis

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT01820208·28 enrolled

Granulocyte Colony Stimulating Factor Four Week Plus N-Acetyl Cysteine in Severe Alcoholic Hepatitis

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 4·NCT05840640·66 enrolled

G-CSF Plus NAC In Severe Alcoholic Hepatitis

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 4·NCT02971306·60 enrolled

Show 1 more trial

Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid

Terminated·—·Phase 3·NCT02442180·64 enrolled

Neutropenia3 trials

Comparison of G-CSF & Antibiotics Versus Antibiotics Alone in Resolution of Febrile Neutropenia

Not yet recruiting·KKing Edward Medical University·Phase 4·NCT06988826·150 enrolled

Phase II Study of DA-3031(PEG-G-CSF) in Chemotherapy-induced Neutropenia

Completed·DDong-A ST Co., Ltd.·Phase 2·NCT01923545·61 enrolled

Phase III Study of DA-3031(PEG-G-CSF) in Chemotherapy-induced Neutropenia

Completed·DDong-A ST Co., Ltd.·Phase 3·NCT01674855·74 enrolled

Fanconi Anemia3 trials

HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

Recruiting·—·Phase 2·NCT02143830·70 enrolled

Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and Plerixafor

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 1/2·NCT02678533·4 enrolled

A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients With Fanconi Anemia

Terminated·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT03600909·3 enrolled

Chemotherapy3 trials

Chemotherapy and G-CSF for Mobilization

Completed·IInsel Gruppe AG, University Hospital Bern·Phase 2·NCT03442673·137 enrolled

Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML

Unknown status·AArog Pharmaceuticals, Inc.·Phase 3·NCT03250338·322 enrolled

Pilot Study of Crenolanib Combined With Standard Salvage Chemotherapy in Subjects With R/R AML

Completed·AArog Pharmaceuticals, Inc.·Phase 1/2·NCT02626338·16 enrolled

Efficacy3 trials

Efficacy of G-CSF-Priming in Elderly AML Patients

Unknown status·JJohann Wolfgang Goethe University Hospital·Phase 4·NCT00199147·250 enrolled

The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis

Unknown status·SSir Run Run Shaw Hospital·N/A·NCT02855632·240 enrolled

Efficacy of R-CHOP vs R-CHOP/R-DHAP in Untreated MCL

Unknown status·EEuropean Mantle Cell Lymphoma Network·Phase 3·NCT00209222·360 enrolled

Stem Cell Transplant3 trials

Safety and Efficacy of Pentostatin and Low Dose TBI With Allogenic Peripheral Blood Stem Cell Transplant

Completed·UUniversity of Nebraska·Phase 2·NCT00571662·76 enrolled

Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00053196·82 enrolled

Thiotepa-Clofarabine-Busulfan With Allogeneic Stem Cell Transplant for High Risk Malignancies

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00857389·60 enrolled

Stem Cell Transplantation3 trials

Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1/2·NCT04370795

Stem Cell Transplantation for Stiff Person Syndrome (SPS)

Terminated·NNorthwestern University·Phase 1/2·NCT02282514·23 enrolled

Zevalin-Containing Nonmyeloablative Conditioning for Stem Cell Transplantation (SCT)

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01490723·20 enrolled

Bone Marrow Transplantation2 trials

HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide

Completed·CCenter for International Blood and Marrow Transplant Research·Phase 2·NCT02793544·80 enrolled

Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure

Recruiting·PPaul Szabolcs·Phase 1/2·NCT03500731·8 enrolled

Allogeneic Stem Cell Transplantation2 trials

Chemotherapy Followed by Allogeneic Stem Cell Transplantation for Hematologic Malignancies

Completed·—·N/A·NCT00741455·18 enrolled

Planned Donor Lymphocyte Infusion (DLI) After Allogeneic Stem Cell Transplantation (SCT)

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT01518153·16 enrolled

Aplastic Anemia2 trials

Stem Cell Mobilization Potential in Patients With Aplastic Anemia in Remission

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 1·NCT00011830·20 enrolled

Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502)

Completed·MMedical College of Wisconsin·Phase 2·NCT02918292·32 enrolled

Myelodysplastic Syndromes2 trials

SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia

Completed·PPETHEMA Foundation·Phase 4·NCT00487448·200 enrolled

A Clinical Trial of Omacetaxine, Azacitidine, and Growth-Colony Stimulating Factor (G-CSF) for Myelodysplastic Syndromes (MDS)

Withdrawn·UUniversity of Florida·Phase 1/2·NCT02835794

G-CSF2 trials

Granulocyte Colony-stimulating Factor (G-CSF) Plus or Minus AMD3100 for Engraftment Post Allogeneic Transplant

Completed·WWashington University School of Medicine·Phase 1·NCT01026987·29 enrolled

Intrauterine G-CSF Administration in RIF

Completed·GGurgan Clinic·N/A·NCT03783208·157 enrolled

Hematological Malignancies2 trials

Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT00566696·73 enrolled

Stem Cell Transplantation for Hematological Malignancies

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 2/3·NCT00176839·11 enrolled

Hematopoietic Stem Cell Transplant2 trials

Hematopoietic Stem Cell Transplant in Devic's Disease

Completed·NNorthwestern University·Phase 1/2·NCT00787722·13 enrolled

The Value of Peripheral Blood CD34+ Cell Dynamics Monitoring in Autologous Hematopoietic Stem Cell Transplant Mobilization

Unknown status·ZZhongnan Hospital·Phase 1·NCT05970185·40 enrolled

Myocardial Infarction2 trials

Myocardial Regeneration and Angiogenesis in Myocardial Infarction With G-CSF and Intra-Coronary Stem Cell Infusion-3-DES

Completed·SSeoul National University Hospital·Phase 2·NCT00291629·96 enrolled

The Effect of Granulocyte Colony Stimulating Factor (G-CSF) on Myocardial Function After Acute Anterior Myocardial Infarction, a Prospective Double Blind Randomized Placebo Controlled Study

Completed·SShiraz University of Medical Sciences·N/A·NCT00756756·20 enrolled

Intravenous1 trial

Neuroregenerative Potential of Intravenous G-CSF and Autologous Peripheral Blood Stem Cells

Completed·HHanyang University Seoul Hospital·Phase 1/2·NCT02983708·57 enrolled

Cirrhosis of Liver1 trial

Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT02451033·65 enrolled

T-cell acute lymphoblastic leukemia1 trial

A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia

Not yet recruiting·MM.D. Anderson Cancer Center·Phase 1·NCT07428486·24 enrolled

Mantle Cell Lymphoma1 trial

Rituximab and Combination Chemotherapy in Treating Patients With Previously Untreated Mantle Cell Lymphoma

Completed·UUniversity of Miami·Phase 2·NCT00878254·25 enrolled

Elderly Patients1 trial

R-CHOP Versus R-mini-CEOP in Elderly Patients(>65)With DLBCL

Completed·FFondazione Italiana Linfomi - ETS·Phase 3·NCT01148446·226 enrolled

NMO Spectrum Disorder1 trial

Autologous Transplant To End NMO Spectrum Disorder

Withdrawn·NNorthwestern University·Phase 2/3·NCT03829566

Relapsed/Refractory AML1 trial

CLAG+VEN vs CLAG in the Treatment of Relapsed/Refractory AML

Not yet recruiting·NNanfang Hospital, Southern Medical University·Phase 4·NCT06763666·172 enrolled

Stem Cell1 trial

G-CSF Versus G-CSF Plus GM-CSF for Stem Cell Mobilization in NHL Patients

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00499343·84 enrolled

Graft Versus Host Disease1 trial

Fucosylated T Cells for Graft Versus Host Disease (GVHD) Prevention

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT02423915·5 enrolled

Diamond-Blackfan anemia1 trial

Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00011505·15 enrolled

Acute Monocytic Leukemia1 trial

Treateament of Newly Diagnosed Acute Monocytic Leukemia in Children

Recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2/3·NCT05313958·43 enrolled

Safety and Efficacy1 trial

The Safety and Efficacy of the Regimen of Thiotepa + Fludarabine +Granulocyte Colony-Stimulating Factor+ Cytarabine + Busulfan in Single Unrelated Umbilical Cord Blood Transplantation

Not yet recruiting·IInstitute of Hematology & Blood Diseases Hospital, China·Phase 2·NCT07441967·44 enrolled

Mesenchymal Stem Cells1 trial

Cord Blood Expansion on Mesenchymal Stem Cells

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT00498316·98 enrolled

Relapsed or Refractory Hematologic Malignancies1 trial

Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following Prior Transplantation

Terminated·SSt. Jude Children's Research Hospital·Phase 2·NCT02259348·12 enrolled

Crohn's Disease1 trial

G-CSF to Treat Crohn's Disease

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00025805·23 enrolled

Dendritic Cell1 trial

A Comparison of Dendritic Cell Content and T-Cell Phenotype Between Granulocyte Colony-Stimulating Factor (G-CSF) or G-CSF + Granulocyte Macrophage (GM)-CSF

Terminated·EEmory University·Phase 2·NCT00208949·50 enrolled

Small Cell Lung Cancer1 trial

Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00057837·140 enrolled

Parkinson's Disease1 trial

Study of the Neuro-protective Effect of Granulocyte-colony Stimulating Factor on Early Stage Parkinson's Disease

Terminated·—·Phase 2·NCT01227681·4 enrolled

Recurrent or Refractory Solid Tumors1 trial

Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors

Completed·CChildren's Oncology Group·Phase 1·NCT00003597·16 enrolled

Adjuvant1 trial

Autologous CD133(+) Cells as an Adjuvant to Below the Knee Percutaneous Transluminal Angioplasty

Unknown status·SShanghai 10th People's Hospital·Phase 1·NCT02915796·345 enrolled

Lymphoblastic Lymphoma1 trial

German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults

Completed·JJohann Wolfgang Goethe University Hospital·Phase 4·NCT00199017·75 enrolled

Memory1 trial

Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

Active, not recruiting·SSt. Jude Children's Research Hospital·Phase 2·NCT02790515·170 enrolled

Osteosarcoma1 trial

A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma With Doxorubicin, Ifosfamide, Etoposide, and Cisplatin With Early Metabolic Assessment of Response

Terminated·UUniversity of Chicago·Phase 1·NCT01258634·2 enrolled

Acute-on-Chronic Liver Failure1 trial

Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure

Completed·UUniversity of Leipzig·N/A·NCT02669680·176 enrolled

T-ALL1 trial

VHAG in Treating R/R T-ALL/LBL

Recruiting·FFirst Affiliated Hospital of Zhejiang University·Phase 2·NCT06742463·50 enrolled

Germ Cell Tumor1 trial

Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors

Active, not recruiting·AAlliance for Clinical Trials in Oncology·Phase 3·NCT02375204·420 enrolled

Ewing sarcoma1 trial

Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma

Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT01864109·83 enrolled

Severe Aplastic Anemia1 trial

Randomized Study In Severe Aplastic Anemia Patients Receiving Atg, Cyclosporin A, With Or Without G-CSF (SAA-G-CSF)

Terminated·EEuropean Society for Blood and Marrow Transplantation·Phase 3·NCT01163942·205 enrolled

B-cell Malignancies1 trial

Dose Adjusted EPOCH-R, to Treat Mature B Cell Malignancies

Completed·—·Phase 1·NCT01760226·4 enrolled

Diabetic Foot1 trial

A Clinical Trial on Diabetic Foot Using Peripheral Blood Derived Stem Cells for Treating Critical Limb Ischemia

Unknown status·BBeike Biotech India Pvt.ltd·Phase 1/2·NCT00922389·36 enrolled

Systemic Sclerosis1 trial

Stem Cell Transplant to Treat Patients With Systemic Sclerosis

Completed·—·Phase 1·NCT00058578·24 enrolled

Rhabdomyosarcoma1 trial

New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00001335·90 enrolled

Vinorelbine1 trial

Effects of Granulocyte Colony-stimulating Factor (G-CSF), Trastuzumab, and Vinorelbine on Immune Cell Function

Terminated·—·Phase 2/3·NCT00169104·23 enrolled

Malignant Tumor1 trial

G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor

Unknown status·XXinhua Hospital, Shanghai Jiao Tong University School of Medicine·Phase 4·NCT02933333·405 enrolled

Suicide1 trial

Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT01875237·3 enrolled

CAR1 trial

REaCT Integrated Consent Model to Compare Two Standard of Care Regimens

Completed·OOttawa Hospital Research Institute·Phase 4·NCT02173262·142 enrolled

Brentuximab Vedotin1 trial

Brentuximab Vedotin as Consolidation Treatment in Patients With Stage I/II HL and PET Positivity After 2 Cycles of ABVD

Completed·TThe Lymphoma Academic Research Organisation·Phase 2·NCT02298283·40 enrolled

Multiple Sclerosis1 trial

Maximizing Outcome of Multiple Sclerosis Transplantation

Terminated·NNorthwestern University·Phase 3·NCT03342638·66 enrolled

Pancreatic Cancer1 trial

PRIMUS 001: A Study Looking at Two Different Chemotherapy Regimens in Patients With Metastatic Pancreatic Cancer

Unknown status·JJudith Dixon-Hughes·Phase 2·NCT04151277·500 enrolled

Hot flashes1 trial

A Study of the Safety and Effect of Repeated Administration of G-CSF on Hot Flashes in Postmenopausal Women

Completed·MMenoGeniX, Inc.·Phase 1·NCT03640754·61 enrolled

Acute Myeloblastic Leukaemia1 trial

Treatment of Adults Aged Up to 60 Years With De Novo Acute Myeloblastic Leukaemia,Secondary AML, or RAEB-T

Unknown status·HHannover Medical School·Phase 2/3·NCT00209833·200 enrolled

Immune Thrombocytopenia1 trial

Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia

Recruiting·FFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico··NCT05931718·200 enrolled

Cancers1 trial

Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00003838·202 enrolled

CNS Tumors1 trial

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

Completed·MMasonic Cancer Center, University of Minnesota·N/A·NCT01505569·44 enrolled

Premature Ovarian Failure1 trial

Autologous Bone Marrow Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failure

Unknown status·IInstituto de Investigacion Sanitaria La Fe·Phase 4·NCT03535480·20 enrolled

Advanced Cancer1 trial

A Study of Prexasertib (LY2606368) With Chemotherapy or Targeted Agents in Participants With Advanced Cancer

Completed·Eli Lilly·Phase 1·NCT02124148·167 enrolled

Hematopoietic Cell Transplantation (HCT)1 trial

Nonmyeloablative Hematopoietic Cell Transplantation (HCT) for Patients With Hematologic Malignancies Using Related, HLA-Haploidentical Donors: A Pilot Trial of Peripheral Blood Stem Cells (PBSC) as the Donor Source

Completed·—·Phase 1·NCT02167958·28 enrolled

Newly Diagnosed1 trial

Comparing the Efficacy of VHAG and Traditional Chemotherapy Regimens in Newly Diagnosed ETP-ALL

Recruiting·FFirst Affiliated Hospital of Zhejiang University·Phase 3·NCT06361329·81 enrolled

Gemcitabine1 trial

High-Dose Gemcitabine, Busulfan and Melphalan With Hematopoietic-Cell Support for Patients With Poor-Risk Myeloma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01237951·75 enrolled

Autologous Stem Cell Transplantation1 trial

Autologous Stem Cell Transplantation for Crohn's Disease

Recruiting·PPaul Szabolcs·Phase 1/2·NCT00692939·20 enrolled

APL1 trial

Alloreactive Haploidentical Natural Killer (NK) Cells With Busulfan and Fludarabine/ATG

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01390402·6 enrolled

Ovarian Cancer1 trial

A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin With G-CSF for Patients With Newly Diagnosed Advanced Stage Ovarian Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00001426·66 enrolled

Metastatic Prostate Cancer1 trial

Pilot Study of Mobilization and Treatment of Disseminated Tumor Cells in Men With Metastatic Prostate Cancer

Terminated·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 1·NCT02478125·3 enrolled

First-line Treatment1 trial

PD-1 Inhibitor Plus G-CSF in Recurrent/Metastatic NPC With First-line Treatment Failure

Unknown status·SSun Yat-sen University·Phase 2·NCT05222035·68 enrolled

Clinical Trial1 trial

Clinical Trial of Ara-C, Aclarubicin Combined With PEG-G-CSF for Initial Treatment of AML Patients

Unknown status·SShandong University·Phase 2·NCT03045627·120 enrolled

Peripheral Artery Disease1 trial

Stem Cell Mobilization by G-CSF to Treat Severe Peripheral Artery Disease

Completed·WWashington University School of Medicine·Phase 1·NCT00797056·32 enrolled

Squamous Cell Carcinoma1 trial

Combination Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Completed·—·Phase 2·NCT00139230·30 enrolled

Cerebral Palsy1 trial

G-CSF and Autologous Cord Blood Infusion in Cerebral Palsy

Unknown status·HHanyang University Seoul Hospital·Phase 2·NCT02866331·88 enrolled

Alzheimer's Disease1 trial

Efficacy and Safety of Filgrastim in Alzheimer's Disease

Completed·UUniversity of South Florida·Phase 1/2·NCT01617577·8 enrolled

Renal Cell Carcinoma1 trial

Doxorubicin and Gemcitabine in Treating Patients With Locally Recurrent or Metastatic Unresectable Renal Cell Carcinoma

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00068393·39 enrolled

Liver Transplant1 trial

Granulocyte-Colony Stimulating Factor (G-CSF) as Optimizing Therapy for Pediatric Liver Transplantation

Completed·FFakultas Kedokteran Universitas Indonesia·Phase 3·NCT04113317·52 enrolled

Non-Small Cell Lung Cancer1 trial

Study of Pembrolizumab (MK-3475) Monotherapy in Advanced Solid Tumors and Pembrolizumab Combination Therapy in Advanced Non-small Cell Lung Cancer/ Extensive-disease Small Cell Lung Cancer (MK-3475-011/KEYNOTE-011)

Completed·Merck & Co.·Phase 1·NCT01840579·57 enrolled

Stem Cells1 trial

Protocol Title: Safety and Feasibility of Autologous CD34+ Hematopoietic Stem Cells Mobilization and Apheresis in Participants With RUNX1 Familial Platelet Disorder

Recruiting·MM.D. Anderson Cancer Center·Phase 1·NCT06414889·4 enrolled

Hypereosinophilic syndrome1 trial

2-Chlorodeoxyadenosine and Cytarabine in Patients With Idiopathic Hypereosinophilic Syndrome (HES)

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00483067·13 enrolled

Acute Myocardial Infarction1 trial

Bone Marrow Stem Cell Mobilisation Therapy for Acute Myocardial Infarction (AMI)(REVIVAL-2)

Completed·DDeutsches Herzzentrum Muenchen·Phase 4·NCT00126100·114 enrolled

Prostate Cancer1 trial

Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer

Completed·Sanofi·Phase 4·NCT01649635·45 enrolled

Hematologic Malignancy1 trial

Haploidentical Donor Hematopoietic Progenitor Cell and NK Cell Transplantation for Hematologic Malignancy

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT01807611·82 enrolled

Myasthenia Gravis1 trial

Hematopoietic Stem Cell Therapy for Patients With Refractory Myasthenia Gravis

Terminated·NNorthwestern University·Phase 1·NCT00424489·9 enrolled

Relapsed or Refractory1 trial

Vorinostat With Gemcitabine, Busulfan, and Melphalan With Stem Cell Transplant (SCT) in Relapsed or Refractory Lymphoid Malignancies

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT01421173·78 enrolled

Refractory AML1 trial

Selinexor (KPT-330) Plus FLAG-Ida for the Treatment of Relapsing/Refractory AML

Completed·PPETHEMA Foundation·Phase 1·NCT03661515·16 enrolled

Infusion1 trial

Infusion of Expanded Cord Blood T Cells

Withdrawn·MM.D. Anderson Cancer Center·Phase 1·NCT00972101

Miscarriage1 trial

Use of G-CSF for the Treatment of Unexplained Recurrent Miscarriage

Completed·UUniversity of Florence·Phase 4·NCT00772122·68 enrolled

Granulocyte Colony Stimulating Factor1 trial

Granulocyte Colony Stimulating Factor (G-CSF) After Salvage Chemotherapy in Refractory AML

Unknown status·SSeoul St. Mary's Hospital·Phase 2/3·NCT02427919·56 enrolled

Idiopathic Inflammatory Myopathy1 trial

Stem Cell Transplantation in Idiopathic Inflammatory Myopathy Diseases

Terminated·NNorthwestern University·Phase 1·NCT00278564·7 enrolled

Pregnancy1 trial

Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization)

Completed·CCenter for Human Reproduction·Phase 1/2·NCT01202656·129 enrolled

Endometrial1 trial

Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF

Terminated·CCenter for Human Reproduction·Phase 1/2·NCT01202643·12 enrolled

AIN1 trial

Autologous Transplant Targeted Against Crohn's

Withdrawn·NNorthwestern University·Phase 2·NCT04154735

Efficacy and Safety1 trial

Efficacy and Safety of Cladribine in Combination With CAG in Newly Diagnosed Unfit Patients With AML

Unknown status·SSun Yat-sen University·Phase 2·NCT04254640·34 enrolled

TED1 trial

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

Recruiting·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT03579875·48 enrolled

Hematologic Disorder1 trial

Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorders

Completed·—·Phase 2·NCT00636909·25 enrolled

Chronic Myelogenous Leukemia1 trial

Autologous Stem Cell Transplants for Chronic Myelogenous Leukemia

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT00446173

Vasculitis1 trial

Hematopoietic Stem Cell Support in Vasculitis

Terminated·NNorthwestern University·Phase 1·NCT00278512·7 enrolled

Hematologic Malignancies1 trial

Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen

Terminated·SSt. Jude Children's Research Hospital·Phase 2·NCT02199041·24 enrolled

AML1 trial

AML Therapy With Irradiated Allogeneic Cells

Terminated·RRutgers, The State University of New Jersey·N/A·NCT02105116·6 enrolled

Unspecified1 trial

Study of Bortezomib in Combination With Cyclophosphamide and Rituximab

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00958256·22 enrolled

Details

Drug Info

Related News