VivoSeq
Gastroenterology

Anal Fissure

27

Pipeline Programs↗

3

Active Trials↗

16

Companies Involved↗

Anal fissure is an emerging landscape with 27 programs across 16 companies. The most active players are Omnivium, RDD Pharma Ltd, Vitae Pharmaceuticals Inc., an Allergan affiliate. 11 therapies are approved with 4 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

51/100

Pipeline Velocity

0/100

Mech. Concentration

38/100

Completion Rate

78/100

Attrition Rate

16/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

O

Omnivium

1 program

Phase 1R

RDD Pharma Ltd

1 program

Phase 2V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

Phase 2AbbVie logo

AbbVie

1 program

Phase 2V

Ventrus Biosciences, Inc

1 program

Phase 3

Pipeline

Programs by Phase

Preclinical4

Botulinum Toxin Type a

Revance Therapeutics, Inc.

Glyceryl - Trinitrate

Procris Pharmaceuticals

Botulinum Toxins

Yale University

Minoxidil

Pfizer

Phase 12

Isosorbide Mononitrate

Omnivium

E-CEL UVEC

Weill Medical College of Cornell University

Phase 26

Diltiazem

Bausch Health Americas, Inc.

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Nifedipine

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Sucralfate

AbbVie

Azadirachtin

Suez Canal University

Phase 34

Nitroglycerin

Viatris Specialty LLC

Cellegesic

Forest Laboratories

VEN 307

Ventrus Biosciences, Inc

Rectogesic

Hospital General Universitario Elche

Approved11

Isosorbide Dinitrate

AstraZeneca

Polyethylene Glycol

Bayer

Lactulose

Solvay Pharmaceuticals

Plantago Ovata

Solvay Pharmaceuticals

Proctocella

University of Roma La Sapienza

Analysis

Modality Breakdown

97%

Small molecule

36 of 37 classified programs — the dominant modality here.

3%ALL OTHERSGene therapy13%

Small molecule leads; the ring shows all 37 classified programs, each share of the total. Modality classified for 100% of 38 pipeline programs.

Analysis

Trial Status

31

clinical trials

Completed18 · 58%
Unknown status5 · 16%
Terminated3 · 10%
Recruiting3 · 10%
Withdrawn2 · 6%

Clinical Trials

Trial Activity

31 trials

E-CEL UVEC Treatment for Anal Fissures
Recruiting·WWeill Medical College of Cornell University·Phase 1·NCT06456073·12 enrolled
Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure
Recruiting·—·Phase 2·NCT04153032·183 enrolled
Complex Treatment of a Chronic Anal Fissure
Recruiting·SState Scientific Centre of Coloproctology, Russian Federation·Phase 4·NCT03855046·340 enrolled
Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure
Completed·OOnze Lieve Vrouwe Gasthuis·Phase 4·NCT00827736·73 enrolled
Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure
Completed·MMansoura University·N/A·NCT03528772·62 enrolled
The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure
Completed·RRDD Pharma Ltd·Phase 2/3·NCT02527109·339 enrolled
Efficacy Study of Dysport® in the Treatment of Anal Fissure.
Completed·Ipsen logoIpsen·Phase 2·NCT00210444·168 enrolled
A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures
Completed·FForest Laboratories·Phase 3·NCT00522041·248 enrolled
Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures
Completed·VVentrus Biosciences, Inc·Phase 3·NCT01690221·434 enrolled
Application of Vitamin E on Anal Fissure
Completed·HHospital General Universitario Elche·Phase 3·NCT03787030·160 enrolled
Glyceryl Trinitrate Ointment vs Posterior Tibial Nerve Stimulation in the Treatment of Anal Fissure
Completed·HHospital General Universitario Elche·Phase 3·NCT02700438·80 enrolled
Pain and Bleeding in Subjects With Acute Anal Fissure: Comparative Evaluation of Three Treatments
Completed·UUniversity of Roma La Sapienza·Phase 4·NCT03355846·99 enrolled
Diltiazem Hydrochloride Cream for Anal Fissure
Completed·SS.L.A. Pharma AG·Phase 3·NCT01217515·465 enrolled
Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial
Completed·TTreviso Regional Hospital·Phase 4·NCT05616455·120 enrolled
Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial
Completed·—·Phase 4·NCT06859554·110 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)