VivoSeq
Oncology

Anatomic Stage IV Breast Cancer AJCC V8

9

Pipeline Programs↗

6

Active Trials↗

6

Companies Involved↗

Anatomic Stage IV Breast Cancer AJCC v8 is an early-stage landscape with 9 programs across 6 companies. The most active players are Avyxa, Gynecologic Oncology Group, Bristol-Myers Squibb. 2 therapies are approved.

Intelligence

Pipeline Metrics

Competitive Density

38/100

Pipeline Velocity

0/100

Mech. Concentration

25/100

Completion Rate

N/A

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

A

Avyxa

1 program

Phase 2G

Gynecologic Oncology Group

1 program

Phase 2Bristol-Myers Squibb logo

Bristol-Myers Squibb

1 program

Phase 2C

Celldex Therapeutics

1 program

Phase 2Gilead logo

Gilead

1 program

Phase 2AstraZeneca logo

AstraZeneca

3 programs

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

10programs
Small molecule440%
Monoclonal antibody330%
Antibody–drug conjugate220%
Vaccine110%

Modality classified for 100% of 10 pipeline programs.

Analysis

Trial Status

6

clinical trials

Recruiting5 · 83%
Active, not recruiting1 · 17%

Clinical Trials

Trial Activity

6 trials

Randomized Phase 2 Clinical Trial of Nab-Paclitaxel + Durvalumab (MEDI4736) + Tremelimumab + Neoantigen Vaccine vs. Nab-Paclitaxel + Durvalumab (MEDI4736) + Tremelimumab in Patients With Metastatic Triple Negative Breast Cancer
Recruiting·National Cancer Institute (NCI)·Phase 2·NCT03606967·86 enrolled
Pilot Study to Evaluate 64Cu-DOTA-Trastuzumab Imaging in Patients With HER2+ Breast Cancer With Brain Metastatsis Treated With Fam-Trastuzumab Deruxtecan
Recruiting·CCity of Hope Medical Center·Approved·NCT05376878·10 enrolled
A Phase III Randomized Clinical Trial of Proton Craniospinal Irradiation Versus Involved-Field Radiotherapy for Patients With Breast Cancer or Non-Small Cell Lung Cancer Leptomeningeal Metastasis (Radiate-LM)
Recruiting·NRG Oncology·Phase 3·NCT06500481·115 enrolled
Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases
Recruiting·NRG Oncology·Phase 3·NCT06500455·269 enrolled
Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer
Recruiting·CCity of Hope Medical Center·N/A·NCT07664579·160 enrolled
FDG PET to Assess Therapeutic Response in Patients With Bone-Dominant Metastatic Breast Cancer, FEATURE
Active, not recruiting·ECOG-ACRIN Cancer Research Group·Phase 2·NCT04316117·138 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)