Stromectol

(Ivermectin)

ApprovedSmall molecule

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Ivermectin is used to treat parasitic infections caused by certain worms and lice, both in humans and animals. It works by paralyzing and killing the parasites so your body can eliminate them.[2] Stromectol is currently approved and in use across 25 indications[4].[1]

Stromectol is one of 315 small molecule programs targeting Loiasis. It is currently in Approved.

Indications

141

Total Trials

Active Trials

314

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

LoiasisCompleted

Dengue Hemorrhagic FeverApproved

LeishmaniasisApproved

OnchocerciasisCompleted

Atopic EczemaApproved

AnosmiaApproved

RosaceaCompleted

AcneApproved

Ocular OnchocerciasisApproved

HelminthiasisActive, not recruiting

LoiasisApproved

Completed

Dengue Hemorrhagic FeverApproved

Approved

LeishmaniasisApproved

Approved

OnchocerciasisApproved

Completed

Atopic EczemaApproved

Approved

AnosmiaApproved

Approved

RosaceaPhase 3

Completed

AcneApproved

Approved

Ocular OnchocerciasisApproved

Approved

HelminthiasisApproved

Active, not recruiting

Showing 10 of 25 indications

Competition

Competitive Landscape

332 competitors in Treatment

#DrugCompanyPhaseTrials

Stromectol

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Approved

10 2

Dexilant

Takeda

Preclinical

2 3

Niclocide

Bayer

Preclinical

1 4

Alfenta

Jazz Pharmaceuticals

Preclinical

1 5

Hivid

CConrado Roberto Hoffmann Filho

Preclinical

6 6

Valium

Akero Therapeutics

Preclinical

2 7

Barhemsys

Tibotec Pharmaceuticals, Ireland

Preclinical

1 8

Norpramin

VValidus Pharmaceuticals

Preclinical

1 9

Lotemax

PPharmos

Preclinical

1 10

Clomid

Ferring

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

ApprovedNot yet recruiting

Survival

NCT07657143

Phase 2Active, not recruiting

Scabies; Itch

NCT05500326

Q1 2027

Phase 2Recruiting

COVID-19

NCT05041907

Phase 3Not yet recruiting

Ascariasis

NCT07873398

Q2 2027

Phase 1Not yet recruiting

Cutaneous Warts

NCT07396714

Q3 2027

Phase 1Active, not recruiting

Rosacea

NCT04108897

Clinical

Trials by Indication[1]

COVID-1955 trials

Prophylaxis of COVID-19 Disease With Ivermectin in COVID-19 Contact Persons [German: Prophylaxe Der COVID-19-Erkrankung Mit Ivermectin Bei COVID-19 Kontaktpersonen]

Unknown status·IInfectopharm Arzneimittel GmbH·Phase 3·NCT05060666·412 enrolled

Ivermectin Versus Standard Treatment in Mild COVID-19

Unknown status·—·Phase 3·NCT04937569·1,644 enrolled

Role of Ivermectin and Colchicine in Treatment of COVID-19: Randomized Controlled Clinical Trial

Completed·—·N/A·NCT05930002·120 enrolled

Show 52 more trials

Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC)

Completed·MMinistry of Public Health, Argentina·Phase 2/3·NCT04894721·172 enrolled

Ivermectin as a Novel Therapy in COVID-19 Treatment

Completed·TTanta University·Phase 2/3·NCT04403555·164 enrolled

Randomized Phase IIA Clinical Trial to Evaluate the Efficacy of Ivermectin to Obtain Negative PCR Results in Patients With Early Phase COVID-19

Completed·UUniversidad Peruana Cayetano Heredia·Phase 2·NCT04635943·186 enrolled

Comparative Therapeutic Efficacy and Safety of Different Antiviral and Anti Inflammatory Drugs in COVID-19 Patients.

Unknown status·OOctober 6 University·Phase 4·NCT04779047·150 enrolled

Ivermectin Reproposing for Mild Stage COVID-19 Outpatients

Completed·MMinistry of Public Health, Argentina·Phase 1/2·NCT04784481·254 enrolled

Ivermectin for Post Exposure Prophylaxis of Covid-19

Terminated·—·Phase 3·NCT05231603·50 enrolled

Comparative Study of Hydroxychloroquine and Ivermectin in COVID-19 Prophylaxis

Unknown status·NNucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara·N/A·NCT04384458·400 enrolled

The Efficacy of Ivermectin in Larger Doses in COVID-19 Treatment

Recruiting·TTanta University·Phase 2/3·NCT04351347·300 enrolled

Evaluation of the Impact of the Administration of Single Dose of Ivermectin in the Early Phase of COVID-19

Unknown status·—·Phase 3·NCT05040724·200 enrolled

COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)

Completed·UUniversity of Minnesota·Phase 3·NCT04510194·1,323 enrolled

COVidIVERmectin: Ivermectin for Treatment of Covid-19

Terminated·IIRCCS Sacro Cuore Don Calabria di Negrar·Phase 2·NCT04438850·93 enrolled

The Zambia Ivermectin Trial for the Treatment and Prevention of COVID-19

Withdrawn·CCentre for Infectious Disease Research in Zambia·Phase 4·NCT04891250

Exploratory Ph I Trial of the Active IMP in Healthy Volunteers in Relation to COVID-19

Completed·MMedinCell S.A·Phase 1·NCT04632706·24 enrolled

Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)

Recruiting·UUniversity of Oxford·Phase 2·NCT05041907·3,800 enrolled

Sars-CoV-2/COVID-19 Ivermectin Navarra-ISGlobal Trial

Completed·—·Phase 2·NCT04390022·24 enrolled

Ivermectin to Prevent Hospitalizations in COVID-19

Completed·IInstituto de Cardiología de Corrientes·Phase 2/3·NCT04529525·501 enrolled

Early Treatment With Ivermectin and LosarTAN for Cancer Patients With COVID-19 Infection

Terminated·IInstituto do Cancer do Estado de São Paulo·Phase 2·NCT04447235·77 enrolled

Montelukast - a Treatment Choice for COVID-19

Completed·UUniversity of Sargodha··NCT04714515·150 enrolled

Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19

Unknown status·PPatrick Robinson··NCT05045937·1,000 enrolled

Novel Agents for Treatment of High-risk COVID-19 Positive Patients

Terminated·SSusanne Arnold·Phase 2·NCT04374019·13 enrolled

Remdesivir- Ivermectin Combination Therapy in Severe Covid-19

Unknown status·—·Phase 4·NCT04944082·60 enrolled

Efficacy of Ivermectin in COVID-19

Completed·—·Phase 1/2·NCT05076253·72 enrolled

Ivermectin in Treatment of COVID-19

Unknown status·ZZagazig University·Phase 2/3·NCT04445311·100 enrolled

ACTIV-6: COVID-19 Study of Repurposed Medications

Completed·—·Phase 3·NCT04885530·10,956 enrolled

Worldwide Trends on COVID-19 Research After the Declaration of COVID-19 Pandemic

Unknown status·QQassim University··NCT04460547·200 enrolled

Ivermectin to Prevent SARS-CoV-2 (COVID-19) Hospitalisation in Subjects Over 50

Terminated·IInsud Pharma·Phase 3·NCT05993143·249 enrolled

Prophylactic Ivermectin in COVID-19 Contacts

Completed·ZZagazig University·Phase 2/3·NCT04422561·340 enrolled

Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management

Completed·UUniversity of Baghdad·Phase 1·NCT04343092·16 enrolled

A Study to Evaluate the Efficacy and Safety of Ivermectin in COVID-19 Prevention

Completed·MMedinCell S.A·Phase 2·NCT05305560·400 enrolled

Ivermectin Nasal Drops in Post COVID-19 Parosmia

Unknown status·MMenoufia University·Phase 2·NCT05269030·60 enrolled

Efficacy of Ivermectin in Adult Patients With Early Stages of COVID-19 (EPIC Trial)

Completed·CCentro de Estudios en Infectogía Pediatrica·Phase 2/3·NCT04405843·476 enrolled

Study in COvid-19 Patients With iveRmectin (CORVETTE-01)

Unknown status·KKitasato University·Phase 2·NCT04703205·214 enrolled

Ivermectin Nasal Spray for COVID19 Patients

Unknown status·TTanta University·Phase 2·NCT04510233·60 enrolled

Ivermectin With Favipiravir in Mild-to-moderate COVID-19 Patients

Unknown status·MMahidol University·Phase 2·NCT05155527·200 enrolled

Efficacy of Ivermectin in Outpatients With Non-severe COVID-19

Unknown status·UUniversidad Nacional de Asunción·Phase 3·NCT04834115·400 enrolled

Efficacy of Ivermectin in COVID-19

Unknown status·—·N/A·NCT04392713·100 enrolled

Efficacy of Subcutaneous Ivermectin With or Without Zinc in COVID-19 Patients

Unknown status·SSohaib Ashraf·Phase 1/2·NCT04472585·180 enrolled

An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization

Unknown status·UUnknown Sponsor·Phase 4·NCT04729140·150 enrolled

Inhaled Ivermectin and COVID-19

Unknown status·MMansoura University·Phase 3·NCT04681053·80 enrolled

Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19

Unknown status·SSheba Medical Center·N/A·NCT04429711·100 enrolled

Ivermectin Role in Covid-19 Clinical Trial

Completed·—·Phase 4·NCT04746365·300 enrolled

A Study to Compare the Efficacy and Safety of Different Doses of Ivermectin for COVID-19

Terminated·—·Phase 2·NCT04431466·32 enrolled

Trial of Combination Therapy to Treat COVID-19 Infection

Completed·PProgenaBiome·Phase 1·NCT04482686·31 enrolled

Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients

Completed·FFMH College of Medicine and Dentistry·Phase 4·NCT04739410·50 enrolled

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm D (Ivermectin 600)

Completed·—·Phase 3·NCT05894538·1,459 enrolled

Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic

Completed·—·N/A·NCT04668469·600 enrolled

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm A (Ivermectin 400)

Completed·—·Phase 3·NCT05736861·1,800 enrolled

Ivermectin in Adults With Severe COVID-19.

Terminated·—·Phase 2·NCT04602507·75 enrolled

Ivermectin-Azithromycin-Cholecalciferol (IvAzCol) Combination Therapy for COVID-19

Completed·IInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado·N/A·NCT04399746·30 enrolled

Effectiveness and Safety of Ivermectin for the Prevention of Covid-19 Infection in Colombian Health Personnel

Unknown status·JJaveriana University·Phase 3·NCT04527211·550 enrolled

Ivermectin for Severe COVID-19 Management

Completed·—·Phase 3·NCT04646109·66 enrolled

Hydroxychloroquine and Ivermectin for the Treatment of COVID-19 Infection

Completed·—·Phase 3·NCT04391127·108 enrolled

Treatment10 trials

Treatment of Strongyloides Infection

Terminated·—·Phase 3·NCT03605758·51 enrolled

Comparison of Oral Ivermectin and Permethrin 5% Lotion in Treatment of Pediculosis Capitis

Completed·—·Phase 1·NCT05643820·60 enrolled

Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT03236168·118 enrolled

Show 7 more trials

Ivermectin In Treatment of COVID 19 Patients

Unknown status·MMinistry of Health and Population, Egypt·N/A·NCT04425707·100 enrolled

Ivermectin in the Treatment of Head Lice

Completed·JJohnson & Johnson Consumer and Personal Products Worldwide·Phase 3·NCT00819520·812 enrolled

Ivermectin Repurposed for the Treatment of PKDL

Completed·IInternational Centre for Diarrhoeal Disease Research, Bangladesh·Phase 1·NCT07286604·10 enrolled

Treatment of Pediculosis (Head Lice) in Senegal

Completed·IInstitut de Recherche pour le Developpement·N/A·NCT03578679·450 enrolled

Repurposing Ivermectin for PKDL Treatment

Completed·IInternational Centre for Diarrhoeal Disease Research, Bangladesh·Phase 1·NCT06251739·30 enrolled

Comparative Study Between Topical Permethrin 5% and Oral Ivermectin for the Treatment of Scabies

Completed·—·Phase 1·NCT05362513·100 enrolled

Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies

Not yet recruiting·—·Phase 2·NCT06896929·90 enrolled

Onchocerciasis8 trials

Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases

Recruiting·KKirby Institute·Phase 4·NCT07145736·52,000 enrolled

Emodepside Phase II Trial for Treatment of Onchocerciasis

Active, not recruiting·DDrugs for Neglected Diseases·Phase 2·NCT05180461·578 enrolled

Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole

Completed·MMedicines Development for Global Health·Phase 3·NCT04311671·12,979 enrolled

Show 5 more trials

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy

Completed·RRobert Colebunders·Phase 4·NCT03052998·91 enrolled

Ivermectin Treatment of Persons With Onchocerciasis-associated Epilepsy

Completed·UUniversiteit Antwerpen·Phase 4·NCT03852303·197 enrolled

Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Onchocerciasis

Active, not recruiting·MMedicines Development for Global Health·Phase 3·NCT03876262·323 enrolled

IVM Alone vs ALB + IVM Against Onchocerciasis

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 3·NCT03238131·272 enrolled

A Community Mapping and Participatory Research Protocol for Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations Through Social and Occupational Networks in Nigeria: MISSION Nigeria

Recruiting·UUwemedimo Friday Ekpo·Preclinical·NCT07707817·5,760 enrolled

Malaria7 trials

Repeat Ivermectin Mass Drug Administrations for MALaria Control II

Completed·BBrian Foy·Phase 3·NCT03967054·4,124 enrolled

Ivermectin-artemisinin Combination Therapy for Eradication of Malaria

Unknown status·MMakerere University·Phase 4·NCT05605925·138 enrolled

Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study

Completed·—·Phase 2/3·NCT02509481·2,712 enrolled

Show 4 more trials

Adjunctive Ivermectin Mass Drug Administration for Malaria Control

Unknown status·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT04844905·24,000 enrolled

Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study

Completed·LLiverpool School of Tropical Medicine·Phase 2·NCT02511353·141 enrolled

Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA)

Completed·BBarcelona Institute for Global Health·Phase 3·NCT04966702·48,145 enrolled

Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT03576313·4,939 enrolled

Rosacea4 trials

Rosacea and Ivermectin

Completed·WWake Forest University Health Sciences·Phase 2·NCT04275999·30 enrolled

Comparative Safety and Efficacy of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea

Completed·PPadagis LLC·Phase 3·NCT02795117·486 enrolled

Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.

Completed·UUniversity of California, San Diego·Phase 1/2·NCT02806414·25 enrolled

Show 1 more trial

Analysis of the Microbiome in Rosacea

Active, not recruiting·JJohns Hopkins University·Phase 1·NCT04108897·150 enrolled

43 more indications

Efficacy and Safety3 trials

Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration

Completed·JJennifer Keiser·Phase 2/3·NCT04700423·536 enrolled

Efficacy and Safety of MOX/ALB Co-administration

Completed·JJennifer Keiser·Phase 3·NCT04726969·255 enrolled

Efficacy and Safety of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis

Completed·JJennifer Keiser·Phase 3·NCT04848688·332 enrolled

Loiasis2 trials

Loiasis Cross-reactive Antigenemia and Treatment-related Adverse Events

Completed·WWashington University School of Medicine·Phase 4·NCT05085665·41 enrolled

Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT01593722·155 enrolled

Strongyloidiasis2 trials

Ivermectin Versus Albendazole for Chronic Strongyloidiasis

Completed·MMahidol University·Phase 3·NCT00765024·90 enrolled

Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis

Completed·CCentro per le Malattie Tropicali·Phase 3·NCT01570504·312 enrolled

Lymphatic Filariasis2 trials

Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis

Withdrawn·EEmory University·Phase 4·NCT01903057

Lymphatic Filariasis (LF) in Ivory Coast

Completed·UUniversity Hospitals Cleveland Medical Center·N/A·NCT02974049·189 enrolled

Safety and Efficacy2 trials

Safety and Efficacy of Drug Combinations Against Trichuris Trichiura

Completed·DDBL -Institute for Health Research and Development·N/A·NCT01050452·750 enrolled

Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects

Completed·TTopaz Pharmaceuticals Inc·Phase 2·NCT00994422·264 enrolled

Scabies2 trials

Veron Scabies Education and Eradication Program

Completed·—·N/A·NCT00604084·1,057 enrolled

Ivermectin/ Permethrin for Scabies

Completed·UUniversitas Padjadjaran·Phase 4·NCT05819983·60 enrolled

Efficacy2 trials

Efficacy, Safety, and PK of Ascending Dosages of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis

Completed·JJennifer Keiser·Phase 2/3·NCT04056325·617 enrolled

Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT02841215·133 enrolled

Children2 trials

Ivermectin Safety in Small Children

Completed·UUniversity of Oxford·Phase 2·NCT04332068·240 enrolled

Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children and Adults

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT02407782·1,092 enrolled

Survival2 trials

Effect of Ivermectin Metabolites on Mosquito Survival

Completed·UUniversity of Oxford·Phase 4·NCT03690453·20 enrolled

Evaluation of the Impact of Oral Ivermectin (150 Micrograms/kg) on Musca Sorbens, the Putative Vector of Trachoma

Not yet recruiting·LLondon School of Hygiene and Tropical Medicine·Approved·NCT07657143·12 enrolled

Pneumonia1 trial

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting·UUMC Utrecht·Phase 3·NCT02735707·20,000 enrolled

Viral Infection1 trial

Oral Ivermectin for Chikungunya Viral Infection

Completed·PPrince of Songkla University·Phase 3·NCT06259383·120 enrolled

SARS-CoV-21 trial

Efficacy, Safety and Tolerability of Ivermectin in Subjects Infected With SARS-CoV-2 With or Without Symptoms

Completed·IInvestigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V.·Phase 2·NCT04407507·66 enrolled

Severe Acute Respiratory Syndrome1 trial

Prevention and Treatment for COVID -19 (Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2) Associated Severe Pneumonia in the Gambia

Unknown status·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT04703608·1,200 enrolled

Pediatric Patients1 trial

Albendazole Plus High Dose Ivermectin for Trichuriasis in Pediatric Patients

Completed·AAlejandro Krolewiecki·Phase 2·NCT04041453·176 enrolled

Adverse Effect1 trial

Adverse Effects of Ivermectin Used in Egypt During COVID-19

Unknown status·MMenoufia University··NCT04747678·200 enrolled

Infection1 trial

Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection

Completed·MMedicines Development for Global Health·Phase 3·NCT00790998·1,497 enrolled

Immunity1 trial

Ivermectin and Human Immunity

Completed·UUniversity of Georgia·Phase 1·NCT03459794·12 enrolled

Cutaneous Warts1 trial

the Efficacy of Ivermectin Alone or With Microneedling in Treatment of Cutaneous Warts.

Not yet recruiting·—·Phase 1·NCT07396714·88 enrolled

Acute Lymphoblastic Leukemia1 trial

Physiologically-based Pharmacokinetic Modeling of Ivermectin in Healthy Human Volunteers

Completed·UUniversity Hospital, Basel, Switzerland·Phase 1·NCT02963324·12 enrolled

Skin Disease1 trial

Azithromycin - Ivermectin Mass Drug Administration for Skin Disease

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 4·NCT02775617·1,291 enrolled

Clinical Trial1 trial

Clinical Trial to "Study the Efficacy and Therapeutic Safety of Ivermectin: (SAINTBO)

Unknown status·—·Phase 2·NCT04836299·90 enrolled

Azithromycin1 trial

PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )

Completed·LLihir Medical Centre·Phase 2·NCT03664063·42 enrolled

Drug Therapy1 trial

Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 2·NCT01975441·182 enrolled

Pilot Study1 trial

Max Ivermectin- COVID 19 Study Versus Standard of Care Treatment for COVID 19 Cases. A Pilot Study

Unknown status·MMax Healthcare Insititute Limited·N/A·NCT04373824·50 enrolled

Pediatric1 trial

Pharmacokinetics and Pharmacodynamics of Ivermectin in Pediatric Dengue Patients

Completed·MMahidol University·Phase 2·NCT03432442·24 enrolled

CLE1 trial

Effect of Albendazole Dose on Clearance of Filarial Worms

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00339417·1,000 enrolled

Resistance1 trial

Insecticide Resistance Management in Burkina Faso and Côte D'Ivoire

Completed·IInstitut de Recherche pour le Developpement·Phase 3·NCT03074435·15,776 enrolled

Alcohol Use Disorders1 trial

Development of Ivermectin for Alcohol Use Disorders

Completed·UUniversity of California, Los Angeles·Phase 1/2·NCT02046200·11 enrolled

Acceptability1 trial

Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC

Completed·JJennifer Keiser·Phase 2·NCT06184399·260 enrolled

Lice Infestation1 trial

A Safety and Efficacy Study Comparing 0.5% Ivermectin Cream to a Vehicle Control in Subjects With Head Lice Infestation

Completed·TTopaz Pharmaceuticals Inc·Phase 3·NCT01066585·410 enrolled

Cohort Study1 trial

SARS-CoV-2 Pre-exposure Prophylaxis With Ivermectin Retrospective Cohort Study

Completed·GGrupo Rescue S.A.S República Dominicana··NCT04832945·713 enrolled

GAN1 trial

Co-administration of IVM and ALB in School-based Deworming in Uganda

Completed·JJennifer Keiser··NCT06497075·8,767 enrolled

Fasting Conditions1 trial

Bioequivalence Study to Compare Two Tablets of Ivermectin Tablets (3 mg Ivermectin) Versus Two Tablets of Stromectol ® Tablets (3 mg Ivermectin), in Healthy Subjects Under Fasting Conditions

Completed·HHumanis Saglık Anonim Sirketi·Phase 1·NCT05082753·50 enrolled

Effectiveness1 trial

Comparison Effectiveness of Oral Ivermectin , 1% Permethrin Shampoo and 4% Dimeticone Liquid Gel in the Treatment of Pediculosis Capitis Among School Children in Chachoengsao Province, Thailand

Active, not recruiting·PPhramongkutklao College of Medicine and Hospital·Phase 4·NCT06332872·117 enrolled

TED1 trial

Ivermectin Solution Bioequivalence Study - Fasted

Completed·JJohnson & Johnson Consumer and Personal Products Worldwide·Phase 1·NCT00921154·24 enrolled

Genital Warts1 trial

Efficacy And Safety Of Oral Ivermectin For The Treatment Of Genital Warts

Not yet recruiting·UUniversity of Health Sciences Lahore·Preclinical·NCT07913321·90 enrolled

Anatomic Stage IV Breast Cancer AJCC v81 trial

A Phase I/II Study Evaluating the Safety and Efficacy of Ivermectin in Combination With Immune Checkpoint Inhibitor in Patients With Metastatic Triple Negative Breast Cancer and HR+/HER2- Metastatic Breast Cancer

Recruiting·YYuan Yuan·Preclinical·NCT05318469·34 enrolled

Pancreatic Cancer1 trial

A Randomized, Open-Label Study of Standard of Care Prophylaxis Versus Standard of Care Prophylaxis Plus Ivermectin for the Prevention of Daraxonrasib-Induced Skin Toxicity in Patients With Metastatic Pancreatic Cancer

Recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT07895498·122 enrolled

Scabies; Itch1 trial

Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study)

Active, not recruiting·MMurdoch Childrens Research Institute·Phase 2·NCT05500326·120 enrolled

Ascariasis1 trial

Change in Soil-transmitted Helminth Infection Intensity Following Mass Drug Administration With Ivermectin Plus Albendazole or Albendazole Alone in Ugandan Schoolchildren: a Follow-up Study to Assess Potential Drug Resistance

Not yet recruiting·JJennifer Keiser·Phase 3·NCT07873398·450 enrolled

Warts1 trial

A Prospective Randomized Controlled Clinical Trial to Evaluate the Efficacy of Oral and Topical Ivermectin in the Treatment of Plane Warts

Completed·AAl-Azhar University·Phase 2·NCT07710638·80 enrolled

The Focus of the Study is to Assess the Effectiveness of Topical Ivermectin on Eliminating Eyelash Sleeves1 trial

Treatment of Ocular Demodex Infestation With Topical Ivermectin Cream 1%

Completed·HHelm Vision Group·Phase 3·NCT05213585·20 enrolled

Unspecified5 trials

Ivermectin Solution Bioequivalence Study - With Food

Completed·JJohnson & Johnson Consumer and Personal Products Worldwide·Phase 1·NCT00921674·24 enrolled

Moxidectin for LF, Cote d'Ivoire (DOLF)

Completed·WWashington University School of Medicine·Phase 3·NCT04410406·164 enrolled

Ivermectin Solution Bioequivalence Study - With Food (Repeat)

Completed·JJohnson & Johnson Consumer and Personal Products Worldwide·Phase 1·NCT00921219·34 enrolled

Show 2 more trials

Bioequivalence Study of Ivermectin 1% Cream and Soolantra (Ivermectin) 10 mg/g Cream

Completed·HHumanis Saglık Anonim Sirketi·Phase 1·NCT06557603·44 enrolled

Ivermectina Colombia (IVERCOL)

Unknown status·AAyudas Diagnosticas Sura S.A.S·Phase 2/3·NCT04886362·966 enrolled

Regulatory

FDA Approval Timeline[5]

Nov 22, 1996

STROMECTOL

NDA NDA050742

Oct 8, 1998

STROMECTOL

NDA NDA050742

Aug 4, 1999

STROMECTOL

NDA NDA050742

Nov 10, 1999

STROMECTOL

NDA NDA050742

Jan 4, 2001

STROMECTOL

NDA NDA050742

Jan 4, 2001

STROMECTOL

NDA NDA050742

Jul 17, 2001

STROMECTOL

NDA NDA050742

May 28, 2002

STROMECTOL

NDA NDA050742

Dec 12, 2002

STROMECTOL

NDA NDA050742

Jan 15, 2003

STROMECTOL

NDA NDA050742

Feb 12, 2004

STROMECTOL

NDA NDA050742

Feb 12, 2004

STROMECTOL

NDA NDA050742

Nov 18, 2004

STROMECTOL

NDA NDA050742

Jan 20, 2006

STROMECTOL

NDA NDA050742

Jan 20, 2006

STROMECTOL

NDA NDA050742

Sep 26, 2007

STROMECTOL

NDA NDA050742

Sep 26, 2007

STROMECTOL

NDA NDA050742

Feb 26, 2008

STROMECTOL

NDA NDA050742

Sep 12, 2008

STROMECTOL

NDA NDA050742

May 1, 2009

STROMECTOL

NDA NDA050742

Jun 11, 2009

STROMECTOL

NDA NDA050742

Jun 11, 2009

STROMECTOL

NDA NDA050742

Dec 15, 2009

STROMECTOL

NDA NDA050742

Feb 7, 2012

SKLICE

NDA NDA202736

Dec 19, 2014

SOOLANTRA

NDA NDA206255

Apr 7, 2015

STROMECTOL

NDA NDA050742

May 11, 2015

STROMECTOL

NDA NDA050742

Mar 14, 2022

STROMECTOL

NDA NDA050742

Sources

References

[1]
ClinicalTrials.gov — 141 trial records for Ivermectin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Stromectol drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Ivermectin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Ivermectin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA050742). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Stromectol. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glutamate-Gated Chloride Channel Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Patent Landscape[6]

Patent Cliff

Mar 13, 2034

Earliest patent expiration — generic entry possible after this date

Patent #Expires

9233118Mar 13, 2034

9089587Mar 13, 2034

9233117Mar 13, 2034

9782425Mar 13, 2034

10206939Mar 13, 2034

Stromectol

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Q3 2027

Trials by Indication[1]

COVID-1955 trials

Treatment10 trials

Onchocerciasis8 trials

Malaria7 trials

Rosacea4 trials

Efficacy and Safety3 trials

Loiasis2 trials

Strongyloidiasis2 trials

Lymphatic Filariasis2 trials

Safety and Efficacy2 trials

Scabies2 trials

Efficacy2 trials

Children2 trials

Survival2 trials

Pneumonia1 trial

Viral Infection1 trial

SARS-CoV-21 trial

Severe Acute Respiratory Syndrome1 trial

Pediatric Patients1 trial

Adverse Effect1 trial

Infection1 trial

Immunity1 trial

Cutaneous Warts1 trial

Acute Lymphoblastic Leukemia1 trial

Skin Disease1 trial

Clinical Trial1 trial

Azithromycin1 trial

Drug Therapy1 trial

Pilot Study1 trial

Pediatric1 trial

CLE1 trial

Resistance1 trial

Alcohol Use Disorders1 trial

Acceptability1 trial

Lice Infestation1 trial

Cohort Study1 trial

GAN1 trial

Fasting Conditions1 trial

Effectiveness1 trial

TED1 trial

Genital Warts1 trial

Anatomic Stage IV Breast Cancer AJCC v81 trial

Pancreatic Cancer1 trial

Scabies; Itch1 trial

Ascariasis1 trial

Warts1 trial

The Focus of the Study is to Assess the Effectiveness of Topical Ivermectin on Eliminating Eyelash Sleeves1 trial

Unspecified5 trials

FDA Approval Timeline[5]

References

Drug Info

Quick Facts

Patent Landscape[6]

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