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Hematology/Anemia

Anemia

131

Pipeline Programs↗

150

Active Trials↗

84

Companies Involved↗

Anemia is a highly competitive landscape with 131 programs across 84 companies. The most active players are Shenyang Sunshine Pharmaceutical Co., LTD., Shenzhen Salubris Pharmaceuticals Co., Ltd., Novartis. 26 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

80/100

Pipeline Velocity

72/100

Mech. Concentration

11/100

Completion Rate

80/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Shenyang Sunshine Pharmaceutical Co., LTD.

2 programs

Shenzhen Salubris Pharmaceuticals Co., Ltd.

1 program

Novartis

1 program

Ryvu Therapeutics SA

1 program

Kind Pharmaceuticals LLC

1 program

Pipeline

Programs by Phase

Preclinical60

Prednisolone Acetate

Novartis

Siltuximab

RECORDATI GROUP

Dapagliflozin

AstraZeneca

Pyridoxine

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Methylprednisolone Sodium Succinate

Massachusetts Eye and Ear Infirmary

Phase 110

DISC-0974

Disc Medicine, Inc

F182112 Single-Agent

Institute of Hematology & Blood Diseases Hospital, China

OM336

Ouro Medicines

APR-2020

Apriligen, Inc.

Thiscart19a

Fundamenta Therapeutics, Ltd.

Phase 235

Spironolactone

Pfizer

Erythropoietin Stimulating Agent

Ain Shams University

Zoledronic Acid

Pfizer

Crizanlizumab

Novartis

IMR-687

Cardurion Pharmaceuticals, Inc.

Phase 326

Rituximab

Roche

BCD-131

Biocad

Ibrutinib

Pharmacyclics LLC.

Epoetin Alfa

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Alemtuzumab

Genzyme, a Sanofi Company

Approved

No programs

Analysis

Modality Breakdown

80%

Small molecule

89 of 111 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 111 classified programs, each share of the total. Modality classified for 98% of 131 pipeline programs.

Analysis

Trial Status

653

clinical trials

Completed345 · 53%

Unknown status69 · 11%

Terminated68 · 10%

Recruiting67 · 10%

Not yet recruiting46 · 7%

Active, not recruiting34 · 5%

Other24 · 4%

Clinical Trials

Trial Activity

653 trials

Construction of Abnormal Projection Regions of Cognitive Neural Networks in Patients With Anemia Using Functional Near-Infrared Spectroscopy (fNIRS)

Recruiting·IInstitute of Hematology & Blood Diseases Hospital, China·N/A·NCT07578675·323 enrolled

A Randomized Controlled Trial Comparing Different Graft Sources for Haploidentical Transplantation in Aplastic Anemia

Recruiting·PPeking University People's Hospital·Preclinical·NCT07629947·180 enrolled

Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History Study

Recruiting·National Cancer Institute (NCI)·N/A·NCT00027274·4,000 enrolled

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-Cells

Recruiting·National Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT01174108·120 enrolled

Haploidentical Donor Hematopoietic Cell Transplantation for Patients With Severe Aplastic Anemia

Recruiting·SSt. Jude Children's Research Hospital·Phase 2·NCT04558736·21 enrolled

RALLY-MF: A Phase 1b/2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of DISC-0974 in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

Recruiting·DDisc Medicine, Inc·Preclinical·NCT05320198·150 enrolled

Efficacy and Safety of Ferric Citrate in Iron Deficiency Anemia During the Second Trimester of Pregnancy in Bangladesh: A Randomized Controlled Trial

Recruiting·DDhaka Medical College·Phase 3·NCT07381426·680 enrolled

The Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

Recruiting·National Heart, Lung, and Blood Institute (NHLBI)·N/A·NCT05012111·1,000 enrolled

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant Outcome

Recruiting·National Heart, Lung, and Blood Institute (NHLBI)·Preclinical·NCT03173937·37 enrolled

Patient Blood Management in Cardiac Surgical Patients: the ICARUS-2 Study

Recruiting·FFondazione Policlinico Universitario Agostino Gemelli IRCCS·N/A·NCT06637137·464 enrolled

Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

Recruiting·National Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT03520647·56 enrolled

An Open-Label, Phase 1b, Multiple Ascending Dose Study of OM336 in Participants With Active Autoimmune Cytopenias

Recruiting·OOuro Medicines·Phase 1·NCT07083960·32 enrolled

A Prospective, Open-Label, Randomized, Interventional Study to Evaluate the Efficacy and Tolerability of Sucrosomial® Iron vs Ferric Maltol in Iron Deficient Women

Recruiting·PPharmanutra S.p.a.·Approved·NCT07308769·146 enrolled

Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia

Recruiting·National Cancer Institute (NCI)·N/A·NCT05687149·200 enrolled

The Experience and Management of Cancer Screening-Related Anxiety in Fanconi Anemia: an Ethnographic Study

Recruiting·National Cancer Institute (NCI)·N/A·NCT06744283·20 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)