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Vitamin B6

(Pyridoxine)

ApprovedSmall molecule

AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Pyridoxine is a form of vitamin B6 that helps your body break down proteins and make neurotransmitters (brain chemicals). It's used to treat or prevent vitamin B6 deficiency and can help with conditions like nerve pain, morning sickness, and certain types of anemia.[2] Vitamin B6 is currently approved and in use across 38 indications[4].[1]

Vitamin B6 is one of 761 small molecule programs targeting Compulsive behaviors. It is currently in Approved.

38

Indications

24

Total Trials

0

Active Trials

760

Competitors

Pipeline

Status by Indication[4][1]

Indication

Compulsive BehaviorsActive, not recruiting

Pyridoxine-Dependent EpilepsyActive, not recruiting

Atrial Heart Septal DefectActive, not recruiting

Non-Alcoholic Fatty Liver DiseaseActive, not recruiting

Attention Deficit Hyperactivity DisorderActive, not recruiting

StrokeActive, not recruiting

Autistic BehaviorActive, not recruiting

LymphomaActive, not recruiting

Alcoholic Fatty Liver DiseaseActive, not recruiting

Type 2 Diabetes MellitusUnknown

Compulsive BehaviorsPreclinical

Active, not recruiting

Pyridoxine-Dependent EpilepsyPreclinical

Active, not recruiting

Atrial Heart Septal DefectPreclinical

Active, not recruiting

Non-Alcoholic Fatty Liver DiseasePhase 3

Active, not recruiting

Attention Deficit Hyperactivity DisorderPhase 2

Active, not recruiting

StrokePhase 3

Active, not recruiting

Autistic BehaviorPreclinical

Active, not recruiting

LymphomaPhase 1/Phase 2

Active, not recruiting

Alcoholic Fatty Liver DiseasePhase 2

Active, not recruiting

Type 2 Diabetes MellitusPreclinical

Unknown

Showing 10 of 35 indications

Competition

Competitive Landscape

1774 competitors in Lymphoma

#DrugCompanyPhaseTrials

Vitamin B6

AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Blenoxane

SSequus Pharmaceuticals

Oncaspar

Zofran

Norvir

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Kenalog

BBausch Health Americas, Inc.

Systemic Therapy

Bristol-Myers Squibb

Decadron

QQuince Therapeutics S.p.A.

CAR-T

HHebei Senlang Biotechnology Inc., Ltd.

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Lymphoma3 trials

Belinostat Combined With Azacitidine/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Refractory or Relapsed Lymphoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT02701673

Aza-SAHA-GBM With AutoSCT for Refractory Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT01983969·61 enrolled

Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Lymphoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT02961816

Stroke1 trial

Vitamin Therapy for Prevention of Stroke

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 3·NCT00004734

Hand-foot syndrome1 trial

Study of Pyridoxine for Hand-Foot Syndrome

Completed·—·Phase 3·NCT00446147·389 enrolled

Stem Cell Transplant1 trial

Carfilzomib/SAHA Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant in Myeloma

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT02114502

Lactation1 trial

Lactation Inhibition, the Efficiency of Vitamin B6 Versus Cabergoline

Completed·HHaEmek Medical Center, Israel·N/A·NCT05024422·89 enrolled

17 more indications

Adverse Events1 trial

Effect of Pyridoxine on Behavioral Adverse Events of Levetiracetam

Completed·NNasim Tabrizi·Phase 4·NCT05008354·30 enrolled

OCD1 trial

Effect of Pyridoxine as Add-on Therapy in OCD Patients

Unknown status·—·N/A·NCT06244121·76 enrolled

Fatigue1 trial

Modafinil in Cancer Related Fatigue

Completed·IIndira Gandhi Medical College, Shimla·Phase 3·NCT01440621·217 enrolled

Movement Disorder1 trial

Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

Unknown status·NNucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara·Phase 2/3·NCT03790345·45 enrolled

Schizophrenia1 trial

Treatment of Acute Schizophrenia With Vitamin Therapy

Completed·—·Phase 4·NCT00140166·55 enrolled

Tardive Dyskinesia1 trial

Pyridoxal Kinase Activity in Tardive Dyskinesia

Withdrawn·—·Phase 3·NCT01908452

Adenocarcinoma1 trial

S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum

Withdrawn·SSWOG Cancer Research Network·Phase 2·NCT00070434

Diffuse Large B-Cell Lymphoma1 trial

Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC Subtype

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT02589145·8 enrolled

Epilepsy1 trial

Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients

Withdrawn·UUniversity of British Columbia··NCT01795170

HIV-Infected Individuals1 trial

Effect of Vitamin B on Plasma Neurofilament Light Protein (NFL) in HIV-infected Individuals With Increased Plasma Homocysteine

Unknown status·GGöteborg University·Phase 2·NCT02773147·60 enrolled

Randomized1 trial

Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012

Withdrawn·CCenters for Disease Control and Prevention·Phase 2·NCT01730313

End-Stage Renal Disease1 trial

Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis

Completed·GGeorgetown University·N/A·NCT00004495·84 enrolled

Tuberculosis1 trial

Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV

Terminated·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 2·NCT01601626·71 enrolled

Infantile Spasms1 trial

Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00004758·30 enrolled

Alcohol1 trial

Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT)

Completed·UUniversity of California, San Francisco·Phase 4·NCT03302299·302 enrolled

ST Elevation Myocardial Infarction1 trial

Short Course Low Dose Oral Colchicine After ST Elevation Myocardial Infarction(STEMI)

Unknown status·NNational University of Malaysia·Phase 4·NCT06020300·64 enrolled

Unspecified1 trial

Video Based Directly Observed Therapy for Latent TB

Withdrawn·SSt. Louis University··NCT03783728

Sources

References

[1]
ClinicalTrials.gov — 24 trial records for Pyridoxine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Vitamin B6 drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Pyridoxine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Pyridoxine. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

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