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Vitamin B6

(Pyridoxine)

PreclinicalSmall molecule

AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Pyridoxine is a form of vitamin B6 that helps your body break down proteins and make neurotransmitters (brain chemicals). It's used to treat or prevent vitamin B6 deficiency and can help with conditions like nerve pain, morning sickness, and certain types of anemia.[1] Vitamin B6 is currently being investigated across 13 indications[3], with its most advanced program in Preclinical.[1]

Vitamin B6 is one of 310 small molecule programs targeting Compulsive behaviors. It is currently in Preclinical.

13

Indications

24

Total Trials

0

Active Trials

309

Competitors

Pipeline

Status by Indication[3][1]

Indication

Compulsive BehaviorsActive, not recruiting

Inflammatory Bowel DiseaseActive, not recruiting

OsteoporosisUnknown

Pyridoxine-Dependent EpilepsyActive, not recruiting

Osteochondritis DissecansActive, not recruiting

Atrial Heart Septal DefectActive, not recruiting

Obsessive-Compulsive DisorderActive, not recruiting

Autistic BehaviorActive, not recruiting

Chronic Kidney DiseaseUnknown

Type 2 Diabetes MellitusUnknown

Compulsive BehaviorsPreclinical

Active, not recruiting

Inflammatory Bowel DiseasePreclinical

Active, not recruiting

OsteoporosisPreclinical

Unknown

Pyridoxine-Dependent EpilepsyPreclinical

Active, not recruiting

Osteochondritis DissecansPreclinical

Active, not recruiting

Atrial Heart Septal DefectPreclinical

Active, not recruiting

Obsessive-Compulsive DisorderPreclinical

Active, not recruiting

Autistic BehaviorPreclinical

Active, not recruiting

Chronic Kidney DiseasePreclinical

Unknown

Type 2 Diabetes MellitusPreclinical

Unknown

Showing 10 of 13 indications

Competition

Competitive Landscape

172 competitors in Chronic Kidney Disease

#DrugCompanyPhaseTrials

Vitamin B6

AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Uloric

Lorelco

Sovaldi

Glucotrol

Vemlidy

Activase

Flomax

Verquvo

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

PROCRIT

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Lymphoma3 trials

Belinostat Combined With Azacitidine/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Refractory or Relapsed Lymphoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT02701673

Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Lymphoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT02961816

Aza-SAHA-GBM With AutoSCT for Refractory Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT01983969·61 enrolled

Schizophrenia1 trial

Treatment of Acute Schizophrenia With Vitamin Therapy

Completed·—·Phase 4·NCT00140166·55 enrolled

Diffuse Large B-Cell Lymphoma1 trial

Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC Subtype

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT02589145·8 enrolled

ST Elevation Myocardial Infarction1 trial

Short Course Low Dose Oral Colchicine After ST Elevation Myocardial Infarction(STEMI)

Unknown status·NNational University of Malaysia·Phase 4·NCT06020300·64 enrolled

Alcohol1 trial

Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT)

Completed·UUniversity of California, San Francisco·Phase 4·NCT03302299·302 enrolled

17 more indications

Movement Disorder1 trial

Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

Unknown status·NNucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara·Phase 2/3·NCT03790345·45 enrolled

Tuberculosis1 trial

Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV

Terminated·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 2·NCT01601626·71 enrolled

Infantile Spasms1 trial

Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00004758·30 enrolled

Fatigue1 trial

Modafinil in Cancer Related Fatigue

Completed·IIndira Gandhi Medical College, Shimla·Phase 3·NCT01440621·217 enrolled

Hand-foot syndrome1 trial

Study of Pyridoxine for Hand-Foot Syndrome

Completed·—·Phase 3·NCT00446147·389 enrolled

Stroke1 trial

Vitamin Therapy for Prevention of Stroke

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 3·NCT00004734

Lactation1 trial

Lactation Inhibition, the Efficiency of Vitamin B6 Versus Cabergoline

Completed·HHaEmek Medical Center, Israel·N/A·NCT05024422·89 enrolled

OCD1 trial

Effect of Pyridoxine as Add-on Therapy in OCD Patients

Unknown status·—·N/A·NCT06244121·76 enrolled

End-Stage Renal Disease1 trial

Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis

Completed·GGeorgetown University·N/A·NCT00004495·84 enrolled

Randomized1 trial

Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012

Withdrawn·CCenters for Disease Control and Prevention·Phase 2·NCT01730313

Epilepsy1 trial

Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients

Withdrawn·UUniversity of British Columbia··NCT01795170

HIV-Infected Individuals1 trial

Effect of Vitamin B on Plasma Neurofilament Light Protein (NFL) in HIV-infected Individuals With Increased Plasma Homocysteine

Unknown status·GGöteborg University·Phase 2·NCT02773147·60 enrolled

Tardive Dyskinesia1 trial

Pyridoxal Kinase Activity in Tardive Dyskinesia

Withdrawn·—·Phase 3·NCT01908452

Adenocarcinoma1 trial

S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum

Withdrawn·SSWOG Cancer Research Network·Phase 2·NCT00070434

Stem Cell Transplant1 trial

Carfilzomib/SAHA Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant in Myeloma

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT02114502

Adverse Events1 trial

Effect of Pyridoxine on Behavioral Adverse Events of Levetiracetam

Completed·NNasim Tabrizi·Phase 4·NCT05008354·30 enrolled

Unspecified1 trial

Video Based Directly Observed Therapy for Latent TB

Withdrawn·SSt. Louis University··NCT03783728

Sources

References

[1]
ClinicalTrials.gov — 24 trial records for Pyridoxine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Pyridoxine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Pyridoxine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

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