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Musculoskeletal/Anterior Cruciate Ligament Reconstruction

Musculoskeletal

Anterior Cruciate Ligament Reconstruction

3

Pipeline Programs↗

13

Active Trials↗

1

Companies Involved↗

Anterior Cruciate Ligament Reconstruction is an early-stage landscape with 3 programs across 1 company. 2 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

35/100

Pipeline Velocity

32/100

Mech. Concentration

100/100

Completion Rate

92/100

Attrition Rate

5/100

Pipeline

Programs by Phase

Preclinical

No programs

Phase 11

Montelukast

Organon and Co

Phase 2

No programs

Phase 32

Botulinum Toxin

Meshalkin Research Institute of Pathology of Circulation

Intraosseous Morphine

The Methodist Hospital Research Institute

Approved

No programs

Analysis

Trial Status

44

clinical trials

Completed24 · 55%

Recruiting7 · 16%

Not yet recruiting5 · 11%

Unknown status5 · 11%

Withdrawn1 · 2%

Active, not recruiting1 · 2%

Other1 · 2%

Clinical Trials

Trial Activity

44 trials

ACL Reconstruction Rehabilitation With Exercise and Psychological Support

Recruiting·HHealthPartners Institute·Preclinical·NCT06991192·60 enrolled

Comparison Between a Session of Walking Synchronized to Fractal- VS Isochronous-Based Cues on Gait Variability and Corticospinal Measures in Athletes With a Reconstructed Anterior Cruciate Ligament: A Crossover Randomized Controlled Trial

Recruiting·EEgas Moniz - Cooperativa de Ensino Superior, CRL·Preclinical·NCT07243535·36 enrolled

Effect of Pulsed Electromagnetic Fields on Promoting Hamstring Muscle Strength After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft: A Double-Blind, Placebo-Controlled, Randomised Clinical Trial

Recruiting·CChinese University of Hong Kong·Preclinical·NCT06464705·60 enrolled

A Prospective, Randomized Controlled Study Comparing Tourniquet Use Versus a Dual-flow Arthroscopy Sheath in Anterior Cruciate Ligament (ACL) Reconstruction Surgery.

Recruiting·CCentre Hospitalier Intercommunal de Toulon La Seyne sur Mer·Preclinical·NCT06819696·128 enrolled

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

Recruiting·—·Phase 1·NCT04572256·30 enrolled

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

Recruiting·TThe Methodist Hospital Research Institute·Phase 4·NCT06511232·84 enrolled

The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.

Recruiting·—·N/A·NCT06442319·60 enrolled

Cyclops Syndrome After Anterior Cruciate Ligament Reconstruction

Active, not recruiting·GGCS Ramsay Santé pour l'Enseignement et la Recherche·Phase 3·NCT05008731·132 enrolled

Effects of Dry Needling on Quadriceps Muscle Strength in Acute Post-Operative Anterior Cruciate Ligament Reconstruction With Quadriceps Autograft in the Pediatric Population

Not yet recruiting·CChildren's Mercy Hospital Kansas City·Preclinical·NCT07657195·40 enrolled

The Impact of Superimposed Vibration on the Recovery of Muscle Strength and Function Following Anterior Cruciate Ligament Surgery

Not yet recruiting·CCentre orthopédique de Dracy-le-Fort·Preclinical·NCT07555613·62 enrolled

The Effect of Lateral Extra-Articular Tenodesis on Lower-Extremity Lean Mass Recovery Following Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial

Not yet recruiting·UUniversity of Alabama at Birmingham·Preclinical·NCT07777458·40 enrolled

Oral Melatonin With Intra Articular Analgesia on Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction

Not yet recruiting·—·N/A·NCT07096635·50 enrolled

Study the Anti-inflammatory Effect of Tranexamic Acid When Used in Anterior Cruciate Ligament Reconstruction.

Not yet recruiting·CChirec·Phase 4·NCT07332910·60 enrolled

Immunometabolic Mechanisms of Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction

Completed·YYale University·Preclinical·NCT05012982·18 enrolled

Prospective Evaluation of Silk Fibroin Versus 2-Octyl Cyanoacrylate Incision Dressings Following ACL Reconstruction

Completed·NNYU Langone Health·Preclinical·NCT07217613·100 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)