Botulinum Toxin

Phase 3Small molecule

MMeshalkin Research Institute of Pathology of Circulation

Botulinum Toxin is one of 229 small molecule programs targeting Botulinum Toxin. It is currently in Phase 3.

Indications

Total Trials

Active Trials

228

Competitors

Pipeline

Status by Indication[3][1]

Indication

Botulinum ToxinUnknown status

Cervical DystoniaActive, not recruiting

StrokeActive, not recruiting

DystoniaActive, not recruiting

Hidradenitis SuppurativaActive, not recruiting

Spastic Cerebral PalsyActive, not recruiting

Focal DystoniaActive, not recruiting

TreatmentCompleted

ClubfootUnknown status

BotoxUnknown status

Botulinum ToxinPhase 3

Unknown status

Cervical DystoniaPreclinical

Active, not recruiting

StrokePreclinical

Active, not recruiting

DystoniaPreclinical

Active, not recruiting

Hidradenitis SuppurativaPreclinical

Active, not recruiting

Spastic Cerebral PalsyPreclinical

Active, not recruiting

Focal DystoniaPreclinical

Active, not recruiting

TreatmentPreclinical

Completed

ClubfootPreclinical

Unknown status

BotoxPhase 3

Unknown status

Showing 10 of 16 indications

Competition

Competitive Landscape

350 competitors in Treatment

#DrugCompanyPhaseTrials

Botulinum Toxin

MMeshalkin Research Institute of Pathology of Circulation

Phase 3

2 2

Dexilant

Takeda

Preclinical

2 3

Alfenta

Jazz Pharmaceuticals

Preclinical

1 4

Niclocide

Bayer

Preclinical

1 5

Hivid

CConrado Roberto Hoffmann Filho

Preclinical

6 6

Valium

Akero Therapeutics

Preclinical

2 7

Lotemax

PPharmos

Preclinical

1 8

Norpramin

VValidus Pharmaceuticals

Preclinical

1 9

Barhemsys

Tibotec Pharmaceuticals, Ireland

Preclinical

1 10

Clomid

Ferring

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalRecruiting

Head and Neck

NCT07082972

Phase 2/3Active, not recruiting

Randomized Controlled Trial

NCT05478551

Q1 2027

ApprovedActive, not recruiting

Tremor

NCT06411028

Phase 3Not yet recruiting

Botulinum Toxin

NCT07013240

N/ARecruiting

Botulinum Toxin

NCT04220931

N/ARecruiting

Stroke

NCT05874154

Clinical

Trials by Indication[1]

Botulinum Toxin12 trials

Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A

Completed·LLoyola University·Phase 3·NCT01586819·26 enrolled

Infiltrations of OnaBotulinum Toxin A in Resistant Depression: Comparison of Two Facial Injection Sites.

Unknown status·—·N/A·NCT03484754·58 enrolled

Effect of Topical Botulinum Toxin Eyedrop on Palpebral Fissure

Terminated·UUniversity of Miami·Phase 4·NCT06080438·2 enrolled

Show 9 more trials

Botulinum Toxin Effects on Plantar Ulcer Recurrence

Completed·WWashington University School of Medicine·N/A·NCT00845897·17 enrolled

Botulinum Toxin Injection for Treatment of Vaginismus

Unknown status·TTehran University of Medical Sciences·Phase 3·NCT00638066·40 enrolled

Botulinum Toxin is a Potential Prophylactic Therapy for Minimizing Post-excisional Scarring (Allergan Botox Scar Study)

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT02623829·42 enrolled

Botulinum Toxin to Improve Lower Blepharoplasty Scar

Unknown status·—·Phase 4·NCT02786550·40 enrolled

Partial Blocks of Rectus Femoris and Soleus With Botulinum Toxin Type A (Xeomin®) to Improve Gait in Hemiparesis

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 2·NCT03119948·66 enrolled

Efficacy of One or Two Botulinum Toxin Injections in the Treatment of Chronic Lateral Epicondylalgia: a Retrospective Study (EPITOX)

Active, not recruiting·UUniversity Hospital, Brest··NCT06765694·80 enrolled

Botulinum Toxin Injection After Sternotomies to Improve Scar Aspect and Impact

Not yet recruiting·UUniversity Hospital, Bordeaux·Phase 3·NCT07013240·50 enrolled

Botulinum Toxin and Saliva Management in Tracheotomised Patients

Withdrawn·HHCA International Limited·Phase 2·NCT00973999

Intrapapillary Botulinum Toxin Injection for PREvention of Post-surgical PAncREactic Fistula

Recruiting·AAssistance Publique - Hôpitaux de Paris·N/A·NCT04220931·460 enrolled

Atrial Fibrillation4 trials

Pulmonary Vein Isolation Versus Botulinum Toxin Injection Plus Pulmonary Vein Isolation in Patients With Atrial Fibrillation

Unknown status·MMeshalkin Research Institute of Pathology of Circulation·Phase 2·NCT02002923·160 enrolled

Botulinum Toxin Injection in Epicardial Fat Pads To Treat Atrial Fibrillation After Cardiac Surgery

Completed·MMeshalkin Research Institute of Pathology of Circulation·Phase 2·NCT01842529·60 enrolled

Botulinum Toxin Injection for Preventing Secondary Atrial Fibrillation in Patient With Supra-ventricular Tachyarrythmias

Unknown status·MMeshalkin Research Institute of Pathology of Circulation·Phase 2·NCT02008461·60 enrolled

Show 1 more trial

Botulinum Toxin Injection Into Epicardial Fat Pads to Prevent Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Unknown status·MMeshalkin Research Institute of Pathology of Circulation·Phase 2/3·NCT02617069·170 enrolled

Tremor3 trials

Essential Voice Tremor: A Study of Botulinum Toxin Treatment and Injection Augmentation

Completed·WWeill Medical College of Cornell University·N/A·NCT02711995·8 enrolled

Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET)

Completed·TThe Cleveland Clinic·N/A·NCT02909907·21 enrolled

Factors Determining the Efficacy of Botulinum Toxin for Arm Tremor in Dystonia: An Exploratory Study

Active, not recruiting·RRadboud University Medical Center·Approved·NCT06411028·60 enrolled

Spasticity2 trials

Dynamic Lycra Orthosis as an Adjunct to Botulinum Toxin-A Injection for Post-stroke Spasticity

Completed·MMarmara University·N/A·NCT03546959·20 enrolled

Botulinum Toxin Efficiency on Spasticity of Rectus Femoris and Semitendinosus Muscles as Functional Agonist and Antagonist Muscles

Completed·HHospices Civils de Lyon·Phase 2/3·NCT00133861·23 enrolled

Botox2 trials

Botox on Vulvar Vestibulitis

Unknown status·RRigshospitalet, Denmark·Phase 4·NCT00119886·64 enrolled

Low or High Botox Dilution for the Hemiplegic Gait?

Recruiting·UUniversity of Ioannina·Phase 1·NCT04630873·20 enrolled

34 more indications

Osteoarthritis2 trials

Assessment of Pain After Intra-articular Botulinum Toxin Injections in Carpometacarpal Osteoarthritis of the Thumb

Active, not recruiting·—·Phase 4·NCT04829565·60 enrolled

Dose-Escalation of Botulinum Toxin in Subjects With Osteoarthritis of the Knee

Completed·GGalderma R&D·Phase 1·NCT02139319·22 enrolled

Bruxism2 trials

Effectiveness of Botox, Dry Needling, Pharmacological Treatment, and Manual Therapy for Bruxism-Induced Myalgia

Completed·SSaglik Bilimleri Universitesi·N/A·NCT06583551·80 enrolled

Efficacy of Botulinum Toxin A in the Treatment of Bruxism-related Symptomatology

Terminated·—·Phase 3·NCT04722809·1 enrolled

Treatment2 trials

Effect of Different Treatment Techniques on Masseter Muscle Thickness

Completed·—·N/A·NCT06593821·48 enrolled

Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients

Completed·CCliniques universitaires Saint-Luc- Université Catholique de Louvain·Phase 3·NCT00825097·16 enrolled

Stroke2 trials

Using Shear Wave Ultrasound Elastography for Follow up After Anti-spastic Intervention Among Stroke Patients

Unknown status·NNational Taiwan University Hospital··NCT04550793·100 enrolled

Evaluation of Tibial Nerve Selective Neurotomy Compared to Botulinum Toxin Injections for Spastic Foot Treatment in Post-stroke Patients According to a Goal-centered Approach

Recruiting·HHospices Civils de Lyon·N/A·NCT05874154·60 enrolled

SMA1 trial

Botulinum-assisted Orbital Fat Augmentation With PRP (Platelet-rich-plasma)

Completed·FFox, Donald Munro, M.D., P.C.·N/A·NCT02244671·6 enrolled

Arthritis1 trial

Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis

Recruiting·RRhode Island Hospital·Phase 3·NCT05990881·50 enrolled

Parkinson's1 trial

The Use of Botox in Advanced Parkinson's Patients Experiencing Pain

Unknown status·UUniversity Health Network, Toronto·Phase 4·NCT02472210·14 enrolled

Randomized Controlled Trial1 trial

Randomized Controlled Trial Examining the Efficacy of Botulinum Toxin in Biopsy Scar Minimization

Active, not recruiting·HHenry Ford Health System·Phase 2/3·NCT05478551·12 enrolled

Cervical Dystonia1 trial

Long-term Outcome of DBS Versus Botulinum Toxin Treatment in Cervical Dystonia

Unknown status·OOslo University Hospital··NCT04432285·50 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Cyclops Syndrome After Anterior Cruciate Ligament Reconstruction

Active, not recruiting·GGCS Ramsay Santé pour l'Enseignement et la Recherche·Phase 3·NCT05008731·132 enrolled

Constipation1 trial

Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation

Unknown status·—·Phase 4·NCT02361749·40 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of the Full Face Applications of Variable Doses of a Commercial Botulinum Toxin Type a (Dysport®)

Completed·HHexsel Dermatology Clinic·Phase 4·NCT01032954·90 enrolled

Focal Dystonia1 trial

Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia

Completed·UUniversity Hospital, Grenoble·N/A·NCT03938363·40 enrolled

Moderate to Severe Glabellar Lines1 trial

Treatment of Moderate to Severe Glabellar Lines

Completed·GGalderma R&D·Phase 3·NCT04249583·300 enrolled

Dermatitis1 trial

Botulinum Toxin for Treatment of Seborrhic Dermatitis in Parkinsonian Patients

Unknown status·RRabin Medical Center·Phase 1·NCT00767546·40 enrolled

Headache1 trial

Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache

Completed·NNorwegian University of Science and Technology·Phase 2·NCT00184197·28 enrolled

Dystonia1 trial

Strategy to Adapt Botulinum Toxin Doses in Dystonia

Unknown status·—··NCT06386848·100 enrolled

Ventricular arrhythmia1 trial

Botulinum Toxin Injection to Prevent Ventricular Arrhythmias

Unknown status·MMeshalkin Research Institute of Pathology of Circulation·Phase 1·NCT02003001·30 enrolled

Ultrasound1 trial

Ultrasound and EMG Guided Botox Injection for the Treatment of Non-Relaxing Puborectalis Syndrome

Terminated·KKaren Noblett·Phase 2/3·NCT01780636·7 enrolled

Dementia1 trial

Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness

Completed·AAssistive Technology Clinic, Canada·Phase 2·NCT02212119·10 enrolled

Lateral Canthal Lines1 trial

Treatment of Moderate to Severe Lateral Canthal Lines

Completed·GGalderma R&D·Phase 3·NCT04249687·303 enrolled

Carpal Tunnel Syndrome1 trial

Botulinum Toxin for Carpal Tunnel Syndrome

Withdrawn·UUniversity of Minnesota·Phase 2·NCT00701233

Weight Management1 trial

Endoscopic Gastric Reduction for Weight Management

Completed·MMayo Clinic·Phase 1·NCT01682733·10 enrolled

Compartment Syndrome1 trial

Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS)

Completed·WWalter Reed National Military Medical Center·Phase 2·NCT04409600·35 enrolled

Endometriosis1 trial

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 1/2·NCT01553201·30 enrolled

Clubfoot1 trial

Using Botox to Treat Patients With Idiopathic Clubfoot

Unknown status·UUniversity of British Columbia·N/A·NCT00474032·2,000 enrolled

Spastic Cerebral Palsy1 trial

A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexion

Completed·YYonsei University·N/A·NCT02917967·31 enrolled

Scleroderma1 trial

The Effects of Botulinum Toxin on Oral Aperture in Patients With Scleroderma

Completed·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT04523506·17 enrolled

Head and Neck1 trial

EMG-Based Evaluation of Occlusal Splint and Masseter Botox Effects on Head and Neck Muscles

Recruiting·IIstanbul University·Phase 4·NCT07082972·56 enrolled

Myofascial Pain Syndrome1 trial

The Use of Botulinum Toxin in the Management of Myofascial Pain Syndrome

Completed·YYassir R. Al-khannaq·Phase 1/2·NCT06824324·14 enrolled

Cerebral Palsy1 trial

The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial

Completed·GGuy's and St Thomas' NHS Foundation Trust·Phase 3·NCT01437644·54 enrolled

Hypertensive1 trial

Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy

Completed·MMansoura University·N/A·NCT00927849·63 enrolled

Hidradenitis Suppurativa1 trial

Targeting Nociceptors in Hidradenitis Suppurativa

Recruiting·UUniversity of Massachusetts, Worcester··NCT05403710·20 enrolled

Raynaud Phenomenon1 trial

Double Blind RCT to Evaluate the Effect of Botulinum Toxin in Raynaud Phenomenon

Completed·EEmory University·Approved·NCT05125029·24 enrolled

Sources

References

[1]
ClinicalTrials.gov — 61 trial records for Botulinum Toxin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Botulinum Toxin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Botulinum Toxin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Meshalkin Research Institute of Pathology of Circulation company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: MMeshalkin Research Institute of Pathology of Circulation

Botulinum Toxin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Trials by Indication[1]

Botulinum Toxin12 trials

Atrial Fibrillation4 trials

Tremor3 trials

Spasticity2 trials

Botox2 trials

Osteoarthritis2 trials

Bruxism2 trials

Treatment2 trials

Stroke2 trials

SMA1 trial

Arthritis1 trial

Parkinson's1 trial

Randomized Controlled Trial1 trial

Cervical Dystonia1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Constipation1 trial

Safety and Efficacy1 trial

Focal Dystonia1 trial

Moderate to Severe Glabellar Lines1 trial

Dermatitis1 trial

Headache1 trial

Dystonia1 trial

Ventricular arrhythmia1 trial

Ultrasound1 trial

Dementia1 trial

Lateral Canthal Lines1 trial

Carpal Tunnel Syndrome1 trial

Weight Management1 trial

Compartment Syndrome1 trial

Endometriosis1 trial

Clubfoot1 trial

Spastic Cerebral Palsy1 trial

Scleroderma1 trial

Head and Neck1 trial

Myofascial Pain Syndrome1 trial

Cerebral Palsy1 trial

Hypertensive1 trial

Hidradenitis Suppurativa1 trial

Raynaud Phenomenon1 trial

References

Drug Info

Quick Facts

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