VivoSeq
Other

Calcification

36

Pipeline Programs↗

8

Active Trials↗

24

Companies Involved↗

Calcification is a moderately active landscape with 36 programs across 24 companies. The most active players are Sanifit Therapeutics S. A., Hope Pharmaceuticals, Roche. 13 therapies are approved with 5 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

56/100

Pipeline Velocity

11/100

Mech. Concentration

27/100

Completion Rate

85/100

Attrition Rate

11/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

S

Sanifit Therapeutics S. A.

1 program

Phase 2H

Hope Pharmaceuticals

1 program

Phase 2Roche logo

Roche

1 program

Phase 2K

K-Group Alpha, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc.

1 program

Phase 2V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2Sanofi logo

Sanofi

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical6

Calcium Carbonate

Otsuka

Sevelamer

Genzyme, a Sanofi Company

Gemigliptin

LG Chem

Phytomenadione

Eli Lilly

Zortress /everolimus

University of Kentucky

Phase 11

Copper Cu-64-DOTA-Alendronate

City of Hope Medical Center

Phase 211

Sodium Thiosulfate

Hope Pharmaceuticals

Alfacalcidol

Roche

Manidipine

University of Erlangen-Nürnberg Medical School

Etelcalcetide

K-Group Alpha, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc.

Etidronate

Vitae Pharmaceuticals Inc., an Allergan affiliate

Phase 35

Dapagliflozin

AstraZeneca

Dexamethasone

Aspen Global Incorporated

Spironolactone

Pfizer

Cholecalciferol

Hyundai Pharmaceutical Co., LTD.

Acetazolamide

Teva

Approved13

Rivaroxaban

Wim Janssens

Atorvastatin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Melatonin

Neurim Pharmaceuticals Ltd.

Warfarin

Abbott

Apixaban

Bristol-Myers Squibb

Analysis

Modality Breakdown

98%

Small molecule

44 of 45 classified programs — the dominant modality here.

2%ALL OTHERSPeptide12%

Small molecule leads; the ring shows all 45 classified programs, each share of the total. Modality classified for 100% of 47 pipeline programs.

Analysis

Trial Status

45

clinical trials

Completed28 · 62%
Recruiting6 · 13%
Unknown status4 · 9%
Withdrawn3 · 7%
Not yet recruiting2 · 4%
Terminated2 · 4%

Clinical Trials

Trial Activity

45 trials

Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock
Recruiting·—·N/A·NCT06853340·66 enrolled
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study
Recruiting·UUniversity Hospital, Limoges·Phase 2·NCT03582800·40 enrolled
GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification
Recruiting·—·Phase 4·NCT06722521·7,435 enrolled
Neutrophil Gelatinase-associated Lipocalin VS Vascular Calcification in Maintenance Hemodialysis Patients
Recruiting·—·Phase 4·NCT05720273·80 enrolled
Treatment of Ectopic Calcification in Fahr's Disease or Syndrome
Recruiting·UUMC Utrecht·Phase 2·NCT05662111·98 enrolled
Diagnosis and Treatment of Patients With Inborn Errors of Metabolism or Other Genetic Disorders
Recruiting·NNational Human Genome Research Institute (NHGRI)·N/A·NCT00369421·4,000 enrolled
Exploration of Manidipine to Reverse Aortic Valve Calcification
Not yet recruiting·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 2·NCT07091136·100 enrolled
Renal and Vascular Phenotypic Characterization of Patients With Enamel Renal Syndrome Due to a Pathogenic Variant of the FAM20A Gene and Pathophysiological Study of Ectopic Calcifications
Not yet recruiting·AAssistance Publique - Hôpitaux de Paris·N/A·NCT07285421·30 enrolled
Can Alendronate Suppress Calcification and Improve Bone Density in Chronic Peritoneal Dialysis Patients?
Completed·NNational Taiwan University Hospital·Phase 4·NCT00261625·50 enrolled
64 Cu-DOTA-alendronate PET Imaging in Localizing and Characterizing Breast Calcifications in Participants Before Undergoing Mastectomy
Completed·—·Phase 1·NCT03542695·1 enrolled
CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients
Completed·NNabi Biopharmaceuticals·Phase 4·NCT00211939·203 enrolled
Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation
Completed·UUniversity Hospital, Angers·Phase 4·NCT02161965·51 enrolled
Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)
Completed·National Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT01585402·7 enrolled
Effects of Fhytomenadione on Coronary Artery Calcification of Hemodialysis Patients
Completed·IInstituto Mexicano del Seguro Social·N/A·NCT04247087·60 enrolled
SGLT2 Inhibitors in Non-Diabetic CKD: Effects on Vascular Calcification and Anemia
Completed·MMansoura University·Phase 3·NCT07344922·100 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)