Explore

Companies

Drugs

About·Data Management·Terms·Privacy

Stay informed

© 2026 VivoSeq. All rights reserved.

Tums

(Calcium Carbonate)

ApprovedSmall molecule

Calcium carbonate is used to treat heartburn and acid indigestion by neutralizing stomach acid, and it's also taken as a calcium supplement to strengthen bones and prevent osteoporosis.[2] Tums is currently approved and in use across 31 indications[4].[1]

Tums is one of 607 small molecule programs targeting Calcification. It is currently in Approved.

31

Indications

57

Total Trials

6

Active Trials

606

Competitors

Pipeline

Status by Indication[4][1]

Indication

CalcificationActive, not recruiting

HIV InfectionActive, not recruiting

Cirrhosis of LiverActive, not recruiting

Vitamin D DeficiencyActive, not recruiting

Heart Valve DiseaseActive, not recruiting

Colonic NeoplasmActive, not recruiting

Familial Adenomatous PolyposisActive, not recruiting

Bone DiseaseActive, not recruiting

Thyroid NeoplasmActive, not recruiting

OsteopeniaActive, not recruiting

CalcificationPreclinical

Active, not recruiting

HIV InfectionPhase 2

Active, not recruiting

Cirrhosis of LiverPhase 3

Active, not recruiting

Vitamin D DeficiencyPhase 3

Active, not recruiting

Heart Valve DiseaseApproved

Active, not recruiting

Colonic NeoplasmPhase 1

Active, not recruiting

Familial Adenomatous PolyposisPhase 3

Active, not recruiting

Bone DiseasePreclinical

Active, not recruiting

Thyroid NeoplasmPreclinical

Active, not recruiting

OsteopeniaPhase 2

Active, not recruiting

Showing 10 of 30 indications

Competition

Competitive Landscape

885 competitors in Type 2 Diabetes

#DrugCompanyPhaseTrials

Tums

Byetta

Jardiance

Boehringer Ingelheim

NOVOLIN R

Glargine

Inspra

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Aurlumyn

BBTG International Inc.

Nexium

DDexcel Pharma Technologies Ltd.

Inderal

WWyeth-Lederle Vaccines

Pravachol

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Cardiopulmonary Bypass

NCT05593627

Clinical

Trials by Indication[1]

Muscle Cramp3 trials

Gabapentin in Treatment of Muscle Cramps in Patients With Liver Cirrhosis

Unknown status·TTanta University·Phase 3·NCT02642484·200 enrolled

Methocarbamol in Treatment of Muscle Cramps in Cirrhotic Patients

Unknown status·TTanta University·Phase 3·NCT02642874·200 enrolled

Cyclobenzaprine in Muscle Cramps With Liver Cirrhosis

Unknown status·TTanta University·Phase 3·NCT02642861·200 enrolled

Hyperphosphatemia3 trials

Lanthanum Versus Calcium Carbonate for Vascular Abnormalities in Patients With CKD and Hyperphosphatemia

Unknown status·OOsaka University·Phase 4·NCT02237534·60 enrolled

Efficacy and Safety of Cholestyramine in the Management of Hyperphosphatemia in Adult Hemodialysis Patients

Completed·—·Phase 4·NCT05577507·80 enrolled

Nicotinic Acid in Hemodialysis Patients With Hyperphosphatemia

Unknown status·JJiujiang No.1 People's Hospital·Phase 4·NCT02836184·45 enrolled

Osteoporosis3 trials

MK-5442 in the Treatment of Osteoporosis in Postmenopausal Women Previously Treated With an Oral Bisphosphonate (MK-5442-012)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00996801·526 enrolled

Adding Phosphorus to Osteoporosis Drug Treatment

Completed·—·Phase 2·NCT00074711·241 enrolled

Heartland Osteoporosis Prevention Study

Completed·UUniversity of Nebraska·Phase 3·NCT02186600·276 enrolled

Vitamin D3 trials

Vitamin D and Muscle Strength and Surface (Electromyography) EMG

Completed·IIndian Council of Medical Research·Phase 3·NCT01190683·170 enrolled

The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF

Completed·MMahidol University·Phase 4·NCT05313477·64 enrolled

The Effect of Alendronate, Calcium, and Vitamin D on Bone Mineral Density in HIV Infected Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00061256·80 enrolled

Chronic Kidney Disease2 trials

The Effectiveness and Safety of Calcium Carbonate in Chronic Kidney Disease With Normophosphatemia

Completed·IIndonesia University·N/A·NCT03550534·46 enrolled

A Study to Assess the Pharmacokinetics of Lanthanum Carbonate, Investigate and Compare the Efficacy, Safety and Tolerability of Lanthanum Carbonate With Calcium Carbonate in Hyperphosphataemic Children and Adolescents With Chronic Kidney Disease on Dialysis

Completed· Takeda logo

Takeda·Phase 2·NCT01696279·63 enrolled

39 more indications

Diabetic Nephropathy2 trials

The Effects of Sevelamer Carbonate on Diabetic Nephropathy

Completed·GGary Striker·Phase 2·NCT01493050·117 enrolled

Effect of Sevelamer Carbonate on Oxidative Stress in Patients With Diabetic Nephropathy

Completed·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT00967629·20 enrolled

End-Stage Renal Disease2 trials

Sevelamer Hydrochloride and Femoral and Carotid Intima Media Thickness Progression in End Stage Renal Disease

Completed·TTel-Aviv Sourasky Medical Center·N/A·NCT01049815·175 enrolled

Two phosphAte taRGets in End-stage Renal Disease Trial (TARGET)

Completed·UUnity Health Toronto·Phase 2·NCT01994733·104 enrolled

Prevention2 trials

A Study on the Prevention and Treatment of GIOP With Eldecalcitol

Not yet recruiting·CChinese SLE Treatment And Research Group·Phase 4·NCT06385093·314 enrolled

Vitamin D/Calcium Polyp Prevention Study

Completed·—·Phase 2/3·NCT00153816·2,813 enrolled

Labor2 trials

Calcium Carbonate to Augment Labor Contractions

Recruiting·WWeill Medical College of Cornell University·Phase 4·NCT06580782·60 enrolled

Oral Calcium Supplementation in Labor

Completed·—·Phase 2/3·NCT07056062·89 enrolled

Renal Osteodystrophy1 trial

Regulation of Bone Formation in Renal Osteodystrophy

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT00560300·61 enrolled

Growth1 trial

The Effect of Lanthanum Carbonate on Fibroblast Growth Factor 23

Unknown status·—·Phase 4·NCT01845090·30 enrolled

Colon Cancer1 trial

Aquamin and Prevention of Colon Cancer

Completed·JJames Varani·Phase 1·NCT02647671·36 enrolled

Diarrhea1 trial

A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated Diarrhea

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00650637·17 enrolled

Postmenopausal Women1 trial

Effect of Laser Acupuncture on Forearm Bone Mineral Density and Wrist Pain in Osteoporotic Postmenopausal Women

Completed·—·N/A·NCT05559619·68 enrolled

Alcohol Dependence1 trial

Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence

Completed·TTechnische Universität Dresden·Phase 3·NCT03634917·82 enrolled

Hypoparathyroidism1 trial

Efficacy of Calcium Citrate Versus Calcium Carbonate for the Management of Chronic Hypoparathyroidism

Completed·—·Phase 4·NCT03425747·26 enrolled

Heart Valve Disease1 trial

Calcium-Phosphorus Regulation Therapy on Heart Valve Disease

Recruiting·CChina National Center for Cardiovascular Diseases·Phase 4·NCT06660524·196 enrolled

Interaction1 trial

A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196

Completed·AAcerta Pharma BV·Phase 1·NCT04914936·72 enrolled

Rickets1 trial

Role of Calcium And Vitamin D In Nutritional Rickets And It's Management

Completed·LLady Hardinge Medical College·Phase 4·NCT01578434·67 enrolled

Drug Interactions1 trial

A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05109390·72 enrolled

Bone Health1 trial

High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART

Completed·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 2·NCT01403051·167 enrolled

Thoracic Surgery1 trial

Effect of Lithium Carbonate on Postoperative Sleep in Patients Undergoing Videoassisted Thoracic Surgery

Completed·—·Phase 4·NCT04479566·51 enrolled

Type 2 Diabetes1 trial

Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes

Completed·TTufts Medical Center·Phase 1/2·NCT00436475·92 enrolled

Trial1 trial

A Trial of C13-CAC Breath Test in PPI Resistant GERD Patients

Completed· Otsuka logo

Otsuka·Phase 2·NCT03284177·55 enrolled

Oral1 trial

Pharmacokinetics of Oral Calcium Carbonate in Parturients

Not yet recruiting·SStanford University·Phase 1·NCT06650930·60 enrolled

Cardiopulmonary Bypass1 trial

Effect of Lithium Carbonate on Postoperative Sleep and Cognitive Function in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass

Recruiting·—·Phase 4·NCT05593627·62 enrolled

Gastric1 trial

Comparison Study Between C13-CAC Breath Test and 24-hour Gastric pH Monitoring

Completed· Otsuka logo

Otsuka·Phase 2·NCT02225067·40 enrolled

CAR1 trial

A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants

Completed· Bayer logo

Bayer·Phase 1·NCT06293326·21 enrolled

Adult Subject1 trial

A Study to Evaluate the Effects of Calcium Carbonate and Ferrous Fumarate on Pharmacokinetics of Dolutegravir in Healthy Adult Subjects

Completed· GSK logo

GSK·Phase 1·NCT01762995·24 enrolled

Function1 trial

Acetate and Age-associated Arterial Dysfunction

Recruiting·UUniversity of Colorado, Denver·Phase 2·NCT05424263·66 enrolled

Osteopenia1 trial

Phase II Randomized Study of Alendronate Sodium for Osteopenia in Patients With Gaucher's Disease

Completed·—·Phase 2·NCT00004488·82 enrolled

Bone Disease1 trial

Pamidronate, Vitamin D, and Calcium for the Bone Disease of Kidney and Heart Transplantation

Completed·PProvidence Health & Services·N/A·NCT00302627·43 enrolled

Dialysis Patients1 trial

Outcome Study of Lanthanum Carbonate Compared With Calcium Carbonate in Hemodialysis Patients : Landmark Study

Completed·TTranslational Research Center for Medical Innovation, Kobe, Hyogo, Japan·Phase 3·NCT01578200·2,309 enrolled

Thyroid Surgery1 trial

Vitamin D Supplementation After Parathyroid Surgery

Completed·KKarolinska University Hospital·N/A·NCT00982722·150 enrolled

Double-blind1 trial

Phase III Double-blind Comparative Study of BAY77-1931 (Lanthanum Carbonate) With Calcium Carbonate

Completed· Bayer logo

Bayer·Phase 3·NCT01514851·259 enrolled

Chronic Renal Failure1 trial

Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)

Withdrawn·KKarolinska Institutet·N/A·NCT00837655

Phase II1 trial

Nordic 8 - A Phase II Trial

Completed·PPer Pfeiffer·Phase 2·NCT01867697·173 enrolled

Weight Management1 trial

Effect of Calcium + Vitamin D Supplementation on Weight Management in Very-low Calcium Consumers

Completed·—·Phase 4·NCT01447433·53 enrolled

Calcification1 trial

Reduce Cardiovascular Calcifications to Reduce QT Interval in Dialysis

Completed·AAzienda Sanitaria ASL Avellino 2·N/A·NCT00710788·360 enrolled

Cystic Fibrosis1 trial

Randomized Study of Alendronate in Adult Patients With Cystic Fibrosis Related Osteoporosis

Completed·UUniversity of North Carolina·N/A·NCT00004489·60 enrolled

Radiotherapy1 trial

A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy

Withdrawn·—·Phase 1·NCT03612466

Chemotherapy1 trial

Effect of Zoledronic Acid on Chemotherapy Induced Bone Loss

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00352846·135 enrolled

Rheumatoid Arthritis1 trial

Calcium Supplements for Bone Health in Juvenile Rheumatoid Arthritis

Completed·—·Phase 2·NCT00000429·192 enrolled

Unspecified1 trial

Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol

Completed·SSeoul National University Hospital·Phase 4·NCT01748396·30 enrolled

Sources

References

[1]
ClinicalTrials.gov — 57 trial records for Calcium Carbonate. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Tums drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Calcium Carbonate compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Calcium Carbonate. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Otsuka company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Otsuka

Related News