VivoSeq
Gastroenterology

Chronic Constipation

33

Pipeline Programs

3

Active Trials

17

Companies Involved

Chronic constipation is a moderately active landscape with 33 programs across 17 companies. The most active players are Motus Therapeutics, Inc., Ironwood Pharmaceuticals, Inc., Kissei Pharmaceutical Co., Ltd.. 8 therapies are approved with 10 more in late-stage development.

Pipeline Metrics

Competitive Density

53/100

Pipeline Velocity

6/100

Mech. Concentration

20/100

Completion Rate

89/100

Attrition Rate

10/100

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Programs by Phase

Modality Breakdown

97%

Small molecule

38 of 39 classified programs — the dominant modality here.

3%ALL OTHERSPeptide13%

Small molecule leads; the ring shows all 39 classified programs, each share of the total. Modality classified for 100% of 41 pipeline programs.

Trial Status

73

clinical trials

Completed55 · 75%
Unknown status8 · 11%
Terminated5 · 7%
Withdrawn2 · 3%
Not yet recruiting2 · 3%
Recruiting1 · 1%

Trial Activity

73 trials

"Efficacy and Safety of Linaclotide in Chronic Constipation"
Not yet recruiting··Phase 4·NCT07431957·90 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)