Diprivan

(Propofol)

ApprovedSmall molecule

Propofol is used to put patients to sleep before surgery and medical procedures, and to keep them sedated while on a ventilator in the hospital. It works quickly to make someone unconscious and is commonly used by anesthesiologists.[2] Diprivan is currently approved and in use across 146 indications[4].[1]

Diprivan is one of 1947 small molecule programs targeting Glioma. It is currently in Approved.

146

Indications

917

Total Trials

Active Trials

1,946

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

GliomaActive, not recruiting

Coronary Artery DiseaseApproved

Childhood Acute Lymphoblastic LeukemiaActive, not recruiting

Premature BirthApproved

Cirrhosis of LiverApproved

ArrhythmiaActive, not recruiting

Neuropathic PainActive, not recruiting

Cardiac ArrestActive, not recruiting

Paroxysmal Familial Ventricular FibrillationActive, not recruiting

CholangitisActive, not recruiting

GliomaPreclinical

Active, not recruiting

Coronary Artery DiseaseApproved

Approved

Childhood Acute Lymphoblastic LeukemiaPreclinical

Active, not recruiting

Premature BirthApproved

Approved

Cirrhosis of LiverApproved

Approved

ArrhythmiaPreclinical

Active, not recruiting

Neuropathic PainApproved

Active, not recruiting

Cardiac ArrestPhase 2

Active, not recruiting

Paroxysmal Familial Ventricular FibrillationPreclinical

Active, not recruiting

CholangitisApproved

Active, not recruiting

Showing 10 of 134 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Diprivan

FFresenius Kabi Oncology Ltd.

Approved

2 2

Tykerb

GSK

Preclinical

80 3

Trodelvy

Gilead

Preclinical

37 4

Lexiscan

Astellas

Preclinical

1 5

Voltaren

Novartis

Preclinical

1 6

Spravato

WWim Janssens

Preclinical

2 7

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 8

Aquasol E

NNational Eye Institute (NEI)

Paracetamol

1 10

Vit D

PPost Graduate Institute of Medical Education and Research, Chandigarh

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Recruiting

General Anesthetics

NCT05210764

N/ANot yet recruiting

Hypotension

NCT07460050

Recruiting

Parkinson's Disease

NCT05895019

Q4 2026

Post-ApprovalRecruiting

Bladder Cancer

NCT04532606

Post-ApprovalRecruiting

Prognosis

NCT05663242

N/ANot yet recruiting

Coronary Artery Bypass

NCT06496165

Clinical

Trials by Indication[1]

Sedation23 trials

A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial

Completed·YYonsei University·Phase 4·NCT01895348·60 enrolled

RCT of Efficacy and Safety of Sedation Compared to General Anesthesia for ERCP

Terminated·EErasme University Hospital·N/A·NCT02046590·120 enrolled

Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup

Recruiting·WWunschbaby Institut Feichtinger·N/A·NCT05741814·100 enrolled

Show 20 more trials

Balanced Propofol Sedation Versus Propofol Alone Sedation in Therapeutic Endoscopic Retrograde Cholangiopancreatography (ERCP)

Unknown status·SSoon Chun Hyang University·Phase 4·NCT01321047·204 enrolled

A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy

Recruiting·—·Phase 4·NCT07456111·90 enrolled

A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation

Completed· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 2·NCT04669821·20 enrolled

The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy

Completed·UUfuk University·Phase 4·NCT02486328·103 enrolled

Responsiveness Index Versus the RASS Based Method for Adjusting Sedation in Critically Ill Patients

Completed·HHelsinki University Central Hospital·N/A·NCT03250481·32 enrolled

General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke

Completed·RRennes University Hospital·Phase 3·NCT02822144·351 enrolled

Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy

Completed·SState University of New York - Downstate Medical Center·Phase 4·NCT03139279·122 enrolled

Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Healthy Volunteers

Completed·SSonia Allam·Phase 4·NCT00321360·20 enrolled

Trial Comparing Sedation for Endoscopy With Propofol Versus Midazolam in Cirrhotics

Unknown status·GGovind Ballabh Pant Hospital·Phase 4·NCT01356121·120 enrolled

The Deep Sedation for Ablation Study

Completed·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT03844841·160 enrolled

Sedation in Patients at Risk for Upper Airway Collapse

Completed·UUniversity of Rochester·N/A·NCT01045122·15 enrolled

Bispectral Index(BIS) on Depth of Sedation With Dexmedetomidine, Propofol and Midazolam During Spinal Anesthesia

Unknown status·HHallym University Medical Center·N/A·NCT03399019·45 enrolled

Sedation and Pain (The Effect of IV Sedation on Pain Perception)

Completed·UUniversity of Alabama at Birmingham·N/A·NCT00853333·86 enrolled

Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)

Completed·HHennepin Healthcare Research Institute·Phase 4·NCT00997321·100 enrolled

Paradoxical Excitement Response During Sedation Between Dexmedetomidine and Propofol in Hazardous Alcohol Drinker

Unknown status·—·Phase 4·NCT02197403·110 enrolled

Digital Sedation: Virtual Reality Hypnosis During Colonoscopy

Terminated·OOncomfort·N/A·NCT04465383·90 enrolled

Stress During Deep Sedation With Propofol With and Without Alfentanil

Completed·HHennepin Healthcare Research Institute·Phase 4·NCT00997113·20 enrolled

Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)

Completed·SSedana Medical·Phase 3·NCT05327296·282 enrolled

Automated Postoperative Sedation After Cardiac Surgery

Terminated·CCMC Ambroise Paré·N/A·NCT03517735·7 enrolled

Electroencephalogram Based Real-Time Sedation Level Prediction

Unknown status·UUniversity Medical Center Groningen··NCT05757622·1,000 enrolled

Delirium9 trials

Sevoflurane and Propofol Anesthesia on Postoperative Delirium

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT01995214·500 enrolled

Effect of Remimazolam and Propofol on Postoperative Delirium

Recruiting·IInje University·N/A·NCT05514405·82 enrolled

Comparison of Dexmedetomidine and Propofol on the Delirium and Neuroinflammation in Patients With SIRS.

Withdrawn·MMoscow Regional Research and Clinical Institute (MONIKI)·Phase 4·NCT02366299

Show 6 more trials

Decreasing the Incidence of Delirium After Cardiac Surgery

Withdrawn·UUniversity of California, Los Angeles·Phase 4·NCT02119806

Intraoperative Sedation and Postoperative Delirium

Completed·SSeoul National University Bundang Hospital··NCT02573558·855 enrolled

Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia

Completed·UUniversity of British Columbia·N/A·NCT00885443·112 enrolled

The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

Recruiting·MMedical University of Vienna·Phase 4·NCT05990790·1,332 enrolled

Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients

Withdrawn·MMoscow Regional Research and Clinical Institute (MONIKI)·Phase 4·NCT02394418

The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients

Completed·FFang Jun·N/A·NCT05466279·131 enrolled

Propofol6 trials

Propofol Pharmacokinetics and Pharmacodynamics Modelling

Completed·—··NCT02713698·60 enrolled

A Study to Assess the Transfer of Fospropofol and Its Active Metabolite, Propofol, to Breast Milk Following Administration of LUSEDRA to Lactating Women Undergoing a Needed Procedure

Completed· Eisai logo

Eisai·Phase 1·NCT01309984·10 enrolled

Use of a Modified Propofol Emulsion in Adults

Completed·BB. Braun Melsungen AG·Phase 3·NCT00690495·100 enrolled

Show 3 more trials

Effects of Propofol on Early Recovery of Hunger After Surgery

Completed·UUniversity Hospital, Rouen·Phase 4·NCT02272166·116 enrolled

Population Pharmacokinetics/Pharmacodynamics (PK/PD) of Microemulsion Propofol in Healthy Volunteers

Completed·—·Phase 1·NCT00908726·63 enrolled

Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

Completed·OOrdu University·Phase 4·NCT02186990·90 enrolled

Anesthesia6 trials

Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI

Terminated·SState University of New York at Buffalo·Phase 4·NCT02111447·6 enrolled

Impact of Anesthesia Maintenance Methods on Long-term Survival

Completed·PPeking University First Hospital·N/A·NCT02660411·1,228 enrolled

Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

Not yet recruiting·—·Phase 4·NCT07348614·128 enrolled

Show 3 more trials

Effects of Anesthesia on Immunity in Cancer

Completed·MMeshalkin Research Institute of Pathology of Circulation·Phase 4·NCT03514550·20 enrolled

Comparing Ketamine and Propofol Anesthesia for Electroconvulsive Therapy

Completed·UUniversity of Saskatchewan·Phase 4·NCT01935115·27 enrolled

An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia

Completed·OOsijek University Hospital··NCT04235894·124 enrolled

Sevoflurane6 trials

Does Sevoflurane Cause Genomic Damage

Unknown status·JJubilee Mission Medical College and Research Institute·Phase 4·NCT03109119·30 enrolled

Propofol Versus Sevoflurane During FESS

Unknown status·AAlgemeen Ziekenhuis Maria Middelares·Phase 4·NCT04619160·60 enrolled

Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

Completed·RRutgers, The State University of New Jersey··NCT01219569·35 enrolled

Show 3 more trials

Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Completed·UUppsala University·Phase 4·NCT01975064·5,774 enrolled

Sevoflurane, Propofol and Desflurane on POD/POCD

Unknown status·SShanghai 10th People's Hospital··NCT03326960·300 enrolled

Early Cardioprotective Effect of Sevoflurane

Completed·UUniversity Hospital Dubrava·Phase 4·NCT00477737·32 enrolled

112 more indications

Agitation5 trials

The Effect of Propofol Versus Lidocaine on Emergence Agitation in Children Undergoing Tonsillectomy.

Not yet recruiting·—·Phase 4·NCT07268924·82 enrolled

Dexmedetomidine and Propofol in the Treatment of Emergence Agitation

Unknown status·RRenJi Hospital·Phase 1·NCT04142840·120 enrolled

The Effect of Induction Technique on Postoperative Pain and Agitation

Completed·MMustafa Kemal University·Phase 4·NCT02110745·2 enrolled

Show 2 more trials

Transition to Propofol After Sevoflurane Anaesthesia to Prevent Emergence Agitation

Completed·—·Phase 4·NCT03179293·70 enrolled

Propofol in Emergence Agitation

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT00535613·99 enrolled

Efficacy and Safety5 trials

A Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion for the Induction of General Anesthesia in Elective Surgery Subjects

Completed·SSichuan Haisco Pharmaceutical Group Co., Ltd·Phase 3·NCT03808844·178 enrolled

Efficacy and Safety of Fospropofol for Same-day Bidirectional Endoscopy in Elderly Patients

Not yet recruiting·SShanghai 6th People's Hospital·Phase 4·NCT06251999·256 enrolled

A Study Evaluating the Efficacy and Safety of HSK3486

Completed·SSichuan Haisco Pharmaceutical Group Co., Ltd·Phase 2·NCT03709056·94 enrolled

Show 2 more trials

A Study to Evaluate the Efficacy and Safety of HSK3486 in the Induction of General Anesthesia

Completed· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 3·NCT04511728·129 enrolled

Efficacy and Safety of Ciprofol Compared to Propofol for Nonintubated General Anesthesia in Patients Undergoing TAVR

Unknown status· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 4·NCT05035069·24 enrolled

Remimazolam4 trials

Effect of Remimazolam on Motor Evoked Potential

Completed·KKorea University Guro Hospital·N/A·NCT05453955·20 enrolled

Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments

Recruiting·KKaohsiung Veterans General Hospital.·Phase 4·NCT06777758·90 enrolled

Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway Surgery

Recruiting·—·Phase 4·NCT06507202·116 enrolled

Show 1 more trial

Varied Remimazolam Dosages for Pediatric Endoscopy

Completed·—·N/A·NCT07083440·180 enrolled

Total Intravenous Anesthesia4 trials

Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Completed·MMedical University Innsbruck·Phase 4·NCT00706277·60 enrolled

Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block

Completed·MMaimonides Medical Center·Phase 4·NCT02469961·50 enrolled

Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery

Completed·TTaichung Veterans General Hospital·N/A·NCT03263078·78 enrolled

Show 1 more trial

Comparison of Optic Nerve Sheath Diameter in Children Receiving Caudal Block According to Anesthetic Agents: Total Intravenous Anesthesia vs. Volatile Anesthesia

Completed·YYonsei University·N/A·NCT04415905·60 enrolled

General Anesthetics3 trials

General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

Completed·SStony Brook University·Phase 4·NCT03034096·1,826 enrolled

General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia

Recruiting·PPeking University First Hospital··NCT05210764·366 enrolled

The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects

Completed·MMassachusetts General Hospital·Phase 4·NCT01557920·18 enrolled

Bronchoscopy3 trials

Remifentanil Use in Pediatric Rigid Bronchoscopy

Completed·—·Phase 4·NCT01947114·40 enrolled

Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy

Completed·HHospital Universitario Dr. Jose E. Gonzalez·N/A·NCT02820051·102 enrolled

Esketamine-propofol Versus Propofol for Flexible Bronchoscopy

Completed·FFujian Provincial Hospital·Phase 4·NCT05643066·246 enrolled

Intraoperative3 trials

Intraoperative Sedatives and Postoperative Deilirium

Completed·SSeoul National University Bundang Hospital·N/A·NCT03251651·748 enrolled

NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane

Completed·CCiusss de L'Est de l'Île de Montréal·Phase 4·NCT04567160·60 enrolled

UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT03284307·35 enrolled

Hemodynamic Stability3 trials

Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia

Withdrawn·YYale University·Phase 2·NCT02282891

Subanesthetic Esketamine for Hemodynamic Stability and Recovery in Elderly Thoracic Surgery Patients

Completed·HHebei Medical University Fourth Hospital·N/A·NCT07064408·230 enrolled

Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients

Completed·SSeoul National University Hospital·N/A·NCT05423951·106 enrolled

Oxidative Stress2 trials

Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy

Completed·RRennes University Hospital·Phase 3·NCT00219856·34 enrolled

Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Unknown status·ZZhujiang Hospital·Phase 4·NCT02202239·60 enrolled

Elderly Patients2 trials

Etomidate to Improve Outcome in Elderly Patients

Completed·ZZhihong LU·N/A·NCT02910206·1,917 enrolled

Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients

Completed·TTongji Hospital·N/A·NCT05801757·114 enrolled

Tracheal Intubation2 trials

Ciprofol Versus Propofol for Tracheal Intubation in ICU

Completed·SShanghai Zhongshan Hospital·Phase 4·NCT06344949·100 enrolled

Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction

Completed·UUniversity of Virginia·Phase 4·NCT01150838·106 enrolled

Colonoscopy2 trials

Inhaled Sevofluran vs Endovenous Propofol for Colonoscopy

Completed·CCentro Medico Docente la Trinidad·N/A·NCT03818048·32 enrolled

Explore the Clinical Application Value of Ciprofol in Painless Colonoscopy

Completed·SSichuan Provincial People's Hospital·N/A·NCT05294679·110 enrolled

Post Operative Pain2 trials

Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects

Withdrawn·TThe University of Hong Kong··NCT03058354

The Influence of Type of Anesthesia on Postoperative Pain

Unknown status·SSeoul National University Hospital·N/A·NCT04239794·468 enrolled

Nausea and vomiting2 trials

Effect of Propofol on Postoperative Nausea and Vomiting.

Completed·PPakistan Air Force (PAF) Hospital Islamabad·Phase 4·NCT05071794·60 enrolled

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Acute Respiratory Distress Syndrome2 trials

Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome

Recruiting·GGuy's and St Thomas' NHS Foundation Trust·Phase 2/3·NCT06014138·20 enrolled

Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection

Terminated·FFundación para la Investigación del Hospital Clínico de Valencia·Phase 4·NCT04359862·19 enrolled

Pediatric2 trials

Predictive Model in EEG for Induction and Emergence in Pediatric With Propofol

Terminated·VVictor Contreras, MSN··NCT03705338·1 enrolled

Ketamine Compared to Propofol for Pediatric GI Endoscopy

Completed·SState University of New York - Upstate Medical University··NCT00614159·34 enrolled

Hypotension2 trials

Ciprofol Titrated Induction in Reducing Post-induction Hypotension in Geriatric Patients

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·N/A·NCT06258967·160 enrolled

Comparison of Two Sedative Agents in Terms of Controlled Hypotension

Not yet recruiting·HHayatabad Medical Complex·N/A·NCT07460050·136 enrolled

Intensive Care Unit2 trials

Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)

Terminated·UUniversity of Chicago·Phase 4·NCT01059929·41 enrolled

Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)

Terminated· GSK logo

GSK·Phase 3·NCT00436345·39 enrolled

Concentration2 trials

A Pilot Study to Investigate Plasma Bupivacaine Concentrations in Children Receiving Total Intravenous Anaesthesia and Caudal Analgesia

Completed·UUniversity of British Columbia·Phase 1/2·NCT01216007·30 enrolled

Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children

Unknown status·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University·N/A·NCT03595163·80 enrolled

Anesthesia Induction2 trials

Left Ventricular Diastolic Function During Anesthesia Induction

Completed·UUniversitätsklinikum Hamburg-Eppendorf··NCT03522194·200 enrolled

Clinical Observation of Ciprofol for Anesthesia Induction

Unknown status·XXiumei Song·Phase 4·NCT05706337·90 enrolled

General Anesthesia2 trials

The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function

Not yet recruiting·TThe Second Affiliated Hospital of Chongqing Medical University·N/A·NCT06775366·174 enrolled

The Relationship Between Different Doses of Propofol and the Occurrence of Dreams in Short Surgery Under General Anesthesia

Completed·SShengjing Hospital·N/A·NCT05173688·300 enrolled

Open Heart Surgery2 trials

Neuroprotection During Open Heart Surgery

Completed·Gghada fouad·Phase 3·NCT04486690·50 enrolled

Influence of Anesthesia on Mechanical Efficiency of Left Ventricle in Patients Undergoing Open Heart Surgery

Terminated·SSheba Medical Center·Phase 4·NCT01397331·28 enrolled

Aesthetic2 trials

Comparison of Two Anaesthetics on Brain During Brain Tumour Surgery

Completed·UUniversity Medical Centre Ljubljana·Phase 1·NCT02229201·40 enrolled

The Use of Ketamine as an Anaesthetic During Electroconvulsive Therapy

Completed·UUniversity of Aberdeen·Phase 4·NCT01306760·40 enrolled

Glioma1 trial

The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma

Recruiting·—··NCT06138340·120 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Shoulder Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT03540030·86 enrolled

Coronary Artery Bypass1 trial

Remimazolam Besylate and Propofol Sedation on Hemodynamic for Coronary Artery Bypass Graft Patients

Not yet recruiting·SShanghai Zhongshan Hospital·N/A·NCT06496165·338 enrolled

Central Nervous System1 trial

Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users

Completed·HHaisco-USA Pharmaceuticals, Inc.·Phase 1·NCT07404306·43 enrolled

Atrial Fibrillation1 trial

Comparison of Remimazolam With Flumazenil vs. Propofol During RFCA for Atrial Fibrillation

Completed·SSeoul National University Hospital·N/A·NCT05397886·54 enrolled

Breast Surgery1 trial

Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00542542·89 enrolled

PONV1 trial

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

Completed·—·Phase 4·NCT02809378·150 enrolled

Completed·SShandong University·N/A·NCT01053871·104 enrolled

Cognitive Functions1 trial

Cognitive Functions After TIVA With Dexmedetomidine

Completed·UUludag University·Phase 4·NCT02631135·40 enrolled

Hip Fracture1 trial

Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel

Unknown status·LLarissa University Hospital·N/A·NCT03596060·150 enrolled

Cesarean Section1 trial

Comparison of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia of Cesarean Section

Unknown status·TTao Zhang·Phase 4·NCT03149588·60 enrolled

Inflammation1 trial

Propofol and Perioperative Inflammation

Completed·UUniversity Hospital, Geneva·Phase 4·NCT01115179·79 enrolled

Arrhythmia1 trial

Effect of Sedative Agent on Reducing the Frequency of Arrhythmia in the Patients After Cardiac Surgery

Completed·AAnesthesia Research Group UA·N/A·NCT05450497·356 enrolled

Intravenous Lidocaine1 trial

Pilot Study of Effect of Intravenous Lidocaine on Propofol Requirement in Facial Plastic Surgery

Completed·—·Phase 4·NCT02597140·40 enrolled

Gastrointestinal1 trial

Laryngeal Mask in Upper Gastrointestinal Procedures

Terminated·OOspedale San Raffaele·N/A·NCT03567928·16 enrolled

Ventricular Tachycardia1 trial

Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia

Completed·—·N/A·NCT02419547·11 enrolled

Esketamine1 trial

Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine on Tussis Reflection During Upper Gastroscopy

Unknown status·—·N/A·NCT05497492·400 enrolled

Craniosynostosis1 trial

Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis

Enrolling by invitation·TTamas Vegh, MD·Phase 4·NCT07080528·20 enrolled

Headache1 trial

Propofol Injection for Daily Headache

Completed·UUniversity of Alberta·Phase 2·NCT00228267·28 enrolled

Opioid Consumption1 trial

Pupillometry Guided Remifentanil Administration and Total Opioid Consumption During Propofol - Remifentanil TCI

Completed·PPr Isabelle CONSTANT·N/A·NCT02576600·65 enrolled

Autism Spectrum Disorder1 trial

Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing Colonoscopy

Completed·TThe Second Hospital of Nanjing Medical University·N/A·NCT05951465·46 enrolled

Tics1 trial

Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses

Completed·PParc de Salut Mar·Phase 1/2·NCT03928366·30 enrolled

Prognosis1 trial

The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action

Recruiting·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT05663242·300 enrolled

Post Operative Cognitive Dysfunction1 trial

Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction

Completed·SSun Yat-sen University·Phase 4·NCT01809041·684 enrolled

Hemodynamic Response1 trial

Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery

Unknown status·KKorea University Anam Hospital·Phase 4·NCT02464722·50 enrolled

Laparotomy1 trial

Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Completed·—·Phase 4·NCT06772727·149 enrolled

Hysterectomy1 trial

Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy

Recruiting·TTanta University·N/A·NCT07062367·90 enrolled

Parkinson's Disease1 trial

Effects of Propofol on Brain Function in Patients With Parkinson's Disease

Recruiting·—··NCT05895019·600 enrolled

Nerve Block1 trial

Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT02740127·52 enrolled

Muscle Relaxants1 trial

The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)

Recruiting·—·N/A·NCT06707532·32 enrolled

Drug1 trial

Modeling and Application of Triple Drug Response Surface Models

Completed·TTaipei Veterans General Hospital, Taiwan··NCT03813875·100 enrolled

Oocyte Retrieval1 trial

Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization

Terminated·UUniversity of South Florida·Phase 4·NCT03732469·4 enrolled

Renal Transplantation1 trial

Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation

Completed·YYonsei University·Phase 4·NCT01132157·99 enrolled

Hemodynamic1 trial

Compare Hemodynamic Parameters of Propofol and Sevoflurane During CPB Time in Undergoing CABG to Avoid Lactate Level

Unknown status·—·N/A·NCT05004545·126 enrolled

Prostatectomy1 trial

Analysis of Change of Optic Nerve Sheath Diameter in Robot Assisted Laparoscopic Radical Prostatectomy

Completed·SSeoul National University Hospital·N/A·NCT03152981·60 enrolled

Craniotomy1 trial

Desflurane and Brain Relaxation in Craniotomy

Completed·—·N/A·NCT04691128·111 enrolled

Cholangitis1 trial

Ketofol Versus Propofol in Urgent ERCP for Acute Cholangitis

Unknown status·—·Phase 4·NCT04997967·100 enrolled

Sleep Disorder1 trial

DISE in Pediatric Sleep Disordered Breathing

Withdrawn·UUniversity of Iowa·Phase 2/3·NCT06756971

Endoscopy1 trial

A Comparison of Injection Pain of Propofol During Endoscopy : LCT Propofol vs MCT/LCT Propofol

Completed·KKyungpook National University Hospital·Phase 4·NCT02567916·129 enrolled

Post-Traumatic Stress Disorder, PTSD1 trial

Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy

Unknown status·SSouthern California Institute for Research and Education·Phase 1·NCT01736020·293 enrolled

Respiratory Depression1 trial

Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care

Completed·—·Phase 4·NCT07076628·76 enrolled

Third Molar Surgery1 trial

Effect of Total Intravenous Anaesthesia With Propofol on Postoperative Pain After Bilateral Third Molar Surgery

Completed·TThe University of Hong Kong·Phase 4·NCT03058341·96 enrolled

Cataract1 trial

Conscious Sedation for Cataract Operations Under Topical Anaesthesia

Completed·MMenoufia University·Phase 2·NCT03933280·100 enrolled

Migraine1 trial

Low-dose Propofol for Pediatric Migraine

Completed·OOregon Health and Science University·Phase 2/3·NCT01604785·74 enrolled

Outcome1 trial

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial

Terminated·PPeter MacCallum Cancer Centre, Australia·Phase 3·NCT04316013·254 enrolled

Depression1 trial

Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II

Recruiting·WWashington University School of Medicine·Phase 2·NCT06867549·70 enrolled

Adenoma1 trial

Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection

Completed·—·N/A·NCT05088252·112 enrolled

Loss of consciousness1 trial

The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness

Unknown status·SShanghai Zhongshan Hospital··NCT03762538·100 enrolled

Aneurysm1 trial

The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.

Terminated·JJohns Hopkins University·N/A·NCT01772537·14 enrolled

Ketamine1 trial

Comparison of Propofol/Alfentanil With Propofol/Ketamine

Unknown status·RRabin Medical Center·N/A·NCT02000206·80 enrolled

Analgesia1 trial

The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery

Unknown status·SSecond Affiliated Hospital of Xi'an Jiaotong University·Phase 4·NCT02503826·60 enrolled

Lung Cancer1 trial

Anesthesia in Flexible Bronchoscopy for Lung Cancer Diagnostic

Completed·—·Phase 4·NCT00440960

Knee Surgery1 trial

Music Distraction and Its Influence on Anesthetic Requirements During Elective Knee Surgery

Completed·VVirginia Commonwealth University·N/A·NCT03486106·36 enrolled

Ventilation1 trial

Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT00741949·46 enrolled

Epilepsy1 trial

Conscious Sedation for Epilepsy Surgery

Completed·MMenoufia University·N/A·NCT02988050·60 enrolled

Circadian Rhythm1 trial

Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children

Unknown status·DDu yi·Phase 4·NCT02013986·30 enrolled

Erector Spinae Block1 trial

Ultrasound Guided Erector Spinae Block vs Thoracolumbar Interfascial Plane Block

Completed·TTanta University·N/A·NCT05596227·180 enrolled

Fatigue1 trial

Postoperative Fatigue and Nausea Related to Choice of Anaesthetic Regimens

Completed·SSykehuset Telemark·Phase 4·NCT01125982·130 enrolled

Brain Injury1 trial

Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

Completed·UUnknown Sponsor·Phase 1/2·NCT00538616·8 enrolled

Hemolysis1 trial

Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty

Unknown status·CCentro Medico Campinas·N/A·NCT00792779·60 enrolled

Efficacy1 trial

A Study Evaluating Tolerability, Efficacy, and Safety of HSK3486 Injectable Emulsion in Patients

Completed·SSichuan Haisco Pharmaceutical Group Co., Ltd·Phase 2·NCT03773042·64 enrolled

General Anaesthesia1 trial

Study to Evaluate the Optimal Dose of Remifentanil During MRI of the Heart Under General Anaesthesia

Unknown status·AAlder Hey Children's NHS Foundation Trust·Phase 3·NCT02481791·35 enrolled

Suprascapular Nerve Block1 trial

Postoperative Analgesia of Magnesium Sulfate in Suprascapular Nerve Block Following Shoulder Arthroscopy

Unknown status·MMansoura University·N/A·NCT03602469·60 enrolled

Hypersensitivity1 trial

Hypersensitivity Reactions to Propofol in Children

Completed·UUniversitair Ziekenhuis Brussel··NCT04839666·2,299 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation

Terminated·UUniversity Hospital, Montpellier·N/A·NCT03460015·16 enrolled

Geriatric Patients1 trial

Propofol Dose-Finding for Colonoscope Insertion in Geriatric Patients

Completed·—·N/A·NCT07162805·29 enrolled

One-lung Ventilation1 trial

Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Active, not recruiting·JJuntendo University·N/A·NCT02324283·80 enrolled

Splenectomy1 trial

Effects of Desflurane Versus Propofol on Hemostasis During Splenectomy

Completed·TTheodor Bilharz Research Institute·N/A·NCT02079064·30 enrolled

Aortic Valve Replacement1 trial

Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults

Completed·—·Phase 3·NCT05696509·75 enrolled

Memory1 trial

Memory & Conditioning Under Anesthesia

Completed·KKeith M Vogt·Phase 1·NCT04062123·92 enrolled

Cerebral Palsy1 trial

Optimal Dose of Propofol for Induction of Deep Sedation for Brain MRI Scanning in Children With Cerebral Palsy

Completed·YYonsei University·N/A·NCT01244113·20 enrolled

Female1 trial

Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects.

Completed·SSichuan Haisco Pharmaceutical Group Co., Ltd·Phase 1·NCT04037657·25 enrolled

Epidural Block1 trial

Horner's SD After Thoracic Epidural Block

Completed·SSoonchunhyang University Hospital··NCT02130739·450 enrolled

Bladder Cancer1 trial

Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

Recruiting·PPeking University First Hospital·Phase 4·NCT04532606·1,128 enrolled

Postoperative Analgesia1 trial

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

Acetaminophen1 trial

Analgesic Effect of IV Acetaminophen in Tonsillectomies

Completed·NNationwide Children's Hospital·Phase 2·NCT01691690·250 enrolled

Subarachnoid Hemorrhage1 trial

Effects of Dexmedetomidine on Inflammatory Cytokines in Patients With Aneurysmal Subarachnoid Hemorrhage

Terminated·UUniversity of Cincinnati·Phase 3·NCT01565590·4 enrolled

Trial1 trial

The PATHFINDER Study: A Feasibility Trial

Completed·—·Phase 1·NCT04016740·22 enrolled

Hernia1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Unknown status·—·N/A·NCT03041948·88 enrolled

Respiratory Distress Syndrome (RDS)1 trial

Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS)

Unknown status·FFederal University of Minas Gerais·Phase 4·NCT00797160·20 enrolled

Stroke1 trial

Helping Stroke Patients With ThermoSuit Cooling

Terminated·LLife Recovery Systems·N/A·NCT02453373·14 enrolled

Children1 trial

Namsos Anaesthesia Children Outcome Study

Completed·HHelse Nord-Trøndelag HF·N/A·NCT04292457·761 enrolled

Mastectomy1 trial

Ultrasound-guided Paravertebral Block Versus Mid-point Transverse Process Pleura Block in Mastectomy Surgery

Completed·—·Phase 4·NCT05332028·64 enrolled

Mechanically Ventilated Patients1 trial

Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam

Withdrawn·VVirginia Commonwealth University·Phase 4·NCT00871039

Dexmedetomidine1 trial

Effect of Dexmedetomidine on Propofol Requirement During Anesthesia

Completed·DDr Nitin Sethi·Phase 4·NCT02599168·80 enrolled

Supratentorial Brain Tumor1 trial

Assessment of Cognitive Functions and Quality of Life in Patients Undergoing Surgery for Supratentorial Brain Tumor

Unknown status·—·N/A·NCT02428972·30 enrolled

Unspecified2 trials

Effect of Bispectral Index Monitoring (BIS) on Body Movement of Outpatients Undergoing Gastroscopy

Completed·WWest China Hospital·N/A·NCT05773807·400 enrolled

A Study of Human Multi-Sensory Integration

Suspended·UUniversity of Pennsylvania·Phase 2·NCT03498391·40 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 2, 1989

DIPRIVAN

NDA NDA019627

Sources

References

[1]
ClinicalTrials.gov — 917 trial records for Propofol. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Diprivan drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Propofol compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Propofol. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA019627). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Fresenius Kabi Oncology Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: GABA-a Receptor; Anion Channel Positive Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: FFresenius Kabi Oncology Ltd.

Diprivan

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Sedation23 trials

Delirium9 trials

Propofol6 trials

Anesthesia6 trials

Sevoflurane6 trials

Agitation5 trials

Efficacy and Safety5 trials

Remimazolam4 trials

Total Intravenous Anesthesia4 trials

General Anesthetics3 trials

Bronchoscopy3 trials

Intraoperative3 trials

Hemodynamic Stability3 trials

Oxidative Stress2 trials

Elderly Patients2 trials

Tracheal Intubation2 trials

Colonoscopy2 trials

Post Operative Pain2 trials

Nausea and vomiting2 trials

Acute Respiratory Distress Syndrome2 trials

Pediatric2 trials

Hypotension2 trials

Intensive Care Unit2 trials

Concentration2 trials

Anesthesia Induction2 trials

General Anesthesia2 trials

Open Heart Surgery2 trials

Aesthetic2 trials

Glioma1 trial

Shoulder Arthroplasty1 trial

Coronary Artery Bypass1 trial

Central Nervous System1 trial

Atrial Fibrillation1 trial

Breast Surgery1 trial

PONV1 trial

Seizure1 trial

Botulinum Toxin1 trial

Midazolam1 trial

Cognitive Functions1 trial

Hip Fracture1 trial

Cesarean Section1 trial

Inflammation1 trial

Arrhythmia1 trial

Intravenous Lidocaine1 trial

Gastrointestinal1 trial

Ventricular Tachycardia1 trial

Esketamine1 trial

Craniosynostosis1 trial

Headache1 trial

Opioid Consumption1 trial

Autism Spectrum Disorder1 trial

Tics1 trial

Prognosis1 trial

Post Operative Cognitive Dysfunction1 trial

Hemodynamic Response1 trial

Laparotomy1 trial

Hysterectomy1 trial

Parkinson's Disease1 trial

Nerve Block1 trial

Muscle Relaxants1 trial

Drug1 trial

Oocyte Retrieval1 trial

Renal Transplantation1 trial

Hemodynamic1 trial

Prostatectomy1 trial

Craniotomy1 trial

Cholangitis1 trial

Sleep Disorder1 trial

Endoscopy1 trial

Post-Traumatic Stress Disorder, PTSD1 trial

Respiratory Depression1 trial

Third Molar Surgery1 trial

Cataract1 trial