Diprivan

(Propofol)

ApprovedSmall molecule

Propofol is used to put patients to sleep before surgery and medical procedures, and to keep them sedated while on a ventilator in the hospital. It works quickly to make someone unconscious and is commonly used by anesthesiologists.[2] Diprivan is currently approved and in use across 158 indications[4].[1]

Diprivan is one of 1744 small molecule programs targeting Sedation. It is currently in Approved.

158

Indications

941

Total Trials

Active Trials

1,743

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Chronic Kidney DiseaseApproved

Depressive DisorderApproved

Septic ShockApproved

Respiratory InsufficiencyApproved

PolypApproved

Cognitive ImpairmentApproved

Migraine DisorderApproved

Cirrhosis of LiverApproved

StrabismusApproved

TonsillitisApproved

Chronic Kidney DiseaseApproved

Approved

Depressive DisorderApproved

Approved

Septic ShockApproved

Approved

Respiratory InsufficiencyApproved

Approved

PolypApproved

Approved

Cognitive ImpairmentApproved

Approved

Migraine DisorderApproved

Approved

Cirrhosis of LiverApproved

Approved

StrabismusApproved

Approved

TonsillitisApproved

Approved

Showing 10 of 148 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Diprivan

FFresenius Kabi USA, LLC

Approved

2 2

Voltaren

Novartis

Preclinical

1 3

Zolymbus

AbbVie

Preclinical

1 4

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 5

Duragesic-100

CCephalon

Preclinical

2 6

Spravato

WWim Janssens

Preclinical

2 7

Acupan

YYonsei University

Preclinical

1 8

Chantix

PPrism Pharmaceuticals

Preclinical

1 9

Nubain

AAultman Health Foundation

Preclinical

1 10

Feraheme

AAzurity Pharmaceuticals

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Recruiting

Parkinson's Disease

NCT05895019

Q4 2026

N/ANot yet recruiting

Coronary Artery Bypass

NCT06496165

Q1 2027

Post-ApprovalNot yet recruiting

Pruritus

NCT06715657

N/ARecruiting

Hysterectomy

NCT07062367

Q3 2027

Phase 2Recruiting

Cardiac Arrest

NCT06744361

N/ANot yet recruiting

Gynecologic Surgery

NCT07251101

Clinical

Trials by Indication[1]

Sedation26 trials

Paradoxical Excitement Response During Sedation Between Dexmedetomidine and Propofol in Hazardous Alcohol Drinker

Unknown status·—·Phase 4·NCT02197403·110 enrolled

Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)

Completed·HHennepin Healthcare Research Institute·Phase 4·NCT00997321·100 enrolled

Intravenous Propofol and Fentanyl vs Propofol for Sedation in TRUS Biopsy

Completed·MMahidol University·Phase 4·NCT02733705·124 enrolled

Show 23 more trials

The Influence of Sedation for Endoscopy on Cognitive Function

Terminated·SShanghai Jiao Tong University School of Medicine··NCT04168294·200 enrolled

Combined Ketamine/Propofol for Emergency Department Procedural Sedation

Terminated·UUniversity of Missouri-Columbia·N/A·NCT01126957·107 enrolled

Dexmedetomidine Versus Propofol for Continuous Sedation in the Intensive Care Unit (ICU)

Completed· Orion Corporation, Orion Pharma logo

Orion Corporation, Orion Pharma·Phase 3·NCT00479661·500 enrolled

A Low Dose Dexmedetomidine in Sedation Colonoscopy

Unknown status·WWest China Hospital·N/A·NCT06208956·104 enrolled

Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy

Suspended·RRabin Medical Center·N/A·NCT02743104·150 enrolled

Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy

Completed·IInfante, Javier Molina, M.D.·Phase 4·NCT01428882·135 enrolled

Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia

Completed·—·N/A·NCT02502877·27 enrolled

Sedation for Patients Undergoing Endoscopic Retrograde Cholangiopancreatography

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04860167·90 enrolled

EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation

Withdrawn·MMassachusetts General Hospital·Phase 1/2·NCT03610282

Comparison of Hemodynamics Between Dexmedetomidine and Propofol for Sedation in Patients With Abdominal Surgery

Completed·NNational Taiwan University Hospital·Phase 4·NCT02393066·60 enrolled

Arousal Pathways and Emergence From Sedation

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT02253758·20 enrolled

Sedation Strategies for Diagnostic Bronchoscopy

Terminated·—·N/A·NCT03406533·28 enrolled

Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine.

Completed·PPrince of Songkla University·Phase 4·NCT01709422·140 enrolled

Sedation Strategies for Diagnostic Bronchoscopy 2

Unknown status·—·N/A·NCT03983889·200 enrolled

Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Implantation

Completed·UUniversity Medical Centre Ljubljana·Phase 4·NCT03747432·70 enrolled

The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

Recruiting·SSiriraj Hospital·N/A·NCT06203405·214 enrolled

A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial

Completed·YYonsei University·Phase 4·NCT01895348·60 enrolled

RCT of Efficacy and Safety of Sedation Compared to General Anesthesia for ERCP

Terminated·EErasme University Hospital·N/A·NCT02046590·120 enrolled

Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup

Recruiting·WWunschbaby Institut Feichtinger·N/A·NCT05741814·100 enrolled

Balanced Propofol Sedation Versus Propofol Alone Sedation in Therapeutic Endoscopic Retrograde Cholangiopancreatography (ERCP)

Unknown status·SSoon Chun Hyang University·Phase 4·NCT01321047·204 enrolled

A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy

Recruiting·—·Phase 4·NCT07456111·90 enrolled

A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation

Completed· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 2·NCT04669821·20 enrolled

The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy

Completed·UUfuk University·Phase 4·NCT02486328·103 enrolled

Propofol9 trials

Effects of Propofol on Early Recovery of Hunger After Surgery

Completed·UUniversity Hospital, Rouen·Phase 4·NCT02272166·116 enrolled

Onset Time of Thiopental Versus Propofol in the Elderly

Completed·RRigshospitalet, Denmark·Phase 4·NCT00965107·78 enrolled

The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats

Completed·UUniversity of British Columbia·N/A·NCT00358618·60 enrolled

Show 6 more trials

Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive Therapy

Completed·—·N/A·NCT07273851·80 enrolled

Validation Study of Covariates Model (VaSCoM) for Propofol

Completed·GGolden Jubilee National Hospital·N/A·NCT01492712·40 enrolled

Therapeutic Equivalence (TE) Study of Propofol 2% MCT Fresenius (MCT=Medium-Chain Triglycerides) Compared With Diprivan® in Patients Undergoing Elective Surgery

Completed·FFresenius·Phase 3·NCT01856998·71 enrolled

A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects

Completed·SStanford University·Phase 1·NCT01591148·30 enrolled

Propofol Pharmacokinetics and Pharmacodynamics Modelling

Completed·—··NCT02713698·60 enrolled

A Study to Assess the Transfer of Fospropofol and Its Active Metabolite, Propofol, to Breast Milk Following Administration of LUSEDRA to Lactating Women Undergoing a Needed Procedure

Completed· Eisai logo

Eisai·Phase 1·NCT01309984·10 enrolled

Delirium6 trials

Influence of Dexmedetomidine or Propofol on ICU Delirium

Terminated·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT02807467·37 enrolled

Reducing Delirium After Cardiac Surgery: A Multifaceted Approach Of Perioperative Care

Completed·UUniversity Health Network, Toronto·N/A·NCT01378741·185 enrolled

Sevoflurane and Propofol Anesthesia on Postoperative Delirium

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT01995214·500 enrolled

Show 3 more trials

Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.

Completed·TThe First Affiliated Hospital of Anhui Medical University·N/A·NCT02793986·296 enrolled

Decreasing the Incidence of Delirium After Cardiac Surgery

Withdrawn·UUniversity of California, Los Angeles·Phase 4·NCT02119806

Effect of Remimazolam and Propofol on Postoperative Delirium

Recruiting·IInje University·N/A·NCT05514405·82 enrolled

Anesthesia6 trials

The Effect of Different End-tidal Carbon-dioxide Levels on Cerebral CO2 Vasoreactivity and the Stiffness of Systemic Arteries During Propofol Anesthesia

Completed·UUniversity of Debrecen·Phase 4·NCT02203097·25 enrolled

Evaluation of Different Anesthesia for Uterine Curettage

Completed·NNanjing Medical University·N/A·NCT00733564·150 enrolled

Different Anesthesia Maintain Protocol Effect the Outcome of the Patients

Completed·CChina International Neuroscience Institution·Phase 4·NCT04443946·50 enrolled

Show 3 more trials

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

Completed·UUniversity of Turku·Phase 4·NCT02624401·160 enrolled

EEG Studies of IV Methylphenidate-Induced Emergence From Anesthesia

Withdrawn·MMassachusetts General Hospital·Phase 1/2·NCT02429076

Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI

Terminated·SState University of New York at Buffalo·Phase 4·NCT02111447·6 enrolled

Total Intravenous Anesthesia5 trials

Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery

Completed·TTaichung Veterans General Hospital·N/A·NCT03263078·78 enrolled

Comparison of Optic Nerve Sheath Diameter in Children Receiving Caudal Block According to Anesthetic Agents: Total Intravenous Anesthesia vs. Volatile Anesthesia

Completed·YYonsei University·N/A·NCT04415905·60 enrolled

The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery

Completed·AAilin Luo·N/A·NCT05810363·468 enrolled

Show 2 more trials

Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block

Completed·MMaimonides Medical Center·Phase 4·NCT02469961·50 enrolled

Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Completed·MMedical University Innsbruck·Phase 4·NCT00706277·60 enrolled

109 more indications

Sevoflurane4 trials

Does Sevoflurane Cause Genomic Damage

Unknown status·JJubilee Mission Medical College and Research Institute·Phase 4·NCT03109119·30 enrolled

Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells

Active, not recruiting·SSaint Petersburg State University, Russia·Phase 1·NCT06626711·10 enrolled

Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation

Completed·—·Phase 3·NCT05615025·48 enrolled

Show 1 more trial

Propofol or Sevoflurane Anesthesia in Egyptian Patients

Completed·RRehab Werida·N/A·NCT05289349·44 enrolled

Agitation4 trials

Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation

Completed·—·Phase 4·NCT06312618·80 enrolled

Effect of Rematazolam Besylate, Propofol, and Sevoflurane Perioperative Sedation on Incidence of Emergence Agitation and Hemodynamics in Patients Undergoing Laparoscopic Abdominal Surgery

Unknown status·SSecond Affiliated Hospital of Nanchang University·Phase 4·NCT05624424·1,317 enrolled

Propofol in Emergence Agitation

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT00535613·99 enrolled

Show 1 more trial

The Effect of Propofol Versus Lidocaine on Emergence Agitation in Children Undergoing Tonsillectomy.

Not yet recruiting·—·Phase 4·NCT07268924·82 enrolled

Anesthesia Induction3 trials

Left Ventricular Diastolic Function During Anesthesia Induction

Completed·UUniversitätsklinikum Hamburg-Eppendorf··NCT03522194·200 enrolled

Remimazolam Versus Propofol for General Anesthesia Induction in Patients on Renin-angiotensin System Blockers Undergoing Robot-assisted Laparoscopic Prostatectomy

Completed·YYonsei University·N/A·NCT06093971·112 enrolled

EEG-fMRI Experiments During Anesthesia Induction With Propofol

Recruiting·TTechnical University of Munich·N/A·NCT06179719·35 enrolled

General Anesthesia3 trials

Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol

Completed·SSeoul National University Hospital·N/A·NCT05435911·66 enrolled

A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 3·NCT03921775·330 enrolled

The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function

Not yet recruiting·TThe Second Affiliated Hospital of Chongqing Medical University·N/A·NCT06775366·174 enrolled

Intensive Care Unit3 trials

Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects

Completed· GSK logo

GSK·Phase 4·NCT00158873·224 enrolled

Comparison Between Dexmedetomidine and Propofol for Patients in the Intensive Care Unit After Abdominal Surgery

Completed·NNational Taiwan University Hospital·Phase 4·NCT02874768·60 enrolled

Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)

Terminated·UUniversity of Chicago·Phase 4·NCT01059929·41 enrolled

Efficacy and Safety3 trials

A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery

Completed· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 3·NCT06391931·190 enrolled

A Phase IIa Study Investigating the Tolerance, Efficacy and Safety of HSK3486

Completed·SSichuan Haisco Pharmaceutical Group Co., Ltd·Phase 2·NCT03698617·114 enrolled

A Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion for the Induction of General Anesthesia in Elective Surgery Subjects

Completed·SSichuan Haisco Pharmaceutical Group Co., Ltd·Phase 3·NCT03808844·178 enrolled

Oxidative Stress3 trials

The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

Completed·YYonsei University·Phase 4·NCT02149628·50 enrolled

Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy

Completed·RRennes University Hospital·Phase 3·NCT00219856·34 enrolled

Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Unknown status·ZZhujiang Hospital·Phase 4·NCT02202239·60 enrolled

Bronchoscopy3 trials

Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy

Completed·—·Phase 4·NCT01470170·173 enrolled

QT Distance and P Dispersion in ECG in Patients Having Bronchoscopy in the ICU

Unknown status·—·N/A·NCT05434624·40 enrolled

Remifentanil Use in Pediatric Rigid Bronchoscopy

Completed·—·Phase 4·NCT01947114·40 enrolled

Memory3 trials

Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive Patients

Unknown status·FFirst Affiliated Hospital of Chongqing Medical University·Phase 1·NCT05266560·390 enrolled

Memory & Conditioning Under Anesthesia

Completed·KKeith M Vogt·Phase 1·NCT04062123·92 enrolled

Memory Priming in General Anesthesia

Completed·FFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta·N/A·NCT03727464·102 enrolled

Nausea and vomiting3 trials

Propofol Versus Dexmedetomidine on the Incidence of Postoperative Nausea and Vomiting

Unknown status·—·N/A·NCT05875077·45 enrolled

The Preventive Effects of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate

Completed·WWest China Second University Hospital·Phase 4·NCT03185156·60 enrolled

Effect of Propofol on Postoperative Nausea and Vomiting.

Completed·PPakistan Air Force (PAF) Hospital Islamabad·Phase 4·NCT05071794·60 enrolled

Tracheal Intubation3 trials

Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction

Completed·UUniversity of Virginia·Phase 4·NCT01150838·106 enrolled

Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation

Terminated·EErasmus Medical Center·Phase 1·NCT02040909·91 enrolled

Ciprofol Versus Propofol for Tracheal Intubation in ICU

Completed·SShanghai Zhongshan Hospital·Phase 4·NCT06344949·100 enrolled

Atrial Fibrillation2 trials

Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

Completed·MMedical University of South Carolina·N/A·NCT02697448·135 enrolled

Comparison of Remimazolam With Flumazenil vs. Propofol During RFCA for Atrial Fibrillation

Completed·SSeoul National University Hospital·N/A·NCT05397886·54 enrolled

Concentration2 trials

A Pilot Study to Investigate Plasma Bupivacaine Concentrations in Children Receiving Total Intravenous Anaesthesia and Caudal Analgesia

Completed·UUniversity of British Columbia·Phase 1/2·NCT01216007·30 enrolled

Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

Withdrawn·—·Phase 4·NCT03283410

Post Operative Cognitive Dysfunction2 trials

The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients

Completed·—·N/A·NCT06353516·154 enrolled

Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction

Completed·SSun Yat-sen University·Phase 4·NCT01809041·684 enrolled

Obese Patients2 trials

Optimizing Propofol in Obese Patients

Completed·RRigshospitalet, Denmark·Phase 4·NCT00270335·38 enrolled

Preoxygenation With Optiflow™ in Morbidly Obese Patients is Superior to Face Mask

Withdrawn·MMontefiore Medical Center·N/A·NCT03009877

Subarachnoid Hemorrhage2 trials

Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation

Completed·AAzienda Ospedaliera San Gerardo di Monza·Phase 4·NCT00830843·13 enrolled

Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage

Withdrawn·—·Phase 2/3·NCT05032118

Metabolism2 trials

Cerebral Flow-metabolism Coupling During Adult Surgery

Unknown status·JJason Chui·Phase 4·NCT05941494·80 enrolled

Identification of Polymorphisms Involved in the Metabolism of Propofol

Completed·TTC Erciyes University·Phase 4·NCT02271542·300 enrolled

Coronary Artery Bypass2 trials

Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane

Completed·UUniversity of Melbourne·N/A·NCT00400790·182 enrolled

Remimazolam Besylate and Propofol Sedation on Hemodynamic for Coronary Artery Bypass Graft Patients

Not yet recruiting·SShanghai Zhongshan Hospital·N/A·NCT06496165·338 enrolled

Hip Fracture2 trials

Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients

Completed·YYonsei University·N/A·NCT02458547·186 enrolled

Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel

Unknown status·LLarissa University Hospital·N/A·NCT03596060·150 enrolled

Gynecologic Surgery2 trials

Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery

Not yet recruiting·IIlsan Cha hospital·N/A·NCT07251101·58 enrolled

Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Laparoscopic Gynecologic Surgery

Unknown status·OObstetrics & Gynecology Hospital of Fudan University·Phase 1·NCT03498235·110 enrolled

Dexmedetomidine2 trials

Effects of Dexmedetomidine and Propofol on Pulmonary Mechanics

Completed·—·Phase 4·NCT02330120·64 enrolled

Propofol and Dexmedetomidine on Inflammation

Unknown status·TThe First Affiliated Hospital of Anhui Medical University·N/A·NCT03600727·200 enrolled

Colonoscopy2 trials

Inhaled Sevofluran vs Endovenous Propofol for Colonoscopy

Completed·CCentro Medico Docente la Trinidad·N/A·NCT03818048·32 enrolled

Explore the Clinical Application Value of Ciprofol in Painless Colonoscopy

Completed·SSichuan Provincial People's Hospital·N/A·NCT05294679·110 enrolled

Intraoperative2 trials

UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT03284307·35 enrolled

Intraoperative Sedatives and Postoperative Deilirium

Completed·SSeoul National University Bundang Hospital·N/A·NCT03251651·748 enrolled

Postoperative Analgesia2 trials

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT03135795·100 enrolled

Cataract2 trials

Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia

Completed·FFondation Ophtalmologique Adolphe de Rothschild·Phase 4·NCT02771912·60 enrolled

Dexmedetomidine vs. Propofol for Cataract Surgery

Completed·TThe Cooper Health System·Phase 4·NCT00786370·24 enrolled

Hemodynamic Stability1 trial

Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia

Withdrawn·YYale University·Phase 2·NCT02282891

Digestive Cancer1 trial

Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery

Unknown status·IIuliu Hatieganu University of Medicine and Pharmacy·Phase 1·NCT04162535·40 enrolled

Mortality1 trial

Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery

Completed·UUniversity of Zurich·Phase 4·NCT01452256·460 enrolled

Intravenous Anesthesia1 trial

Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study

Recruiting·UUniversity of Kansas Medical Center·Phase 2·NCT06017141·80 enrolled

Brain Injury1 trial

Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

Completed·UUnknown Sponsor·Phase 1/2·NCT00538616·8 enrolled

Scoliosis1 trial

Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients

Completed·NNationwide Children's Hospital·N/A·NCT01549873·30 enrolled

Surgery1 trial

Etomidate Induction in Hysteroscopic Surgery

Unknown status·PPeking University Third Hospital·N/A·NCT05520645·200 enrolled

Renal Transplantation1 trial

Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT00337051·120 enrolled

Hypotensive Anesthesia1 trial

Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation

Unknown status·MMansoura University·N/A·NCT05241054·64 enrolled

Pediatric Anesthesia1 trial

Recovery of TIVA vs Inhalation in Pediatric Anesthesia

Unknown status·—··NCT06215833·120 enrolled

Bariatric Surgery1 trial

Automated Closed Loop Propofol Anaesthesia Versus Desflurane Inhalation Anaesthesia In Bariatric Surgery

Completed·DDr Nitin Sethi·Phase 4·NCT03099616·40 enrolled

Pruritus1 trial

Effect of Propofol Administration Time on the Incidence and Severity of Intrathecal Morphine-induced Pruritus in Parturient Undergoing Elective Cesarean Delivaries

Not yet recruiting·—·Phase 4·NCT06715657·204 enrolled

Nitric Oxide1 trial

The Effects of Propofol and Thiopental on Nitric Oxide Production and Release in Erythrocytes

Completed·MMelike Cengiz·N/A·NCT06485388·12 enrolled

Cancer1 trial

Anesthetic Effect on Immune Cell in Patients With Cancer

Completed·KKonkuk University Medical Center·N/A·NCT02758249·47 enrolled

Dysphagia1 trial

Trial- Dysphagia From ETT or GI Endoscopy

Withdrawn·—·N/A·NCT02460055

Rocuronium1 trial

The Onset Time of Rocuronium in Emergency and Elective Surgery

Unknown status·—·Phase 3·NCT02634255·50 enrolled

Hemodynamic1 trial

Effect of Remazolam on Hemodynamics During Hepatectomy

Completed·JJun Zhang·Phase 4·NCT06565715·70 enrolled

Cardiac Arrest1 trial

Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest

Recruiting·CChristian Hassager·Phase 2·NCT06744361·282 enrolled

Patient Satisfaction1 trial

Patient Satisfaction With Propofol for Out Patient Colonoscopy

Completed·MMount Carmel Health System·Phase 4·NCT02937506·600 enrolled

Hematoma1 trial

Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia in Acute Subdural Hematoma Patients

Completed·JJawaharlal Institute of Postgraduate Medical Education & Research·Phase 4·NCT03146104·90 enrolled

Drug1 trial

Modeling and Application of Triple Drug Response Surface Models

Completed·TTaipei Veterans General Hospital, Taiwan··NCT03813875·100 enrolled

Carotid Endarterectomy1 trial

Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy

Completed·—·Phase 4·NCT02609087·69 enrolled

Regional Anesthesia1 trial

Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction

Completed·VVanderbilt University Medical Center·N/A·NCT02584452·59 enrolled

Laryngeal Mask Airway1 trial

Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia

Completed·RRWTH Aachen University·Phase 3·NCT02322502·352 enrolled

Liver1 trial

Intra-carotid Anesthetic Agent Delivery

Unknown status·MMansoura University·N/A·NCT02531477·5 enrolled

Acute Kidney Injury1 trial

Anesthesia and Acute Kidney Injury After Nephrectomy

Completed·SSeoul National University Hospital·N/A·NCT04474600·324 enrolled

Abortion1 trial

Remimazolam Versus Propofol for Painless Abortion

Completed·MMaternal and Child Health Hospital of Hubei Province·Phase 2·NCT05635955·100 enrolled

Remifentanil1 trial

Automatic Remifentanil Administration Guided by ANI During Propofol Anesthesia

Completed·UUniversity Hospital, Lille·N/A·NCT03556696·52 enrolled

Function1 trial

The Effects of Different Anesthetics on Functional Connectivity

Recruiting·—·N/A·NCT03343873·240 enrolled

Randomized1 trial

Propofol TCI Administered by Gastroenterologists During Endoscopy: a Randomized Double Blind Controlled Study

Completed·OOspedale San Raffaele·Phase 4·NCT01941888·140 enrolled

Invasive Procedure1 trial

Use of Lipid Emulsion or Nanoemulsion of Propofol on Children Undergoing Ambulatory Invasive Procedures.

Withdrawn·CCristália Produtos Químicos Farmacêuticos Ltda.·Phase 2/3·NCT01326078

Intravenous1 trial

The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep

Completed·YYanchao Yang·N/A·NCT04123249·74 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Maintenance of Etomidate in General Anesthesia

Completed·HHenan Provincial People's Hospital·Phase 4·NCT05223907·1,080 enrolled

Magnesium Sulfate1 trial

Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery

Unknown status·MMansoura University·N/A·NCT04078659·50 enrolled

Opioid Use Disorder1 trial

PROUD Study - Preventing Opioid Use Disorders

Terminated·EEmory University·Phase 4·NCT04766996·57 enrolled

Laparoscopic Surgery1 trial

Laparoscopic Surgery and Abdominal Compliance

Unknown status·CCHU de Reims·Phase 4·NCT02816567·180 enrolled

Thoracic Surgery1 trial

Evaluation of Automated Propofol Delivery in Patients Undergoing Thoracic Surgery

Completed·DDr Nitin Sethi·Phase 4·NCT03307551·30 enrolled

Nerve Block1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Completed·—·N/A·NCT03041935·90 enrolled

Morphine Induced Pruritis1 trial

Propofol for Prophylaxis of Morphine Induced Pruritis in Caesarean Section

Unknown status·—·Phase 3·NCT06188546·200 enrolled

Treatment1 trial

Esmolol Pretreatment on Pain During Injection of Propofol

Completed·KKyungpook National University Hospital·N/A·NCT01885364·120 enrolled

Elderly Patients1 trial

Etomidate to Improve Outcome in Elderly Patients

Completed·ZZhihong LU·N/A·NCT02910206·1,917 enrolled

Remimazolam1 trial

Effect of Remimazolam on Motor Evoked Potential

Completed·KKorea University Guro Hospital·N/A·NCT05453955·20 enrolled

Cerebral Palsy1 trial

Optimal Dose of Propofol for Induction of Deep Sedation for Brain MRI Scanning in Children With Cerebral Palsy

Completed·YYonsei University·N/A·NCT01244113·20 enrolled

Trial1 trial

The PATHFINDER Study: A Feasibility Trial

Completed·—·Phase 1·NCT04016740·22 enrolled

Hernia1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Unknown status·—·N/A·NCT03041948·88 enrolled

Stroke1 trial

Helping Stroke Patients With ThermoSuit Cooling

Terminated·LLife Recovery Systems·N/A·NCT02453373·14 enrolled

Mastectomy1 trial

Ultrasound-guided Paravertebral Block Versus Mid-point Transverse Process Pleura Block in Mastectomy Surgery

Completed·—·Phase 4·NCT05332028·64 enrolled

Cognitive Function1 trial

Effect of Propfol Versus Sevoflurane on Auditory and Cognitive Function

Completed·—·Phase 4·NCT04874545·80 enrolled

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Children1 trial

Time to Peak Effect of Propofol in Children

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT03426462·48 enrolled

Ambulatory Surgery1 trial

Comparison of Desflurane Anesthesia Versus TIVA-TCI in Patients Undergoing Ophthalmic Ambulatory Surgery

Completed·XXiaoliang Gan·N/A·NCT02922660·209 enrolled

Muscle Relaxation1 trial

A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients

Completed·JJiangsu Nhwa Pharmaceutical Co., Ltd.·Phase 4·NCT02117401·1,152 enrolled

LAM1 trial

The Application of Remazolam in Gastroenteroscopy

Completed·YYangzhou University·N/A·NCT05357430·83 enrolled

Non-Small Cell Lung Cancer1 trial

Anesthesia and Non-small Cell Lung Cancer Recurrence

Not yet recruiting·SSamsung Medical Center·Phase 4·NCT06330038·5,384 enrolled

Cardiac Surgery1 trial

Pain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery

Unknown status·MMansoura University·N/A·NCT04945694·80 enrolled

Autonomic Nervous System1 trial

Comparison of the Effects of Dexmedetomidine and Propofol on the Cardiovascular Autonomic Nervous System During Spinal Anesthesia

Completed·—·N/A·NCT04142502·60 enrolled

Craniotomy Surgery1 trial

Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery

Completed·TThe Cooper Health System·Phase 3·NCT00848991·15 enrolled

Major Depressive Disorder1 trial

Ketamine Co-induction for Patients With Major Depressive Disorder

Unknown status·UUniversity of Saskatchewan·Phase 4·NCT03666494·50 enrolled

Mitochondrial Disease1 trial

Anesthesia in Patients With Mitochondrial Disease

Terminated·TThe University of Texas Health Science Center, Houston·N/A·NCT02053766·19 enrolled

Etomidate Combined With Propofol1 trial

The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries

Unknown status·HHenan Provincial People's Hospital·Phase 4·NCT02174120·120 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Shoulder Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT03540030·86 enrolled

Headache1 trial

Low- Dose Propofol Infusion as an Abortive Treatment for Migraine Headaches in Pediatric Patients

Completed·UUniversity of Texas Southwestern Medical Center·N/A·NCT02485418·40 enrolled

Central Nervous System1 trial

Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users

Completed·HHaisco-USA Pharmaceuticals, Inc.·Phase 1·NCT07404306·43 enrolled

Post Operative Pain1 trial

Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects

Withdrawn·TThe University of Hong Kong··NCT03058354

Breast Surgery1 trial

Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00542542·89 enrolled

Acute Respiratory Distress Syndrome1 trial

Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome

Recruiting·GGuy's and St Thomas' NHS Foundation Trust·Phase 2/3·NCT06014138·20 enrolled

Pediatric1 trial

Predictive Model in EEG for Induction and Emergence in Pediatric With Propofol

Terminated·VVictor Contreras, MSN··NCT03705338·1 enrolled

Seizure1 trial

Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity

Completed·AAzienda Sanitaria-Universitaria Integrata di Udine··NCT05103735·170 enrolled

Cognitive Functions1 trial

Cognitive Functions After TIVA With Dexmedetomidine

Completed·UUludag University·Phase 4·NCT02631135·40 enrolled

Cesarean Section1 trial

Comparison of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia of Cesarean Section

Unknown status·TTao Zhang·Phase 4·NCT03149588·60 enrolled

Inflammation1 trial

Propofol and Perioperative Inflammation

Completed·UUniversity Hospital, Geneva·Phase 4·NCT01115179·79 enrolled

General Anesthetics1 trial

General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia

Recruiting·PPeking University First Hospital··NCT05210764·366 enrolled

Ventricular Tachycardia1 trial

Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia

Completed·—·N/A·NCT02419547·11 enrolled

Esketamine1 trial

Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine on Tussis Reflection During Upper Gastroscopy

Unknown status·—·N/A·NCT05497492·400 enrolled

Hypotension1 trial

Ciprofol Titrated Induction in Reducing Post-induction Hypotension in Geriatric Patients

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·N/A·NCT06258967·160 enrolled

Tics1 trial

Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses

Completed·PParc de Salut Mar·Phase 1/2·NCT03928366·30 enrolled

Laparotomy1 trial

Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Completed·—·Phase 4·NCT06772727·149 enrolled

Hysterectomy1 trial

Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy

Recruiting·TTanta University·N/A·NCT07062367·90 enrolled

Parkinson's Disease1 trial

Effects of Propofol on Brain Function in Patients With Parkinson's Disease

Recruiting·—··NCT05895019·600 enrolled

Muscle Relaxants1 trial

The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)

Recruiting·—·N/A·NCT06707532·32 enrolled

Efficacy1 trial

A Study Evaluating Tolerability, Efficacy, and Safety of HSK3486 Injectable Emulsion in Patients

Completed·SSichuan Haisco Pharmaceutical Group Co., Ltd·Phase 2·NCT03773042·64 enrolled

Unspecified2 trials

Decreasing the Use of Unmodified Electroconvulsive Therapy (ECT) in an Indian Hospital

Completed·JJohns Hopkins University·N/A·NCT01526395·99 enrolled

Anesthetic Techniques in EP Patients

Terminated·UUniversity of California, Los Angeles·Phase 4·NCT02664922·35 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 2, 1989

DIPRIVAN

NDA NDA019627

Jan 18, 1991

DIPRIVAN

NDA NDA019627

Jan 18, 1991

DIPRIVAN

NDA NDA019627

Jan 18, 1991

DIPRIVAN

NDA NDA019627

Jan 18, 1991

DIPRIVAN

NDA NDA019627

Dec 31, 1991

DIPRIVAN

NDA NDA019627

Feb 25, 1992

DIPRIVAN

NDA NDA019627

Dec 11, 1992

DIPRIVAN

NDA NDA019627

Mar 8, 1993

DIPRIVAN

NDA NDA019627

Mar 9, 1993

DIPRIVAN

NDA NDA019627

Oct 26, 1993

DIPRIVAN

NDA NDA019627

Oct 26, 1993

DIPRIVAN

NDA NDA019627

May 6, 1994

DIPRIVAN

NDA NDA019627

May 9, 1994

DIPRIVAN

NDA NDA019627

Sep 7, 1994

DIPRIVAN

NDA NDA019627

Feb 24, 1995

DIPRIVAN

NDA NDA019627

Apr 21, 1995

DIPRIVAN

NDA NDA019627

Jul 31, 1995

DIPRIVAN

NDA NDA019627

Jun 11, 1996

DIPRIVAN

NDA NDA019627

Sep 11, 1997

DIPRIVAN

NDA NDA019627

Sep 29, 1998

DIPRIVAN

NDA NDA019627

Feb 4, 1999

DIPRIVAN

NDA NDA019627

Apr 29, 1999

DIPRIVAN

NDA NDA019627

Apr 29, 1999

DIPRIVAN

NDA NDA019627

Dec 7, 1999

DIPRIVAN

NDA NDA019627

Feb 7, 2000

DIPRIVAN

NDA NDA019627

Oct 27, 2000

DIPRIVAN

NDA NDA019627

Feb 23, 2001

DIPRIVAN

NDA NDA019627

Sep 3, 2002

DIPRIVAN

NDA NDA019627

Feb 8, 2007

DIPRIVAN

NDA NDA019627

Apr 14, 2008

DIPRIVAN

NDA NDA019627

Jul 9, 2013

DIPRIVAN

NDA NDA019627

May 5, 2014

DIPRIVAN

NDA NDA019627

Jun 8, 2014

DIPRIVAN

NDA NDA019627

Apr 17, 2015

DIPRIVAN

NDA NDA019627

Apr 27, 2017

DIPRIVAN

NDA NDA019627

May 11, 2021

DIPRIVAN

NDA NDA019627

Aug 31, 2022

DIPRIVAN

NDA NDA019627

Nov 21, 2025

DIPRIVAN

NDA NDA019627

Sources

References

[1]
ClinicalTrials.gov — 941 trial records for Propofol. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Diprivan drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Propofol compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Propofol. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA019627). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Fresenius Kabi USA, LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: GABA-a Receptor; Anion Channel Positive Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: FFresenius Kabi USA, LLC