VivoSeq
Other

Cleft Palate

17

Pipeline Programs↗

5

Active Trials↗

6

Companies Involved↗

Cleft Palate is an emerging landscape with 17 programs across 6 companies. The most active players are GSK, Purdue Pharma LP, Pacira Pharmaceuticals, Inc. 6 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

45/100

Pipeline Velocity

6/100

Mech. Concentration

33/100

Completion Rate

64/100

Attrition Rate

22/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

GSK logo

GSK

1 program

Phase 2P

Purdue Pharma LP

1 program

Phase 3Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc

1 program

Phase 3K

Kenvue Brands

1 program

ApprovedM

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

ApprovedLEO Pharma logo

LEO Pharma

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

18

clinical trials

Completed7 · 39%
Withdrawn4 · 22%
Recruiting3 · 17%
Unknown status2 · 11%
Active, not recruiting1 · 6%
Enrolling by invitation1 · 6%

Clinical Trials

Trial Activity

18 trials

Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft Palate
Recruiting·—·Phase 4·NCT05821972·60 enrolled
Nebulized Bupivacaine Analgesia for Cleft Palate Repair
Recruiting·—·Phase 3·NCT04928352·60 enrolled
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
Recruiting·—·Phase 4·NCT06962306·60 enrolled
Nalbuphine as Adjuvant During Bilateral Suprazygomatic Maxillary Nerve Block for Pediatric Cleft Palate Repair
Active, not recruiting·—·N/A·NCT06100315·60 enrolled
Exploring Speech Intervention Frameworks for Cantonese-speaking Children and Adolescents With Cleft Palate +/- Lip: A Randomized-Controlled Trial
Enrolling by invitation·CChinese University of Hong Kong·Preclinical·NCT07692061·12 enrolled
Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery
Completed·—·Phase 2/3·NCT02923869·60 enrolled
Preventing Complications in Cleft Palate Repair With Antibiotics
Completed·—·Phase 2·NCT00760006·224 enrolled
A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis
Completed·LEO Pharma logoLEO Pharma·N/A·NCT03788863·99,999 enrolled
Suprazygomatic Block in Cleft Palate Surgery in Children
Completed·—·Phase 2·NCT03412474·80 enrolled
Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair
Completed·LLoma Linda University·N/A·NCT01500109·45 enrolled
Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants
Completed·IInstitute of Child Health·Phase 4·NCT00386269·44 enrolled
Suprazygomatic Maxillary Nerve Block in Cleft Palate Outcomes: Can we Minimize Analgesic and Opioid Use?
Completed·AAnn & Robert H Lurie Children's Hospital of Chicago·Preclinical·NCT04909619·40 enrolled
The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair
Withdrawn·UUniversity of Florida·N/A·NCT02688634
Analgesic Contribution of the Suprazygomatic Maxillary Nerve Block for Cleft Palate Surgery in Children
Withdrawn·—·N/A·NCT04023825
Dexmedetomidine vs Placebo for Pediatric Cleft Palate Repair
Withdrawn·—·Phase 4·NCT02915042
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)